Effective high-throughput RT-qPCR screening for SARS-CoV-2 infections in children소아에서 SARS-CoV-2 감염에 대한 효과적인 고처리량 RT-qPCR 스크리닝Article Published on 2022-06-252022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] Alpha Alpha variant approach children class correlated delta variant Deprivation diagnosed effective Frequency Germany incidence indicated individual Infection infection control Local Non-invasive positive powerful tool RT-qPCR SARS-CoV-2 SARS-CoV-2 detection SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 surveillance SARS-CoV-2 testing School Schools sensitivities sensitivity statistical Support Surveillance tested variant Viral load viral loads [DOI] 10.1038/s41467-022-30664-2 PMC 바로가기 [Article Type] Article
COVID-19 outbreak in vaccinated patients from a haemodialysis unit: antibody titres as a marker of protection from infection혈액 투석실에서 예방 접종을 받은 환자의 COVID-19 발생: 감염으로부터 보호하는 지표로서의 항체 역가Article Published on 2022-06-232022-09-11 Journal: Nephrology, dialysis, transplantation : official p [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha Alpha variant anti-S anti-S IgG Anti-spike Antibody titre BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccination BNT162b2 vaccine Casirivimab cause Clinical data Combination confidence interval coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 infection COVID-19 outbreak dialysis dialysis room Haemodialysis humoral Humoral response identify IgG Imdevimab immune correlate immune correlates Immunoglobulin Immunoglobulin G Immunosuppression increased risk Infection interquartile range IQR marker monoclonal antibodies monoclonal antibody mRNA vaccination multivariable analysis neutralization Odds ratio outbreak Patient patients prevented recorded reduced respiratory SARS-CoV-2 SARS-COV-2 infection serological response severe acute respiratory syndrome Coronavirus severe coronavirus disease severe COVID-19 severe disease the patient titre treated uninfected vaccination Vaccines variant were infected with COVID-19 [DOI] 10.1093/ndt/gfac016 PMC 바로가기 [Article Type] Article
Increased risk of severe COVID-19 in hospitalized patients with SARS-CoV-2 Alpha variant infection: a multicentre matched cohort studySARS-CoV-2 알파 변종 감염으로 입원한 환자에서 심각한 COVID-19 위험 증가: 다기관 일치 코호트 연구Multicenter Study Published on 2022-06-132022-09-11 Journal: BMC Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI Admission age Alpha variant Analysis both groups cohort study Comorbidities Comorbidity conducted COVID-19 Data collection defined Factor France higher odd higher odds Hospitalization Hospitalized hospitalized patient hospitals in both group Increased lineages logistic regression model male median age multicentre non-rebreather mask participant Patient patients hospitalized primary endpoint proportion retrospective risk SARS-CoV-2 severe COVID-19 severity severity of COVID-19 Sex stratified the disease variant Variant of concern Alpha. VoC [DOI] 10.1186/s12879-022-07508-x PMC 바로가기 [Article Type] Multicenter Study
Evaluating the Neutralizing Ability of a CpG-Adjuvanted S-2P Subunit Vaccine Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants of Concern중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 우려 변종에 대한 CpG-보강 S-2P 소단위 백신의 중화 능력 평가Article Published on 2022-06-102022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), MERS, SARS, 변종, 비임상, 진단, [키워드] Ability acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against Alpha Alpha variant aluminum aluminum hydroxide antibody Antigen Beta Beta variant beta variants breath clinical trial coated with concern coronavirus coronavirus 2 COVID-19 CpG D614G demonstrated dose effective Effectiveness elicit elicited Evaluating High dose Human humans hydroxide immune response immunization immunized immunogenicity medium neutralization neutralization ability neutralization activity Neutralizing antibodies neutralizing antibody neutralizing capacity Neutralizing titer neutralizing titers Phase 1 prefusion pseudovirus pseudoviruses RAT RATs reduced reduction reduction in respiratory retained S-2P SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants serum antibodies serum antibody serum sample serum samples severe acute respiratory syndrome Coronavirus significantly Spike protein subject subunit subunit SARS-CoV-2 vaccine the SARS-CoV-2 Vaccine Vaccines variant variant of concern variants VOCs wild-type [DOI] 10.1093/cid/ciab711 PMC 바로가기 [Article Type] Article
Sequential Appearance and Isolation of a SARS-CoV-2 Recombinant between Two Major SARS-CoV-2 Variants in a Chronically Infected Immunocompromised Patient만성 감염 면역저하 환자에서 두 가지 주요 SARS-CoV-2 변이체 간의 SARS-CoV-2 재조합체의 순차적인 출현 및 분리Article Published on 2022-06-102022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Alpha variant Analysis analyzed appearance backbone chronic infection Combination combinations concurrent infection Coronaviruses Follow-up genetic recombination Genome genomes genomic Genomic surveillance humans Immunosuppression infecting Infection initial lymphoma Major mechanism mutant Mutation Next-generation sequencing parental Patient PCR predominant recombinant Recombination reported RNA viruses SARS-CoV-2 SARS-CoV-2 variants Seven spike gene Surveillance the patient variant variants virus viruses was obtained [DOI] 10.3390/v14061266 PMC 바로가기 [Article Type] Article
