Identification of Clec4b as a novel regulator of bystander activation of auto-reactive T cells and autoimmune disease자가 반응성 T 세포 및 자가면역 질환의 방관자 활성화에 대한 새로운 조절자로서의 Clec4b의 확인Research Article Published on 2020-06-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence Activation Antigen antigen-presenting cell antigen-presenting cells Arthritis Autoimmune Autoimmune disease Autoimmune diseases Autoimmunity autoreactive T cell autoreactive T cells avoidance bystander CD11b CD4 CD4+ Cell chronic inflammation classical Clinical diagnosis complex Control control mechanism Critical DCs defined dendritic cell dendritic cells dependent on disease early disease expansion expressed expression followed by Genetic identification identify immune regulation immune response immune-priming in vitro in vivo injection limit loss of function marker mechanism MHCII myeloid cells nucleotide pathogenic pathway polymorphism receptor recombinant recombinants regulate Regulatory reveal rheumatoid arthritis shown single nucleotide Single nucleotide polymorphism Strains T cell T cells turn [DOI] 10.1371/journal.pgen.1008788 PMC 바로가기 [Article Type] Research Article
Clinical and Immune Features of Hospitalized Pediatric Patients With Coronavirus Disease 2019 (COVID-19) in Wuhan, ChinaResearch Published on 2020-06-032022-10-29 Journal: JAMA Network Open [Category] COVID-19, [키워드] acute respiratory syndrome age alanine aminotransferase ALT analyzed Aspartate aminotransferase association AST B cell B cells biochemical Case series case sery caused CD4 Characteristics children CK-MB clinical Clinical characteristics Clinical management collected coronavirus coronavirus disease COVID-19 Critically ill decrease disease severity dysregulation exposure feature finding immune immune response Immunoglobulin Importance Infection Inflammatory cytokine Inflammatory response information interferon γ interquartile range involved laboratory abnormality laboratory-confirmed lactate dehydrogenase LDH liver lymphocyte Lymphocytes lymphopenia measure median Mild mild case mild cases moderate Moderate COVID-19 moderate disease myocardial injury Necrosis neutrophil Neutrophils objective occurred participant Pathogenesis pathogenesis of SARS-CoV-2 pathologic process Patient Pediatric patient Pediatric patients Pneumonia Point positive Relevance reported Result SARS-CoV-2 SARS-COV-2 infection setting severe cases single-center statistically significant difference systemic inflammation T cell T cells with COVID-19 with mild disease Wuhan Wuhan, China [DOI] 10.1001/jamanetworkopen.2020.10895 PMC 바로가기 [Article Type] Research
Decreased B Cells on Admission Associated With Prolonged Viral RNA Shedding From the Respiratory Tract in Coronavirus Disease 2019: A Case-Control StudyArticle Published on 2020-05-312023-07-01 Journal: The Journal of Infectious Diseases [Category] SARS, [키워드] B cells COVID-19 IL-10 T cells Viral RNA shedding [DOI] 10.1093/infdis/jiaa311 PMC 바로가기
Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed IndividualsArticle Published on 2020-05-202023-06-14 Journal: Cell [Category] MERS, SARS, [키워드] CD4 CD8 coronavirus COVID-19 cross-reactivity Epitopes SARS-CoV-2 T cells [DOI] 10.1016/j.cell.2020.05.015 PMC 바로가기 [Article Type] Article
Immune environment modulation in pneumonia patients caused by coronavirus: SARS-CoV, MERS-CoV and SARS-CoV-2Research Paper Published on 2020-05-152022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, MERS, SARS, [키워드] 24 hours acute respiratory distress ARDS cause caused CD3+ CD4+ CD8+ T lymphocyte changes in chemokine coding Coronavirus infections COVID-19 Critical current cytokine cytokine profile Cytokine storm death demonstrated disease dry cough elevated fatigue Fever global pandemic highlight IFN-α2 IFN-γ IL-10 IL-1α IL-1β IL-6 IL-7 immune factor indicated infection process infiltration interferon lymphocyte Lymphocytes MERS-CoV modulation monocyte NK cell Patient patients with COVID-19 Pneumonia resulting SARS-CoV SARS-CoV-2 significantly syndrome T cells the cytokine storm treated Treatment [DOI] 10.18632/aging.103101 PMC 바로가기 [Article Type] Research Paper
