Adult patients – Page 9 – Communicable Diseases Research

Urine biomarkers for the prediction of mortality in COVID-19 hospitalized patients

COVID-19 입원 환자의 사망률 예측을 위한 소변 바이오마커

Article

Published on 2021-05-272022-09-10
Journal: Scientific Reports [Category] 바이오마커, 진단,

Reconvalescent plasma/camostat mesylate in early SARS-CoV-2 Q-PCR positive high-risk individuals (RES-Q-HR): a structured summary of a study protocol for a randomized controlled trial

초기 SARS-CoV-2 Q-PCR 양성 고위험 개인(RES-Q-HR)의 회복기 혈장/카모스타트 메실레이트: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약

Letter

Published on 2021-05-172022-08-31
Journal: Trials [Category] SARS, 임상, 치료기술, 치료제,

[키워드] accommodation acts Administered administration Adult patients Adverse adverse events alcohol Alcohol Abuse ALT anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody anticancer Antiviral antiviral therapy appearance approved AST blinded Blinding BMI body weight Bone marrow Breastfeeding CAD camostat Camostat mesylate Capsule Care Caregivers Cell Child chronic Chronic kidney disease chronic obstructive pulmonary disease chronic obstructive pulmonary disease (COPD) cirrhosis CKD clinical clinical condition Compliance Concomitant concurrent conducted control group Controlled trial convalescent plasma COPD Coronary artery Coronary artery disease cough COVID-19 COVID-19 pneumonia criteria cumulative defined diabetes Diabetes Mellitus diagnosed diagnosis of SARS-CoV-2 diarrhea disease Disease progression disease stage disorder dissemination double-blind Duration early disease Early phase of SARS-CoV-2 infection Efficacy element enrolled Enrollment enrolment EudraCT evaluate evening event evidence of Exanthema excluded exclusion criteria fatigue Fever fibrosis Germany GFR half-live headache high risk higher risk Hospitalization Hospitalized host cell hypersensitivity IgA deficiency immunization Inclusion inclusion criteria increased risk independent individual Infection infection with SARS-CoV-2 Influenza influenza A Informed consent inhibitor institution intervention arm intervention arms Kidney disease less Life expectancy likelihood Liver cirrhosis Local local Ethics Committee Mask mesylate moderate mother multicenter nasal nasal cannula Neutralizing number objective Obstructive obstructive pulmonary disease Older Ordinal Scale organ outcome outcomes oxygen oxygen demand Pancreatitis parallel group participant Participants passive immunization Patient patients hospitalized PCR Placebo plasma Plasma transfusion Pneumonia positive pregnant women Presence Prevent prevent disease progression primary endpoint progression protocol pulmonary disease pulmonary fibrosis Q-PCR randomization Randomized Randomized controlled trial receive recruitment reduce Regulatory reported risk factor safety monitoring committee Sample size SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 PCR screening visit Serine serine protease TMPRSS2 Serious Adverse Event Serious Adverse Events severe COVID-19 Shortness of breath SOC sore throat Stage Standard Standard of care stratified Stress Study protocol supplementary material Symptom symptom duration Symptoms tertiary care center tested the cell titers TMPRSS2 transfusion reaction Treatment treatment arm Trial Trial registration Tumor typical symptom typical symptoms ULN virus website WHO with COVID-19 women working hypothesis written Informed Consent
[DOI] 10.1186/s13063-021-05181-0 PMC 바로가기 [Article Type] Letter

Cytokine Profiles Before and After Immune Modulation in Hospitalized Patients with COVID-19

COVID-19로 입원한 환자의 면역 조절 전후 사이토카인 프로필

Article

Published on 2021-05-012022-09-11
Journal: Journal of Clinical Immunology [Category] SARS, 바이오마커, 진단,

[키워드] administration Admission Adult patients Algorithm association Care cluster analysis combination therapy COVID-19 Critical Critical disease CRP level CRP levels cytokine cytokine panel cytokine profile cytokine release Cytokine release syndrome Cytokines D-dimer disease severity dysregulation elevated Elevation elevations glucocorticoid Glucocorticoids HFNC Hospital stay hospitalized patient hospitalized patients Hyperinflammatory IFN-γ IL-10 IL-6 IL-6 inhibition IL-6 level immune immune dysregulation incidence increase in interleukin interleukin-10 interleukin-2 receptor (soluble) large cohort maintain marker moderate modulate modulating Mortality nippv oxygen Oxygen requirement pathway Patient performed Potential biomarker potential biomarkers profile receive receiving receptor response to treatment retrospective SARS-CoV-2 SARS-COV-2 infection severity significantly increased SpO2 Therapies therapy Tocilizumab treated Treatment with COVID-19
[DOI] 10.1007/s10875-020-00949-6 PMC 바로가기 [Article Type] Article

