Mammalian Hbs1L deficiency causes congenital anomalies and developmental delay associated with Pelota depletion and 80S monosome accumulation포유류 Hbs1L 결핍은 Pelota 고갈 및 80S 모노솜 축적과 관련된 선천적 기형 및 발달 지연을 유발합니다Research Article Published on 2019-02-012022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 4EBP1 accompanied accumulation addition affecting aggregation Anomaly baseline biallelic mutation biallelic mutations binding cause caused Cell cells Characteristics characterized coding region conditions control mechanisms controls Critical deficiency demonstrated Depletion developmental delay downstream Effect Efficiency element expression facial fibroblast fibroblasts functional growth Hbs1L human cell human cells humans hypotonia implicated increase in inhibition involved knockdown lack lead Loss mechanism mice monosome mouse model mRNA mRNA level mTOR mTOR expression murine Mutation ortholog pathway Patient pelo phenotype phenotypic Phosphorylation polysome proteasomal proteasome Protein protein expression Quality control reduced Regulation reported rescued restored resulting ribosomal RNA ribosome ribosomes RNA RT-PCR Sequencing Support the patient These data tissues transcript translation translational upregulation utilization western blot Western blot analyses Western blot analysis yeast [DOI] 10.1371/journal.pgen.1007917 PMC 바로가기 [Article Type] Research Article
Cyclic di-AMP regulation of osmotic homeostasis is essential in Group B Streptococcus삼투성 항상성의 순환 di-AMP 조절은 B군 연쇄상 구균에서 필수적입니다Research Article Published on 2018-04-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence accumulating accumulation assumed Bacteria Bacterial betaine bind binding cellular cellular physiology compensatory mutations conditions conserved Control cyclic dacA Deletion demonstrated dependent on enzyme etiological agent expression function functional glycine glycine betaine group growth homeostasis host cell host cells host-pathogen interactions hyperosmotic identification identify Infection involved leads Loss loss-of-function loss-of-function mutation maintain mechanism medium Meningitis monophosphate mutant Mutation Neonatal nucleotide nucleotides opportunistic pathogen osmolyte osmoregulation osmotic osmotic regulation pathogen pathway phenotype Potassium predominant promoter Protein regulate Regulation second messenger second messengers secondary messenger septicaemia Streptococcus Streptococcus agalactiae susceptibility Transcription transcriptional viability [DOI] 10.1371/journal.pgen.1007342 PMC 바로가기 [Article Type] Research Article
HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expressionHPV 통합은 높은 바이러스 종양 유전자 발현을 유도하는 바이러스 세포 슈퍼 인핸서를 생성하기 위해 세포 인핸서를 가로채고 다량체화합니다.Research Article Published on 2018-01-242022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulation amplification amplified BRD4 Cancer cancers cellular cellular DNA chromatin chromosome composed de novo dysregulated element enhancer Epigenetic example expressed expression generate genesis Genetic Genome genomic H3K27ac Host HPV human cancers human papillomavirus Infection integration intergenic region loci locus marker mechanism molecular mutations Next-generation sequencing oncogene oncogenesis papillomavirus positive promote promoted provide random regulatory region responsible sequence super-enhancer transcript Transcription tumors Type unique upstream Viral viral DNA viral genome virus [DOI] 10.1371/journal.pgen.1007179 PMC 바로가기 [Article Type] Research Article
A two-step transport pathway allows the mother cell to nurture the developing spore in Bacillus subtilis2단계 수송 경로를 통해 모세포가 Bacillus subtilis에서 발달 중인 포자를 양육할 수 있습니다.Research Article Published on 2017-09-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulate accumulation Bacillus anthracis Bacillus subtilis Bacteria Bacterial Cell Clostridium difficile complex Concentration conserved Culture culture medium dehydration desiccation dipicolinic acid displace dormancy dormant dry weight engulfment enzyme Enzymes Evidence Express Factor forespore hallmark hallmarks homolog homologs idea late stage mechanism medium membrane membranes molecular basis Morphological mother mother cell Mutagenesis non-pathogenic bacteria nucleoside pathogenic pathway predicted produced Protective Protein pyridine-2,6-dicarboxylic acid remained required residue residues small molecule spore spore core spores sporulation Support translocated Transport vegetative growth water [DOI] 10.1371/journal.pgen.1007015 PMC 바로가기 [Article Type] Research Article
