Understanding the early dynamics of the 2014 porcine epidemic diarrhea virus (PEDV) outbreak in Ontario using the incidence decay and exponential adjustment (IDEA) modelResearch Article Published on 2017-01-052022-10-28 Journal: BMC veterinary research [Category] Coronavirus, MERS, [키워드] Accuracy applied Canada Characteristics Combination Course Critical cumulative decrease Developing disease Disease dynamics disease transmission effective Epidemic epidemic diarrhea epidemiological estimate evaluated feasible Forecasting Generation time help helping highly pathogenic implementation incidence initial iterative likelihood modeling morbidity and mortality outbreak parameter parameters pathogen PEDV PIGS Porcine epidemic diarrhea virus Result Spread subset swine the epidemic Transmission understanding United State virus [DOI] 10.1186/s12917-016-0922-2 PMC 바로가기 [Article Type] Research Article
Exportations of Symptomatic Cases of MERS-CoV Infection to Countries outside the Middle EastDispatch Published on 2016-04-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, MERS, [키워드] Arabian Peninsula coronavirus country disease spread estimate expected exportations Infection likelihood MERS-CoV MERS-CoV infection Middle East Middle East respiratory syndrome Coronavirus modeling outbreak respiratory syndrome coronavirus symptomatic case Travel viruses [DOI] 10.3201/eid2204.150976 PMC 바로가기 [Article Type] Dispatch
Estimation of the Basic Reproductive Number and Mean Serial Interval of a Novel Pathogen in a Small, Well-Observed Discrete PopulationResearch Article Published on 2016-02-052022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, 신종인플루엔자, [키워드] Algorithm arising basic basic reproductive number Combination Discrete distribution Epidemic estimate estimation Extensive Final finding generate growth human pathogen incidence initial interval Intervention less likelihood novel number outbreak parameter parameters pathogen Population populations public health real time recent required susceptible the timing Transmissibility unique [DOI] 10.1371/journal.pone.0148061 PMC 바로가기 [Article Type] Research Article
Potential Broad Spectrum Inhibitors of the Coronavirus 3CL pro : A Virtual Screening and Structure-Based Drug Design StudyArticle Published on 2015-12-152022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] 3CL pro 3CLpro acute respiratory syndrome Antiviral approach can be used Cluster Compound Consensus coronavirus coronavirus cross defined disease drug drug design drug target experiments Features Glide highlight Human human coronaviruses Infection inhibitor less likelihood MERS Middle East molecular molecular docking molecular dynamics outbreak Potential provide screened Screening sequence homology significantly Spectrum Structure-based drug design subset syndrome these compound Virtual screening [DOI] 10.3390/v7122963 PMC 바로가기 [Article Type] Article
A cluster randomized controlled trial to increase the availability and acceptability of voluntary medical male circumcision in Zambia: The Spear and Shield Project잠비아에서 자발적인 의료 남성 할례의 가용성과 수용 가능성을 높이기 위한 클러스터 무작위 대조 시험: The Spear and Shield ProjectArticle Published on 2015-06-172022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] 95% CI adjusted odds ratio adverse event adverse events assigned baseline Care center Cluster community health Community health centers conditions conducted Control Controlled trial counseling death expressed female finding funding Health Health care HIV HIV infection HIV prevention Intervention likelihood male men MOST Odds ratio participant Participants Participation Patient performed post-intervention Prevalence prevention programs Primary outcome randomization Randomized controlled trial Randomly reported Result Shield significant increase Spear statistician stratified study participation supply Support tested Trial registration [DOI] 10.1016/S2352-3018(15)00042-9 PMC 바로가기 [Article Type] Article
A HECT Ubiquitin-Protein Ligase as a Novel Candidate Gene for Altered Quinine and Quinidine Responses in Plasmodium falciparum플라스모듐 팔시파룸(Plasmodium falciparum)에서 변경된 퀴닌 및 퀴니딘 반응에 대한 새로운 후보 유전자로서의 HECT 유비퀴틴-단백질 리가제Research Article Published on 2014-05-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Altered analysis antimalarial antimalarial drug Asia association candidate candidate gene changes in chromosome chromosome 13 complex conducted contribute contributing to cross cytotoxic activity defend demonstrated drug Efficacy experiment Factor Factors Genetic genetic screens genetic trait identify IMPROVE initial isolate Laboratory Ligase likelihood locus malaria malaria parasite moderate multiple allele multiple alleles mutated novel occur P. falciparum Plasmodium falciparum preservation progeny Quantitative quantitative trait locus quinidine Quinine response responsiveness segment sensitivity strain subset Surveillance susceptibility These data Treatment treatment failure ubiquitin ligase [DOI] 10.1371/journal.pgen.1004382 PMC 바로가기 [Article Type] Research Article
Yeast Based Small Molecule Screen for Inhibitors of SARS-CoVResearch Article Published on 2011-12-022022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] activities activity Alter bypasse Cell culture cells cellular connection conserved Course demonstrated deubiquitinase Diversity expressed functional growth human coronaviruses induce induction Influenza virus inhibit inhibited inhibiting the function inhibitor inhibitory compounds investigated likelihood mammalian cells mechanism modify molecule Mortality NIH outbreak Papain-like protease phenotype PLP precursor protease Protease activity Replication reservoir Respiratory Coronavirus resulting S. cerevisiae SARS-CoV Screen severe shown small molecule suppressor toxic effect virus replication yeast [DOI] 10.1371/journal.pone.0028479 PMC 바로가기 [Article Type] Research Article