Moxidectin and Ivermectin Inhibit SARS-CoV-2 Replication in Vero E6 Cells but Not in Human Primary Bronchial Epithelial Cells목시덱틴과 이버멕틴은 Vero E6 세포에서 SARS-CoV-2 복제를 억제하지만 인간의 1차 기관지 상피 세포에서는 억제하지 않습니다Article Published on 2022-01-182022-09-11 Journal: Antimicrobial Agents and Chemotherapy [Category] SARS, 치료제, [키워드] ALI alleviate anti-parasitic Anti-SARS-CoV-2 Activity Antiviral antiviral activity Antiviral effect antiviral therapies bronchial caution Cell cell entry Concentration COVID-19 disease COVID-19 patient COVID-19 patients drug epithelial cells Evidence exhibited experiment following head Head-to-head comparison Health Organization High-dose Human humans in vitro in vitro model in vitro result in vivo Infection inhibit SARS-CoV-2 Interpretation Ivermectin limit Moxidectin moxidectin. performed regimen respiratory epithelial cells SARS-CoV-2 SARS-COV-2 infection severe COVID-19 disease shown switching therapy these compound these compounds treat Treatment triggered unlikely Vero Cell Vero cells Vero E6 VERO E6 cells virus World Health Organization [DOI] 10.1128/AAC.01543-21 PMC 바로가기 [Article Type] Article
Using a Deep Learning Model to Explore the Impact of Clinical Data on COVID-19 Diagnosis Using Chest X-rayArticle Published on 2022-01-162022-10-29 Journal: Sensors (Basel, Switzerland) [Category] COVID-19, SARS, [키워드] Accuracy Affect alleviate automated can be used carried Chest X-ray (CXR) Chest X-ray image clinical Clinical data clinical feature collected coronavirus COVID-19 COVID-19 diagnosis CXR Dammam deep deep learning Deep learning (DL) Diagnosis diagnosis of COVID-19 diagnostic Disease diagnosis disrupting Effect experiment f-score feature help Impact IMPROVE King learning Model pandemic Patient patient data Pneumonia Precision recall risk shown Spread the patient university used data was performed was used X-ray [DOI] 10.3390/s22020669 PMC 바로가기 [Article Type] Article
COVID-19 Knowledge/Practices, Mental Status, and Return-To-Work Concerns Among Healthcare Workers in Huangzhou District, Huanggang City, ChinaPublic Health Published on 2022-01-142022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] Adverse reaction alleviate Analysis Anxiety anxiety symptom anxiety symptoms asymptomatic infections China Chinese city Clinical efficacy concern concerning country COVID-19 cross-sectional District female form Good Granule HCW HCWs healthcare worker high risk hospital hospitals indicated investigated knowledge male Mild moderate participant preference Prevent preventative measures promotion protective factor psychological Impact Psychological state psychological support Public Hospital Quantitative recruit reduce Region reported required response Return to work risk factor risk of infection SAS Self-Rating Anxiety Scale significantly higher status TCM throat swab Traditional Chinese medicine treat Trial was used were used while worker [DOI] 10.3389/fpubh.2021.723118 PMC 바로가기 [Article Type] Public Health
The MEK1/2-inhibitor ATR-002 efficiently blocks SARS-CoV-2 propagation and alleviates pro-inflammatory cytokine/chemokine responsesMEK1/2 억제제 ATR-002는 SARS-CoV-2 전파를 효율적으로 차단하고 전염증성 사이토카인/케모카인 반응을 완화합니다Original Article Published on 2022-01-102022-09-10 Journal: Cellular and Molecular Life Sciences [Category] 치료제, [키워드] accelerated activate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alleviate anti-influenza drug Anti-SARS-CoV-2 Activity antiviral drug ATR-002 block cascade caused Cell Cell culture cell line cell lines clinical trial clinical trials coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 progression cultures Cytokines death Disease progression Drug evaluation early infection epithelial epithelial cell evaluated expression fibrosarcoma high-risk patient High-risk patients hyperinflammation impair Infection inhibitor kinase kinases knockdown limit medication MEK1/2-inhibitor mitogen mitogen-activated protein kinase Novel coronavirus observé pandemic pandemic spread pathway powerful tool Prevent pro-inflammatory pro-inflammatory cytokines Protein Raf/MEK/ERK respiratory response Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 propagation selective severe acute respiratory syndrome Coronavirus Signaling specific inhibitor Spread supplementary material Symptom target therapeutic intervention Treatment upstream vaccination virus replication while [DOI] 10.1007/s00018-021-04085-1 PMC 바로가기 [Article Type] Original Article
Effectiveness and feasibility of telerehabilitation in patients with COVID-19: a protocol for a systematic review and meta-analysisCOVID-19 환자의 텔레 호출의 효과 및 타당성 : 체계적인 검토 및 메타 분석을위한 프로토콜Article Published on 2022-01-062022-08-31 Journal: BMJ Open [Category] meta-analysis, SARS, [키워드] 95% CI adverse events alleviate analysed Behavioural intervention behavioural interventions Cardiopulmonary Cochrane Library collaboration completion rate Controlled trial controlled trials COVID-19 database Direct effective Effectiveness Ethical approval Ethics evaluate events exercise Factors feasibility functional functional capacity Google Scholar heterogeneity highlight IMPROVE inception include infected with COVID-19 life management mean difference Meta-analysis mortality rate outcome p value Patient patients with COVID-19 peer-reviewed Physiotherapy Primary outcome Primary outcomes PROSPERO protocol Quality of life Randomised controlled trials reason reason for recent registration number rehabilitation rehabilitation medicine required respiratory review risk of bia Risk of bias Safe Satisfaction Science Science Direct searched secondary Secondary outcomes sleep quality statistical analysis Symptom systematic review Telemedicine telerehabilitation Treatment used to calculate variables Web of Science Withdrawal [DOI] 10.1136/bmjopen-2021-058932 PMC 바로가기 [Article Type] Article