Machine Learning as a Precision-Medicine Approach to Prescribing COVID-19 Pharmacotherapy with Remdesivir or Corticosteroids

렘데시비르 또는 코르티코스테로이드를 사용한 COVID-19 약물 요법 처방에 대한 정밀 의학 접근 방식으로서의 기계 학습

Article

Published on 2021-05-012022-09-11
Journal: Clinical therapeutics [Category] 신약개발, 치료제,

[키워드] adjust Adult patients adverse effects age Algorithm Algorithms benefit clinical guideline coronavirus disease coronavirus disease-2019 Corticosteroid Corticosteroids COVID-19 COVID-19 crisis Electronic health record Electronic health records evaluated Gray hazard ratio hazard ratios help hospitalizations hospitalized patient hospitalized patients hospitals identify IMPROVE increase in increased survival inverse knowledge machine machine learning machine-learning men Model outcome oxygen Patient patients pharmacotherapy Population prescribing recent Remdesivir resource resources SARS-CoV-2 significantly subpopulation subset supplemental oxygen supported survival survival time tested treated Treatment treatment of COVID-19 use of corticosteroid were used with COVID-19
[DOI] 10.1016/j.clinthera.2021.03.016 PMC 바로가기 [Article Type] Article

Topical lignocaine anaesthesia for oropharyngeal sampling for COVID-19

COVID-19에 대한 구인두 샘플링을 위한 국소 리그노카인 마취

Article

Published on 2021-05-012022-09-11
Journal: European archives of oto-rhino-laryngology : offic [Category] SARS, 치료기술,

Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

COVID-19로 병원에 입원한 환자의 토실리주맙(RECOVERY): 무작위, 통제, 공개 라벨, 플랫폼 시험

Clinical Trial

Published on 2021-05-012022-08-13
Journal: Lancet (London, England) [Category] Fulltext, SARS, 임상, 진단,

[키워드] (Medical Research Council 1:1 28-day mortality 95% CI Adult patients baseline benefit C-reactive protein clinical outcomes composite endpoint Corticosteroids COVID-19 therapy death died discharged dose eligible enrolled evaluate the effect Evidence evidence of finding funding hospital hospitalised hospitalised COVID-19 patient hospitalised COVID-19 patients hypoxia Innovation intention-to-treat population intravenously Invasive mechanical ventilation ISRCTN less Medical Research Council not improved Open-label oxygen oxygen saturation Oxygen therapy Patient Platform trial Primary outcome random assignment randomised Randomised Evaluation rate ratio receiving RECOVERY trial Registered respiratory Respiratory Support risk risk ratio second dose Standard of care subgroups of patients survival systemic corticosteroids systemic inflammation the patient Tocilizumab Treatment Trial trial participant usual care weight with COVID-19
[DOI] 10.1016/S0140-6736(21)00676-0 PMC 바로가기 [Article Type] Clinical Trial

Therapeutic respiratory and functional rehabilitation protocol for intensive care unit patients affected by COVID-19: a structured summary of a study protocol for a randomised controlled trial

COVID-19의 영향을 받는 중환자실 환자를 위한 치료 호흡 및 기능 재활 프로토콜: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약