Variant-driven early warning via unsupervised machine learning analysis of spike protein mutations for COVID-19COVID-19에 대한 스파이크 단백질 돌연변이의 감독되지 않은 기계 학습 분석을 통한 변이 기반 조기 경고Article Published on 2022-06-032022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Algorithm Alpha variant Analysis approach Birth Cluster Clustering collected connection correlation COVID-19 dataset Delta demonstrated described dominance Effectiveness epidemiological epidemiological data Epidemiology event Evolution Genome sequencing group highlight host cells Hypothesis identify introduced Lineage machine learning analysis Mutation occur offer pandemic predict Protein protein sequences real time Replication sequence Spike protein Spread the Spike to define variant variants variants of concern variants of interest viral outbreak virus Virus evolution yielding [DOI] 10.1038/s41598-022-12442-8 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infections in mRNA vaccinated individuals are biased for viruses encoding spike E484K and associated with reduced infectious virus loads that correlate with respiratory antiviral IgG levelsmRNA 백신을 접종한 개인의 SARS-CoV-2 감염은 스파이크 E484K를 인코딩하는 바이러스에 대해 편향되어 있으며 호흡기 항바이러스성 IgG 수준과 상관관계가 있는 감소된 감염성 바이러스 부하와 관련이 있습니다.Article Published on 2022-06-012022-09-11 Journal: Journal of Clinical Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제, [키워드] A significant reduction accompanied Alpha Alpha variant Amino acid Analysis Anti-viral Antiviral association B.1.1.7 B.1.526 BNT162b2 Breakthrough infection breakthrough infections caused Cell culture change Cohort collected COVID-19 cycle threshold dose E484K early phase ELISA examined Genome ICU admission IgG IgG level IgG levels immunization increase in Infectious virus investigated Lineage Moderna molecular Mortality mRNA mRNA-1273 PCR Pfizer-BioNTech positive positive sample Positive test predominant Protein reduce reduced required respiratory respiratory sample Respiratory samples Sample SARS-CoV-2 SARS-CoV-2 IgG antibody SARS-COV-2 infection SARS-CoV-2 positive patient sequenced Sequencing specimen specimens spike Spike protein symptomatic infection symptomatic infections upper respiratory tract vaccinated individual vaccinated individuals vaccination Vaccines variant Viral Viral load viral loads viral variant virus were used whole genome [DOI] 10.1016/j.jcv.2022.105151 PMC 바로가기 [Article Type] Article
Epidemiological and genomic findings of the first documented Italian outbreak of SARS-CoV-2 Alpha variant of concern우려되는 SARS-CoV-2 Alpha 변이체의 이탈리아 최초 발병 사례에 대한 역학 및 게놈 연구 결과Article Published on 2022-06-012022-09-11 Journal: Epidemics [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Abruzzo Alpha variant Alpha VOC Analysis calculated clade Contact diffusion epidemiological data Epidemiology genomic Genomic analysis Genomic surveillance GISAID database identity Italian network outbreak random referred to reproduction Reproduction number SARS-CoV-2 SARS-CoV-2, Alpha variant. sequence sequences subset town transmission parameters VoC [DOI] 10.1016/j.epidem.2022.100578 PMC 바로가기 [Article Type] Article
A Model for Highly Fluctuating Spatio-Temporal Infection Data, with Applications to the COVID EpidemicCOVID 전염병에 대한 적용과 함께 변동이 심한 시공간 감염 데이터에 대한 모델Article Published on 2022-05-302022-09-11 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 변종, [키워드] adaptive adopted Alpha variant alternation application autoregressive case study coefficient COVID Endemic endemicity England Epidemic expected feature Fluctuating followed by implication Infection infection level infection levels London Metrics Model Poisson model regime-switching short term spatio-temporal spillover Spread the epidemic transformations [DOI] 10.3390/ijerph19116669 PMC 바로가기 [Article Type] Article
Vaccination with BNT162b2 and ChAdOx1 nCoV-19 Induces Cross-Reactive Anti-RBD IgG against SARS-CoV-2 Variants including OmicronBNT162b2 및 ChAdOx1 nCoV-19 백신 접종은 Omicron을 포함한 SARS-CoV-2 변이체에 대한 교차 반응성 항-RBD IgG를 유도합니다Article Published on 2022-05-282022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료법, [키워드] adaptive Adaptive immunity age Alpha Alpha variant anti-RBD BNT162b2 booster vaccinations Breakthrough infection breakthrough infections caused ChAdOx1 ChAdOx1 nCoV-19 Cohort contribute Course COVID-19 cross-reactive cross-reactive antibodies cross-reactivity Delta delta variant domain ELISA explain Gamma health-care IgG IgG ELISA IgG level IgG levels Immunity independent independent of individual Infection infection rate lethality magnitude morbidity nucleocapsid nucleocapsid IgG omicron Omicron variants RBD RBD IgG reactivity Receptor-binding domain Receptor-binding domain (RBD) recipient SARS-CoV-2 SARS-CoV-2 testing SARS-CoV-2 variants sera Sex significant increase significantly higher significantly lower Spike protein Spread tested the spike protein university vaccination vaccination rate Vaccine variants variants of concern Vienna VoC VOCs was increased while [DOI] 10.3390/v14061181 PMC 바로가기 [Article Type] Article