Adaptive immune response – Page 9 – Communicable Diseases Research

Robust Virus-Specific Adaptive Immunity in COVID-19 Patients with SARS-CoV-2 Δ382 Variant Infection

SARS-CoV-2 Δ382 변이 감염이 있는 COVID-19 환자의 강력한 바이러스 특이적 적응 면역

Original Article

Published on 2021-10-302022-09-10
Journal: Journal of Clinical Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 치료기술, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response Antibody Response CD4⁺ T cell response CD8⁺ T cell response coronavirus correlated COVID-19 COVID-19 patients Cytokines disease phenotype dominant enrichment eukaryotic eukaryotic initiation factor 2 evidenced host immunity Host–pathogen interaction identify immune immune signature Immunity initiation factor less molecular Mutation nucleotide deletion ORF7b ORF8 pandemic progresse Patient pro-inflammatory cytokines profile provide Region respiratory RNA-sequencing robust SARS-CoV-2 SARS-CoV-2 infected patient SARS-COV-2 infection SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus Signaling spike mutations supplementary material systemic inflammation systemic level T cell therapeutic target Transcriptome upregulated variants of concern VOCs was performed whole blood transcriptomic wildtype Δ382
[DOI] 10.1007/s10875-021-01142-z PMC 바로가기 [Article Type] Original Article

Autoinflammatory Diseases and Cytokine Storms—Imbalances of Innate and Adaptative Immunity

Review

Published on 2021-10-182022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS,

Prime-Boost Vaccination With Covaxin/BBV152 Induces Heightened Systemic Cytokine and Chemokine Responses

Immunology

Published on 2021-10-152022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, SARS,

Basophils and Mast Cells in COVID-19 Pathogenesis

Review

Published on 2021-10-142022-10-31
Journal: Cells [Category] COVID-19, MERS, SARS,

Association of HLA class I and II genes with Middle East respiratory syndrome coronavirus infection in Koreans

Short Report

Published on 2021-10-122022-10-30
Journal: Immunity, Inflammation and Disease [Category] COVID-19,

Obesity Correlates With Pronounced Aberrant Innate Immune Responses in Hospitalized Aged COVID-19 Patients

비만은 입원한 노인 COVID-19 환자의 비정상적인 선천성 면역 반응과 관련이 있습니다

Comparative Study

Published on 2021-10-112022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response Admission Admissions advanced age age aging Antibody titers BMI caused changes in Chronic low-grade inflammation circulating Concentration coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 cytokine cytokine response Cytokines death defined dysregulated elevated Frequency hospitalizations hospitalized COVID-19 patient hospitalized COVID-19 patients host response IgG antibody IgG antibody titers immune Immune cell immune cells immune responses individual Infection Inflammatory cytokine inflammatory cytokine production Innate Innate immunity innate response intensive care intensive care unit mediators mitogen monocyte Monocytes obesity occur patients Prevalence respiratory response responsible risk risk factor Risk factors SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe coronavirus disease severe disease significant negative correlation subset These data
[DOI] 10.3389/fimmu.2021.760288 PMC 바로가기 [Article Type] Comparative Study

Impaired function and delayed regeneration of dendritic cells in COVID-19

코로나19에서 손상된 수지상 세포의 기능 장애 및 재생 지연

Clinical Trial

Published on 2021-10-062022-09-10
Journal: PLoS Pathogens [Category] MERS, SARS, 바이오마커, 임상,

[키워드] accompanied activated acute illness acute phase adaptive Adaptive immune response adaptive immune responses alteration analyzed antibody antibody-secreting cells antiviral immunity Blood CD14 CD14+ cell CD14+ cells CD163 CD4 CD86 Cell cells circulating classical monocyte classical monocytes Clinical management consequence contribute correlated COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity DCs dendritic cell dendritic cells Depletion disease disease severity downregulation dysregulated dysregulated innate immune response expansion follicular Frequency functional healthy controls helper cells HLADR hospitalized COVID-19 patient Host immune response identify immune responses immunopathology Impaired impairment Increased Inflammatory response Inflammatory responses inhibitory innate immune response long-lasting manifestation Mild modulation monocyte monocyte subsets Monocytes naïve Patient PD-L1 persistent recognize reduced reduction regeneration SARS-COV-2 infection Secondary infection secondary infections severe disease stimulate subpopulation subset susceptibility systemic inflammation T cell T cells T follicular helper cells the disease therapy these cell These cells Trigger upregulation Viral viral infection viral infections
[DOI] 10.1371/journal.ppat.1009742 PMC 바로가기 [Article Type] Clinical Trial

Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV

Article

Published on 2021-10-052022-10-04
Journal: Nature Communications [Category] MERS, SARS, 치료기술,

Sterilizing Immunity against COVID-19: Developing Helper T cells I and II activating vaccines is imperative

Review

Published on 2021-10-022023-06-15
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] MERS, SARS,

[키워드] Adaptive immune response ADV, adenovirus Antigen APC, antigen-presenting cells COVID-19 COVID-19, Coronavirus disease 2019 CXCL10, Chemokine (C-X-C motif) ligand 10 DC’s, dendritic cells IFN, interferon IgA, immunoglobin A IgG, immunoglobin G IgM, Immunoglobin M ILC’s, innate lymphoid cells ISGs, IFN-controlled genes IVV, inactivated viral vaccine LNP, Lipid Nanoparticles NA, nucleic acid NF- κB, nuclear factor κapa B PAMPs, pathogen-associated molecular patterns PRR’s, pattern recognition receptors PSO, particle swamp optimization RBD, receptor-binding domain reverse vaccinology SARS-CoV-2 SARS-COV-2, severe acute respiratory syndrome coronavirus-2 sterilizing immunity Th1, T helper 1 Th2, T helper 2 TLR, toll-like receptors URT, upper respiratory tract WHO, World Health Organization
[DOI] 10.1016/j.biopha.2021.112282 PMC 바로가기 [Article Type] Review

Meta-analysis of single-cell RNA-seq data reveals phenotypic switching of immune cells in severe COVID-19 patients

Research article

Published on 2021-10-012022-10-05
Journal: Computers in biology and medicine [Category] SARS, 바이오마커,

[키워드] acute respiratory syndrome Adaptive immune response Analysis B cell can be used CD14+ CD16+ monocyte CD4+ CD8+ T cell cell type cellular coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients disease disease severity dysregulated effective Immune cell Immune cell landscape indicate Infection innate immune response lung lung tissue M2 macrophage Macrophage management Meta-analysis moderate pandemic patients performed Peripheral blood phenotypic Phenotypic switching prognostic biomarker reached reveal RNA-Seq SARS-CoV-2 severe COVID-19 patient severe COVID-19 patients severe disease Severe patient severity Single-cell RNA sequencing single-cell RNA-seq switching therapeutic tissue Transcriptome
[DOI] 10.1016/j.compbiomed.2021.104792 [Article Type] Research article