The challenge of COVID-19 and hematopoietic cell transplantation; EBMT recommendations for management of hematopoietic cell transplant recipients, their donors, and patients undergoing CAR T-cell therapyPerspective Published on 2020-05-132022-10-28 Journal: Bone marrow transplantation [Category] COVID-19, MERS, SARS, [키워드] age Allogeneic autologous Cancer candidate CAR Care Cell cell transplantation cellular condition COVID-19 COVID-19 pandemic Diseases Donor donors European Factor HCT Health Health care include Infectious disease management Marrow new coronavirus SARS-CoV-2 pandemic Patient patients physician recipient recipients recommendation severe disease Society Spread Stress T cells T-cell the disease therapy transplantation WHO working [DOI] 10.1038/s41409-020-0919-0 PMC 바로가기 [Article Type] Perspective
Dynamics of peripheral immune cells and their HLA‐G and receptor expressions in a patient suffering from critical COVID‐19 pneumonia to convalescenceCase Report Published on 2020-05-102022-10-31 Journal: Clinical & Translational Immunology [Category] COVID-19, [키워드] B cell CD4 CD8 Cell clinical collected convalescent stage COVID‐19 COVID‐19 Critical cytokine Cytokines Dynamics expression flow cytometry fluctuation gradually increased HLA‐G IFN‐γ IL‐4 IL‐6 Immune cell immune cells immune response Immunological response information Initially KIR2DL4 leucocyte lymphopenia medical records monocyte neutrophil count objective Patient peripheral immune cells Pneumonia public health receptor remained Result returned SARS‐CoV‐2 infection SARS‐CoV‐2 T cell T cells the disease the patient TNF‐α Viral RNA WBC were measured [DOI] 10.1002/cti2.1128 PMC 바로가기 [Article Type] Case Report
Detection of SARS-CoV-2-Specific Humoral and Cellular Immunity in COVID-19 Convalescent IndividualsShort communication Published on 2020-05-032022-10-05 Journal: Immunity [Category] SARS, 치료기술, [키워드] activity Adaptive immune response Adaptive immunity Analysis antibodies Antibody titer Blood cellular immunity Cohort collected correlation COVID-19 COVID-19 patient COVID-19 patients detection discharge discharged discharged patients effective eight Follow-up analysis humoral IgG immune responses Immunoglobulin implication individual neutralization outbreak pathogenesis of COVID-19 Patient protective immunity provide pseudotype SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus SARS-CoV-2-specific antibody SARS-CoV-2-specific T cells severe cases T cells tested Vaccine World Health Organization worldwide pandemic [DOI] 10.1016/j.immuni.2020.04.023 [Article Type] Short communication
Early Induction of Cross-Reactive CD8 + T-Cell Responses in Tonsils After Live-Attenuated Influenza Vaccination in ChildrenArticle Published on 2020-05-012023-06-14 Journal: The Journal of Infectious Diseases [Category] Fulltext, 신종인플루엔자, [키워드] children IFN-γ LAIV T cells tonsils [DOI] 10.1093/infdis/jiz583 PMC 바로가기
Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)코로나바이러스 질환 2019(COVID-19) 환자의 T 세포 감소 및 기능 소진Immunology Published on 2020-05-012022-09-06 Journal: Frontiers in Immunology [Category] Communicable Disease, COVID-19, MERS, SARS, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition antiviral immunity Care caused CD4 CD8 Concentration coronavirus coronavirus disease Coronavirus disease 2019 correlated count COVID-19 COVID-19 cases COVID-19 patient COVID-19 patients Critical cytokine cytokine strom Deterioration Exhaustion expression functional Health healthy controls high risk ICU IL-10 IL-6 Increasing intensive care unit Intervention laboratory-confirmed Laboratory-confirmed COVID-19 marker non-ICU non-ICU patients outbreak Patient patient survival PD-1 progressed reduced respiratory restored SARS- CoV-2 SARS-CoV-2 serum serum cytokine Serum IL-6 severe acute respiratory syndrome Coronavirus severe symptom significantly significantly higher stages surviving T cell symptomatic T cell T cell exhaustion T cell reduction T cells the disease TNF-α were measured [DOI] 10.3389/fimmu.2020.00827 PMC 바로가기 [Article Type] Immunology