Letter

Published on 2021-04-122022-09-10
Journal: Trials [Category] MERS, 임상,

[키워드] 1:1 6-minute walk test activities activity Admission Adult patients affected age Agitation approved assessment balanced randomization blinded Blinding block blocks Borg both groups Care clinical status clinical trial Coma Comorbidities Comorbidity comparator conducted confidentiality cooperation COVID-19 criteria Critical Critical illness daily living Data collection defined discharge dissemination distribution of patient double-blind Douro Dyspnea Effect element eligible Endpoint evaluate evaluated evaluator exertion expected Follow-up for inclusion form functional functional capacity functional rehabilitation Glasgow coma scale group Handgrip strength test Health Health Service Health services Hospital stay Hospitalization Hospitalized hospitalized COVID-19 patients ICU incidence include independent intensive care intensive care unit Intervention intervention group life mechanical ventilation Medical Research Council Medicine Mobility Monday need for oxygen number Nurse nursing care objective occupational therapy occur outcome outcome measure outcomes oxygen Oxygen therapy participant Participants Patient per day Perceived physical Physical assessment physical rehabilitation Physiotherapist Physiotherapy Portugal positioning post-intensive care syndrome Potential Potential participants primary outcome measure progression protocol Quality of life question randomisation randomised randomised controlled trial randomization sequence Randomized Randomized controlled trial readmission reassurance receive recommendation recorded recruited referred to Registered registry rehabilitation rehabilitation exercises rehabilitation medicine respiratory respiratory insufficiency respiratory rehabilitation Respiratory system responsible Sample size Saturday scale Secondary objectives sequence Sex Society stability standard care Standard of care status strength test study group Study protocol subject suctioning supplementary material survey survival Test the patient therapy Tolerance treated Treatment Trial registration two groups verbal website
[DOI] 10.1186/s13063-021-05210-y PMC 바로가기 [Article Type] Letter

Providing safe care for patients in the coronavirus disease 2019 (COVID-19) era: A case series evaluating risk for hospital-associated COVID-19

코로나바이러스감염증-19(COVID-19) 시대의 환자에게 안전한 진료 제공: 병원 관련 COVID-19의 위험을 평가하는 사례 시리즈

Original Article

Published on 2021-04-052022-09-10
Journal: Infection Control and Hospital Epidemiology [Category] MERS, SARS, 치료기술,

[키워드] 95% CI 95% confidence interval Admission Admissions Adult patients Adults asked Care Case series case sery Chain Reaction coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 case defined discharge dismissal eligible evaluated hospital Hospital admission Hospital stay Hospitalization hygiene IgG likelihood pandemic Patient patients patients hospitalized PCR PCR positive PCR test PCR testing physical distancing polymerase chain polymerase chain reaction positive SARS-CoV-2 PCR Primary outcome Providing repeated respiratory Respiratory Coronavirus risk Safe SARS-CoV-2 screened Seroconversion seroconverted serologic testing serology serology testing seronegative study period tested undergo United State United States virus
[DOI] 10.1017/ice.2021.38 PMC 바로가기 [Article Type] Original Article

Early Enteral Nutrition in Mechanically Ventilated Patients With COVID-19 Infection

COVID-19 감염이 있는 기계 환기 환자의 조기 경장 영양

Observational Study

Published on 2021-04-012022-09-11
Journal: Nutrition in clinical practice : official publicat [Category] SARS, 임상, 치료기술,

[키워드] 24 hour 24 hours Adult patients Adults Analysis baseline calorie calories calory collected conducted Confirmed COVID-19 infection coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection Critical Critical care Critically ill demographics Enteral enteral nutrition Final final analysis Future greater Infection Initiation Length of stay mechanical ventilation mechanically ventilated no difference no differences nutrition Nutrition therapy observational study Other outcomes outcome Patient patient groups patients patients with COVID-19 Primary outcome Propensity score propensity score analysis propensity score matching Protein receiving remained Research retrospective SARS-CoV-2 severe coronavirus disease significant difference significantly therapy with COVID-19
[DOI] 10.1002/ncp.10629 PMC 바로가기 [Article Type] Observational Study

RAMIC: Design of a randomized, double-blind, placebo-controlled trial to evaluate the efficacy of ramipril in patients with COVID-19

RAMIC: COVID-19 환자에서 라미프릴의 효능을 평가하기 위한 무작위, 이중 맹검, 위약 대조 시험 설계

Article

Published on 2021-04-012022-09-11
Journal: Contemporary clinical trials [Category] MERS, SARS, 바이오마커, 임상,

[키워드] ACE Adult patients angiotensin Complication composite endpoint coronavirus disease Coronavirus disease 2019 COVID-19 death decrease diastolic double-blind Efficacy emergency department Endpoint evaluate exclusion criteria filtration rate glomerular filtration rate hospital ICU admission include Informed consent inhibitor Invasive mechanical ventilation Mechanical mechanical ventilation mechanical ventilator mitigate Mortality multicenter Novel coronavirus novel coronavirus disease occur patients with COVID-19 Personal protective equipment Placebo placebo-controlled trial PPE primary composite endpoint ramipril Randomized receive reduced risk risk risk of infection risk of transmission SARS-CoV-2 transmission SARS-CoV2 shown study population study visit Systolic blood pressure Treatment Virtual visit.
[DOI] 10.1016/j.cct.2021.106330 PMC 바로가기 [Article Type] Article