Crosstalk between the tricarboxylic acid cycle and peptidoglycan synthesis in Caulobacter crescentus through the homeostatic control of α-ketoglutarateα-케토글루타레이트의 항상성 조절을 통한 Caulobacter crescentus의 트리카르복실산 회로와 펩티도글리칸 합성 간의 누화Research Article Published on 2017-08-212022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulation addition Alter Antibiotics approach approaches Bacteria bacterial cell bacterial cells biosynthetic block blocks building by-product Caulobacter crescentus caused Cell cell wall cell wall synthesis cellular cellular metabolism cellular processe cellular processes central metabolism characterized classical conserved CRISPRi Crosstalk deletion mutant Disruption drug design energy generate genetics growth highlight homeostasis homeostatic inhibit interfere Interference master regulator metabolism metabolite metabolomics Morphological morphology mutant peptidoglycan phenotype precursors property Replication required resulting reveal robust susceptibility susceptible synthesis TCA cycle the cell transcriptomics tricarboxylic acid while [DOI] 10.1371/journal.pgen.1006978 PMC 바로가기 [Article Type] Research Article
Evidence for the evolutionary steps leading to mecA -mediated β-lactam resistance in staphylococci포도상구균에서 mecA 매개 β-락탐 내성으로 이어지는 진화 단계에 대한 증거Research Article Published on 2017-04-102022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulation acquisition adaptation Amino acid Analysis antibiotic Antibiotic resistance Antibiotics Author Bacteria Bacterial Bayesian analysis binding binding domain cell wall cell wall synthesis changes in chromosome Community core genome development domain driving epidemiologically Evolution exposure to food additives gene encoding Genetic genetic background genomes highlight homologue identify involved isolates livestock mechanism mechanisms methicillin methicillin-resistant Staphylococcus aureus Mortality MRSA mutation rate Mutation rates non-binding nucleotide occur occurred oxacillin Pandemics PBP penicillin phenotype Phylogenetic analysis precursor predicted profiles promoter promoters Protein representing resistance gene resource responsible S . aureus SCC selective sequence sequence alignments sequenced genome single-nucleotide polymorphism SNP species Spread Staphylococcus Staphylococcus aureus strain Substitution substitutions susceptibility variety was performed [DOI] 10.1371/journal.pgen.1006674 PMC 바로가기 [Article Type] Research Article
Overlapping SETBP1 gain-of-function mutations in Schinzel-Giedion syndrome and hematologic malignanciesSchinzel-Giedion 증후군 및 혈액 악성 종양에서 중복 SETBP1 기능 획득 돌연변이Research Article Published on 2017-03-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulation activating affecting alteration alterations Author Cancer caused cell proliferation cellular characterized clinical information clinical phenotype Clustering Cohort collected de novo de novo mutation Degradation developmental developmental disorder developmental disorders disrupt Disruption distribution Drawing driven by driving Effect event events ExoN functional gain-of-function genetics Genotype genotype-phenotype correlation germline Hematologic malignancy hotspot implicated in silico in vitro incidence increase in increased risk individual lead leukemia magnitude malformation malignancy Mendelian disorder Mendelian disorders molecular Mutation mutations neurological occur overlap Patient phenotype prenatal development Previous studies previous study Protein protein level protein levels Regulation required residue risk SETBP1 signal significantly more somatic mutation somatic mutations stability subject Substitution substitutions Support syndrome threshold [DOI] 10.1371/journal.pgen.1006683 PMC 바로가기 [Article Type] Research Article
