NVX-CoV2373 vaccination induces functional SARS-CoV-2-specific CD4+ and CD8+ T cell responsesArticle Published on 2022-10-032022-11-15 Journal: The Journal of Clinical Investigation [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] Adaptive immunity CD4+ CD4+ T cell CD4+ T cells CD8+ T cell Cell Cellular immune response characteristic characterization circulating correlated COVID-19 demonstrated detectable dose Efficacy follicular full-length SARS-CoV-2 functional humoral immune responses IFN-γ immune immunization immunology individual induce magnitude Matrix-M NVX-CoV2373 Protective Protein response responses robust SARS-CoV-2-neutralizing antibody spike trimer subset T cells Th1 cell trials vaccinated individual vaccination Vaccine [DOI] 10.1172/JCI160898 PMC 바로가기
COVID-19 Alpha Variant (B.1.1.7): Humoral, memory B and T cells in COVID-19 pediatric convalescentsArticle Published on 2022-10-012023-07-10 Journal: Pediatric allergy and immunology : official public [Category] COVID19(2023년), [키워드] Adaptive immunity Convalescents COVID-19 Memory B-cells Memory T-cells pediatric SARS-CoV-2 [DOI] 10.1111/pai.13863 PMC 바로가기
Assessing and restoring adaptive immunity to HSV, VZV, and HHV-6 in solid organ and hematopoietic cell transplant recipientsHSV, VZV, 및 HHV-6에 대한 적응 면역 평가 및 회복: 고형 장기 및 조혈모세포 이식 수혜자Review Published on 2022-10-012023-05-31 Journal: Clinical microbiology and infection : the official [Category] 대상포진, 두창, 수두, 홍역, [키워드] Adaptive immunity Cell-mediated immunity Hematopoietic cell transplant herpes simplex virus human herpesvirus 6 Humoralimmunity Immunocompromisedhosts solid organ transplant Varicellazoster virus virus-specific T cells [DOI] 10.1016/j.cmi.2022.02.001 [Article Type] Review
Prospects of animal models and their application in studies on adaptive immunity to SARS-CoV-2Article Published on 2022-09-162022-11-15 Journal: Frontiers in Immunology [Category] SARS, 치료제, [키워드] adaptive Adaptive immune response Adaptive immunity addition animal model anti-SARS-CoV-2 Antiviral Clinical studies clinical symptom COVID-19 cross-immune response drugs humans immune immune memory immune response Immunity in-depth analysis Infection limitation mechanism mechanisms persistence PROTECT Protective provide Research SARS-CoV-2 the SARS-CoV-2 thresholds tissue-resident immune response. Vaccine [DOI] 10.3389/fimmu.2022.993754 PMC 바로가기
Humoral and adaptive immune responses to the SARS-CoV-2 vaccineArticle Published on 2022-09-012022-11-15 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Activation Adaptive immune response Adaptive immunity adverse outcome B.1.1.7 B.1.617.2 Blood booster booster dose CD8+ Delta dose hallmark healthy volunteer high affinity humoral humoral immune response Humoral response IFN-γ immune response Infection memory mRNA vaccine neutralizing antibody nine omicron phenotype protective antibody response SARS-CoV-2 SARS-CoV-2 specific antibody SARS-CoV-2 spike antigen SARS-CoV-2 vaccines second vaccination sera Serum level subset T cell the SARS-CoV-2 vaccination Vaccine Wuhan [DOI] 10.1016/j.ijid.2022.06.020 PMC 바로가기
Short and long-term immune changes in different severity groups of COVID-19 diseaseMulticenter Study Published on 2022-09-012023-07-10 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), [키워드] Adaptive immunity Cellular immune response COVID-19 immunology T cells [DOI] 10.1016/j.ijid.2022.07.026 PMC 바로가기 [Article Type] Multicenter Study
Considering epitopes conservity in targeting SARS-CoV-2 mutations in variants: a novel immunoinformatics approach to vaccine design변이체에서 SARS-CoV-2 돌연변이 표적화에서 에피토프 보존성 고려: 백신 설계에 대한 새로운 면역정보학 접근Article Published on 2022-08-182022-09-11 Journal: Scientific Reports [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adaptive Adaptive immunity antibody antigenicity approach Avian flu calculated collected conserved Coronavirus-2 database Developing Efficacy epitope Epitopes event flu ideal identify IEDB immune Immune Epitope Database Immunity immunodominant immunogenicity immunoinformatics mutated Mutation mutations neutralization pathogenicity platform predicted preference provide reduce Region SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 mutation selected Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Shannon entropy similarity solution technique Vaccine design Vaccines variant variants virulence virus viruses [DOI] 10.1038/s41598-022-18152-5 PMC 바로가기 [Article Type] Article
Strong T-cell activation in response to COVID-19 vaccination in multiple sclerosis patients receiving B-cell depleting therapiesB 세포 고갈 요법을받는 다발성 경화증 환자에서 COVID-19 예방 접종에 대한 강력한 T 세포 활성화Article Published on 2022-08-052022-09-11 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Adaptive immune response Adaptive immunity analyzed anti-CD20 anti-CD20 therapy antibodies antibody production B-cell binding blocking activity BNT162b2 Cellular immune response cellular response Cohort competent Complication condition controls coronavirus COVID-19 COVID-19 vaccination depleting disease driven by form forms hACE2 healthy control humoral Humoral and cellular responses IFNγ IgG antibodies IgG antibody IL-2 immunocompromised individuals Immunotherapy implication individual individuals Infection investigation mRNA mRNA-1273 mRNA-based mRNA-based vaccine multiple sclerosis no difference Ocrelizumab Patient patients proliferation RBD receiving Receptor binding domain recognizing reduced regimen relapsing respiratory rituximab SARS-CoV-2 Seroconversion seroconversion rate severe acute respiratory syndrome Coronavirus significantly significantly higher Spike protein Strong strong T-cell susceptible T-cell T-cell activation T-cell Response therapy vaccination Vaccine design virus infection [DOI] 10.3389/fimmu.2022.926318 PMC 바로가기 [Article Type] Article
Toll-like receptor-mediated innate immunity orchestrates adaptive immune responses in HBV infectionReview Published on 2022-07-292023-06-12 Journal: Frontiers in Immunology [Category] B형 간염, Fulltext, [키워드] Adaptive immunity Hepatitis B virus Innate immunity T cell response Toll-like receptor [DOI] 10.3389/fimmu.2022.965018 PMC 바로가기 [Article Type] Review
Early human B cell signatures of the primary antibody response to mRNA vaccinationmRNA 백신 접종에 대한 1차 항체 반응의 초기 인간 B 세포 서명Article Published on 2022-07-122022-09-12 Journal: Proceedings of the National Academy of Sciences of [Category] Coronavirus, COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome adaptive Adaptive immunity Adults antibodies antibody Antibody Response Antibody titers approach B cell B cells burst Cell cellular cellular response Cohort coronavirus correlated correlation defined determinant dissect dose effective first dose Frequency IgA IgG antibody Immunity immunoglobulin A individuals less magnitude MBC memory B messenger mRNA mRNA vaccination mRNA vaccines mRNA-1273 vaccine mRNA-based phenotype plasmablast Population postvaccination primary antibody protective immunity remained response RNA robust SARS-CoV-2 second dose subsequent sustained vaccination Vaccine while [DOI] 10.1073/pnas.2204607119 PMC 바로가기 [Article Type] Article