A Computational Approach to Evaluate the Combined Effect of SARS-CoV-2 RBD Mutations and ACE2 Receptor Genetic Variants on Infectivity: The COVID-19 Host-Pathogen Nexus감염에 대한 SARS-CoV-2 RBD 돌연변이와 ACE2 수용체 유전 변이의 결합된 효과를 평가하기 위한 전산 접근 방식: COVID-19 숙주-병원체 넥서스Cellular and Infection Microbiology Published on 2021-08-092022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 변종, [키워드] ACE ACE2 ACE2 receptor ACE2 variant angiotensin converting enzyme 2 receptor approach association binding circulating Combined complex Contact COVID-19 destabilize determined by Effect evaluate free energy GISAID hydrophobic hydrophobic interaction hydrophobic interactions implication individuals infection rate mitigate molecular molecular interaction Mutation mutations nexus offer pattern PDB platform polar polymorphism Population Protein Protein binding RBD Receptor binding domain reported Repository residues retrieved SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 mutations SARS-CoV-2 RBD spike Spike protein stability the disease variant Variation variations virus virus spike protein Virus-host interaction ΔΔG [DOI] 10.3389/fcimb.2021.707194 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
New prophylaxis regimen for SARS-CoV-2 infection in health professionals with low doses of hydroxychloroquine and bromhexine: a randomised, double-blind placebo clinical trial (ELEVATE Trial)Randomized Controlled Trial Published on 2021-08-032022-10-04 Journal: BMJ Open [Category] SARS, 임상, [키워드] 1:1 ACE Administered approval approved caused cell entry cleave clinical pharmacology clinical trial clinical trials Commission COVID-19 defined double-blind early stages effective Efficacy Endpoint Ethics ethics committee expected group HCQ Health health worker healthy host cell Hydroxychloroquine Infection Infectious diseases Intervention Local low dose Luis mechanism membrane Mortality New participant Patient peer-reviewed Placebo Preventive medicine professional progression prophylactic treatment Prophylaxis protease protection protocol randomised receptor reduction in regimen risk Sample size SARS-CoV-2 SARS-COV-2 infection serine 2 shown spike glycoprotein submitted the placebo group transmembrane two group virus [DOI] 10.1136/bmjopen-2020-045190 PMC 바로가기 [Article Type] Randomized Controlled Trial
Comparison of Medication Prescribing Before and After the COVID-19 Pandemic Among Nursing Home Residents in Ontario, CanadaObservational Study Published on 2021-08-022022-10-04 Journal: JAMA Network Open [Category] MERS, SARS, 임상, [키워드] absolute difference accelerate ACE ACE inhibitors adverse effect Affect Analysis angiotensin receptor blocker Angiotensin-converting enzyme Antibiotics ARBs association average base Canada Care change changes in Cohort cohorts consequence Course COVID-19 COVID-19 pandemic Effect exposure finding function Health home Importance increases in inhibitors initial Intervention measure medication medications MONITOR Nursing objective observation observation period Older Onset outcomes pandemic parameter participant Point population-based cohort prescribing prescription medication professional proportion ranged Relevance resident Result selected setting significant increases in significant level standard error statistically significant tested Uncertainty use of antibiotics Weekly [DOI] 10.1001/jamanetworkopen.2021.18441 PMC 바로가기 [Article Type] Observational Study
Role of ACE2 in pregnancy and potential implications for COVID-19 susceptibility임신에서 ACE2의 역할과 COVID-19 감수성에 대한 잠재적 영향Review Published on 2021-08-022022-09-11 Journal: Clinical Science (London, England : 1979) [Category] MERS, SARS, 바이오마커, [키워드] ACE ACE2 ACE2 protein acute respiratory syndrome angiotensin angiotensin converting enzyme 2 Angiotensin-converting enzyme cardiovascular disease cells changes in children circulation coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 susceptibility Critical deplete disease manifestation disorder during pregnancy Effect Evidence evidence of feature Follow-up hemodynamic impair implication IMPROVE indicate Infection information Kinin knowledge main receptor management mechanism molecular mother organ physiological system physiological systems Placenta placental biology placentation pregnancies Pregnancy Protective RAS renin–angiotensin system Replication respiratory risk role SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome Significant Stratification Transmission vertical transmission Viral viral entry viral infection with COVID-19 [DOI] 10.1042/CS20210284 PMC 바로가기 [Article Type] Review
Covid-19 pandemic: Perspectives on management코로나19 팬데믹: 경영에 대한 관점Review Published on 2021-08-012022-09-11 Journal: Journal of reproductive immunology [Category] SARS, 임상, 치료제, [키워드] ACE ACE inhibitors angiotensin Angiotensin receptor blockers assisted ventilation benefit Care clinical trials country COVAX COVID-19 COVID-19 vaccines decrease develop Dexamethasone dissemination distribution drug effective effective drug effective drugs effective therapy Efficacy Evidence evidence of form hypoxia ICU care identify in vitro activity Infection low dose dexamethasone management medical treatment Mild mRNA-based vaccine pandemic Patient Pneumonia preliminary evidence preventing infection progression provided randomized trial randomized trials receptor refrigeration Regulatory Remdesivir required retroviral SARS-CoV-2 severe disease shown supportive care the WHO Treatment vaccination Vaccine Vaccines virus [DOI] 10.1016/j.jri.2021.103344 PMC 바로가기 [Article Type] Review