An Essential Nonredundant Role for Mycobacterial DnaK in Native Protein Folding천연 단백질 폴딩에서 마이코박테리아 DnaK의 필수 비중복 역할Research Article Published on 2014-07-242022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a minor absence accompanied accumulation aggregate antibiotic Bacterial pathogens bacterium Cell cell growth cells cellular chaperone chaperones characterized daughter cells Degradation denaturation Disruption domain E. coli Essential examined expand expression Factor foci genus growth heat Host Hsp70 identify include insoluble lack less life Loss membrane minor mycobacteria mycobacterial Mycobacterium Native organism paradigm Pathogens peptide peptides Prevent Protein protein folding Protein misfolding Proteins redundancy required role solubility stationary stationary phase Stress susceptibility synthases translation Trigger unique viability [DOI] 10.1371/journal.pgen.1004516 PMC 바로가기 [Article Type] Research Article
Digital Genotyping of Macrosatellites and Multicopy Genes Reveals Novel Biological Functions Associated with Copy Number Variation of Large Tandem RepeatsMacrosatellites 및 Multicopy 유전자의 디지털 유전형 분석은 대규모 직렬 반복의 복사 수 변화와 관련된 새로운 생물학적 기능을 나타냅니다.Research Article Published on 2014-06-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accompanied accumulation accumulations Analysis approach approaches association Biological Biological functions changes in copy copy number correlation Digital DNA methylation DNA methylation levels Effect Effects eukaryotic Evolution example expansion extreme FIVE focus fraction function functional Gene Expression Genes Genome genome assembly Genome-wide association study genomes genomic Genotype GWAS hallmark hallmarks human population human populations humans identify include information lead Local loci majority mechanism modulating non-human primates novel nucleotide number Organisms phenotypic diversity Population Previous studies Repeat repeated selective selective pressure sequence significantly single nucleotide single nucleotide variation SNP SNPs suppression tandem tandem repeat tandem repeats transgenic utility Variability variant variants Variation variations [DOI] 10.1371/journal.pgen.1004418 PMC 바로가기 [Article Type] Research Article
The Transcription Factor BcLTF1 Regulates Virulence and Light Responses in the Necrotrophic Plant Pathogen Botrytis cinerea전사 인자 BcLTF1은 괴사성 식물 병원체 Botrytis cinerea에서 독성과 빛 반응을 조절합니다Research Article Published on 2014-01-092022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence accumulation addition Affect alternative oxidase alternative respiration enzymes antioxidants AOX apothecia applied approach arising Aspergillus nidulan Aspergillus nidulans Author BcLTF1 bctlf1 Botrytis cinerea caused characterized circadian rhythm conditions conidia continuous light Deletion dependent on detoxification detrimental effect detrimental effects dicotyledonous plant differentiation dispersal ecological ecological niche equilibrium Evidence exogenously exposure to expression expression level expression levels expression of gene Factor fertilization filamentous fungi fruiting bodies function fungal fungal pathogen fungi fungus GATA transcription factor Gene gene encoding Genes gray mold disease gray mold diseases growth rate growth rates homoeostasis homologue Host host infection hypersensitivity illumination impair Increased increased expression induce Infection LIGHT macroconidia macromolecule macromolecules majority metabolism Microarray analyses Microarray analysis microconidia mitochondrial mitochondrial dysfunction modulated mutant mutants necrotrophic pathogen necrotrophic pathogen Botrytis cinerea Neurospora crassa NsdD Organisms Orientation over-expression overexpression oxidative stress oxygen Pathogens photomorphogenesis photoreceptor phototropism pigments plant plants predicted propagule propagules PROTECT random mutagenesis reactive oxygen species reactive oxygen specy Regulation reproductive required respiration enzymes respond response restoration ROS scavenging sclerotia Secondary metabolism sexual reproduction singlet oxygen spores Structure structures SUB-1 survival TF 1 transcription factor transcriptional level virulence [DOI] 10.1371/journal.pgen.1004040 PMC 바로가기 [Article Type] Research Article