COVID-19 Vaccine Hesitancy and Acceptance Among Individuals With Cancer, Autoimmune Diseases, or Other Serious Comorbid Conditions: Cross-sectional, Internet-Based SurveyOriginal Paper Published on 2022-01-052022-10-31 Journal: JMIR Public Health and Surveillance [Category] COVID-19, SARS, [키워드] acceptance affected age alleviate Attitude Autoimmune disease Autoimmune diseases automatically Cancer Care Community comorbid condition comorbid conditions Comorbidities Comorbidity conditions conducted country COVID-19 COVID-19 vaccination COVID-19 vaccine cross-sectional determine disseminate enrolled excluded expressed Factor Health Hesitancy incidence independent predictor individual Influenza information injection Local lung media median age Multivariable regression analysis objective Odds ratio Other Patients with cancer Perception Population predictor Prevalence random Reactions Regulatory remained respondent response responsible Result Safety SARS-CoV-2 self-reported systemic Side effect survey the United State the vaccine Trial vaccination Vaccine Vaccine development Vaccine hesitancy Vulnerable [DOI] 10.2196/29872 PMC 바로가기 [Article Type] Original Paper
Automatic Segmentation of Novel Coronavirus Pneumonia Lesions in CT Images Utilizing Deep-Supervised Ensemble Learning NetworkMedicine Published on 2022-01-032022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] alleviate annotation annotations assist Automatic Coronavirus pneumonia COVID-19 COVID-19 lesion segmentation dataset deep learning deep-supervised ensemble learning network Diagnosis Effectiveness experiment Experimental result feature Image indicated intersection over union learning lesion living environment Local local and global features network novel coronavirus disease novel coronavirus pneumonia overcome overfitting Quantitative Segmentation Spread transfer transfer learning Treatment under CT imaging [DOI] 10.3389/fmed.2021.755309 PMC 바로가기 [Article Type] Medicine
Psychological Symptoms in COVID-19 Patients: Insights into Pathophysiology and Risk Factors of Long COVID-19Review Published on 2022-01-022022-10-28 Journal: Biology [Category] COVID-19, [키워드] ACE-2 acute respiratory syndrome affecting alleviate angiotensin-converting enzyme 2 Anxiety appear articles association Brain Cell Central nervous system CNS complex Complication concerning consequence Consequences coronavirus COVID-19 COVID-19 infection Depression disorders epithelial cells etiology Evidence Factor Factors female gender General population Health immune immune inflammatory signaling immune response implication IMPROVE include Infection inflammatory signaling insight Long mechanism mechanisms mental health MERS Middle East Mounting multifactorial Neuropsychiatric Outbreaks Post-traumatic stress disorder Post-traumatic stress disorder (PTSD) presenting Prevalence prevalence rate Psychiatric psychiatric disorder Psychological psychological symptom psychological symptoms psychotropic medications PTSD receptor risk risk factor Safe SARS-CoV-2 shown simple survivor Survivors syndrome the SARS-CoV-2 therapeutic intervention therapeutic option these symptoms Treatment Variation [DOI] 10.3390/biology11010061 PMC 바로가기 [Article Type] Review
Novel multi-site graph convolutional network with supervision mechanism for COVID-19 diagnosis from X-ray radiographsResearch article Published on 2022-01-012022-10-05 Journal: Applied Soft Computing [Category] 바이오마커, [키워드] Accuracy addition adopted affected alleviate Biomarker Blood Chest computed tomography chest X-ray radiographs Classifier collected Coronavirus disease 2019 COVID-19 COVID-19 diagnosis COVID-2019 dataset datasets deficiency diagnose Diagnosis Effectiveness experiment Extensive global pandemic healthy include information initial limitation mechanism Multi-site graph convolutional network novel nucleic acid test outlier overcome overfitting performed positive researcher resources Result Supervision mechanism suppress the antibody the disease transfer Transmissibility VGG-16 network virus X-ray [DOI] 10.1016/j.asoc.2021.108041 [Article Type] Research article
Specific inhibition of the NLRP3 inflammasome suppresses immune overactivation and alleviates COVID-19 like pathology in miceNLRP3 인플라마좀의 특정 억제는 면역 과잉 활성화를 억제하고 생쥐의 병리와 같은 COVID-19를 완화합니다Article Published on 2021-12-312022-09-11 Journal: EBioMedicine [Category] SARS, 유전자 메커니즘, 진단, [키워드] activated Activation advance alleviate biosafety level BSL-3 Bureau C57BL/6 CAS Cell culture cell cultures conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 severity Cytokines education Evidence finding funding global public health histological host gene Host immune response human ACE2 immune immunofluorescence analysis immunopathology indicated inhibition inhibitor injected Intervention intranasally intraperitoneally Invasion involved knockout mice Laboratory level 3 live SARS-CoV-2 Lung inflammation lung tissue lung tissues Lungs macrophages MCC950 mice NLRP3 NLRP3 inflammasome pandemic pathology performed pro-inflammatory cytokine pro-inflammatory cytokines Program provided quantitative real-time PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2, NLRP3 inflammasome, Immune overactivation, Cytokine storm Science severe COVID-19 disease severe COVID-19 patient severe COVID-19 patients severe pathology severity Specific supported suppresse targeting THP-1 tissues transgenic mice Vaccine development Viral was reduced West wild-type with COVID-19 [DOI] 10.1016/j.ebiom.2021.103803 PMC 바로가기 [Article Type] Article