Blue Biotechnology: Computational Screening of Sarcophyton Cembranoid Diterpenes for SARS-CoV-2 Main Protease InhibitionBlue Biotechnology: SARS-CoV-2 주요 프로테아제 억제를 위한 Sarcophyton Cembranoid Diterpenes의 컴퓨터 스크리닝Comparative Study Published on 2021-07-132022-09-10 Journal: Marine Drugs [Category] SARS, 비임상, [키워드] ACE Achille affected Analysis Antiviral antiviral agent antiviral drug antiviral drugs assembly binding binding affinities binding affinity binding energy Bioavailability biochemical blue breath cembranoid diterpenes metabolites characterized coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 treatment darunavir database died diterpene drug Effects enrichment analysis ESR1 established therapy examined FIVE genus genus Sarcophyton HIV protease inhibitor in silico in vitro in vivo indicate inhibit inhibition inhibitor inhibitors M pro manifested MAPK MAPK14 MD simulations metabolite molecular molecular docking molecular dynamics Molecular mechanics over pandemic pathway Pathway enrichment analysis polyprotein protease protein-protein interaction Reactome robust SARS-CoV-2 SARS-CoV-2 main protease screened Screening Signaling STRING database surface area Treatment Viral viral replication [DOI] 10.3390/md19070391 PMC 바로가기 [Article Type] Comparative Study
Andrographolide binds to spike glycoprotein and RNA-dependent RNA polymerase (NSP12) of SARS-CoV-2 by in silico approach: a probable molecule in the development of anti-coronaviral drugShort Communications Published on 2021-07-132022-10-30 Journal: Journal of Genetic Engineering & Biotechnology [Category] COVID-19, [키워드] ACE ACE 2 receptor andrographolide angiotensin-converting enzyme 2 Antiviral bind binding candidate Cell Coronaviridae family database docking result domain drugs exhibit Genome homology host cell host cells identify in silico in silico Approach infect Infection inhibitor inhibitory Interaction Nsp12 plant protein sequence Proteins RBD RNA RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 searched spike glycoprotein Spread tested the SARS-CoV-2 virus unique virus [DOI] 10.1186/s43141-021-00201-7 PMC 바로가기 [Article Type] Short Communications
Impact of I/D polymorphism of angiotensin-converting enzyme 1 (ACE1) gene on the severity of COVID-19 patients코로나19 환자의 중증도에 대한 ACE1(지오텐신 전환 효소 1) 유전자의 I/D 다형성의 영향Article Published on 2021-07-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] ACE ACE I/D polymorphism ACE1 ACE2 ACE2 receptor acute respiratory disease acute respiratory syndrome ADRS allele angiotensin angiotensin I Angiotensin II Angiotensin-converting enzyme association Asymptomatic binding cause Chain Reaction China Clinical outcome Corona virus coronavirus COVID-19 COVID-19 patient detect diabete diabetes disease etiology facilitate followed by Frequency Genotype genotyped host cell hypertension I/D I/D polymorphism Imbalance Impact incidence Interaction Lung injury marker Older age Pathogenesis Patient polymerase chain polymerase chain reaction Predictive researcher respiratory risk RT-PCR SARS-CoV-2 SARS-CoV2 Severe acute respiratory syndrome Severe acute respiratory syndrome corona virus-2 severe COVID-19 severe lung injury severity severity of COVID-19 significantly significantly higher SPSS statistical analysis susceptibility syndrome These data Version [DOI] 10.1016/j.meegid.2021.104801 PMC 바로가기 [Article Type] Article
Shining More Light on RAS Inhibition during the COVID-19 PandemicCOVID-19 전염병 동안 RAS 억제에 대해 더 많은 빛을 비추다Editorial Published on 2021-07-012022-09-11 Journal: Clinical journal of the American Society of Nephro [Category] SARS, 임상, [키워드] Abstract ACE ACE inhibitors angiotensin COVID-19 dialysis inhibition kidney Kidney transplantation LIGHT Mortality RAS Virology [DOI] 10.2215/CJN.06000521 PMC 바로가기 [Article Type] Editorial
A pilot study to assess the circulating renin-angiotensin system in COVID-19 acute respiratory failureClinical Trial Published on 2021-07-012022-10-05 Journal: American journal of physiology. Lung cellular and [Category] SARS, 임상, [키워드] ACE ACE2 acute respiratory distress acute respiratory distress syndrome Alternative pathway ANG angiotensin angiotensin-converting enzyme 2 Anti-inflammatory cellular entry circulating clinical trial clinical trials Cohort cohorts component Concentration conducted Control controls COVID-19 Critical Critical care Degradation demonstrated Enrollment Ex vivo Hypothesis hypoxic respiratory failure ICU increased mortality Interaction laboratory assays Mild moderate Multiple no significant difference outcomes pathway Patient patients with moderate peptidase peptide physiological pilot study proinflammatory prolonged intensive care RAS reduction in renin-angiotensin system Respiratory failure SARS-CoV-2 severe COVID-19 severe COVID-19 cohort severity Signaling the SARS-CoV-2 virus were measured [DOI] 10.1152/ajplung.00129.2021 PMC 바로가기 [Article Type] Clinical Trial