Optimizing a Protocol to Assess Immune Responses after SARS-CoV-2 Vaccination in Kidney-Transplanted Patients: In Vivo DTH Cutaneous Test as the Initial Screening MethodCommunication Published on 2021-11-122022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] anti-Spike IgG can be used Cellular immune response classical complement control patients correlation COVID19 Cutaneous delayed-type hypersensitivity dose DTH evaluated hypersensitivity IgG immunized Immunocompromised patient Immunosuppression in vitro in vivo interferon gamma kidney transplant mRNA-based natural infection Patient patients Pfizer–BioNTech positive recipient response SARS-CoV-2 Screening second dose shown Skin test T-cell T-cell functionality T-cell Response Test the spike protein the vaccine vaccinated individuals vaccination Vaccine was determined [DOI] 10.3390/vaccines9111315 PMC 바로가기 [Article Type] Communication
Robust and Persistent B- and T-Cell Responses after COVID-19 in Immunocompetent and Solid Organ Transplant Recipient Patients면역 적합성 및 고체 장기 이식 수용자 환자에서 COVID-19 후 강력하고 지속적인 B- 및 T- 세포 반응Article Published on 2021-11-112022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] analysed anti-Nucleocapsid IgG anti-Spike IgG antibody Antibody Response Antibody responses assays CD4 CD8 comparable COVID-19 Cytokines declined determined by develop elicited ELISA envelope envelope protein IgA IgG immune response immunocompetent patients Immunocompromised Immunocompromised patient Immunocompromised patients induced Infection lymphoproliferative membrane membrane protein mild symptoms Neutralization assay Neutralizing antibodies neutralizing antibody nucleocapsid protein Nucleocapsid proteins organ Patient patients patients with pneumonia peptide peptide pool peptide pools persistence persistent Pneumonia proliferative Protein recipient response SARS-CoV-2 SARS-COV-2 infection Solid solid organ spike Spike protein Stimulation T-cell Response T-cell responses the Spike Transplant transplanted patients was determined [DOI] 10.3390/v13112261 PMC 바로가기 [Article Type] Article
Immunogenicity and reactogenicity of BNT162b2 booster in BBIBP-CorV-vaccinated individuals compared with homologous BNT162b2 vaccination: Results of a pilot prospective cohort study from Lebanon상동 BNT162b2 백신과 비교하여 BBIBP-CorV 백신을 접종한 개인에서 BNT162b2 부스터의 면역원성 및 반응성: 레바논의 파일럿 전향 코호트 연구 결과Article Published on 2021-11-052022-09-11 Journal: Vaccine [Category] SARS, 변종, [키워드] 95%CI Administered anti-Spike IgG BBIBP-CorV BNT162b2 booster booster dose booster vaccination ChAdOx1 ChAdOx1-S Combination conducted country COVID-19 dose Effectiveness elicited General Hospital geometric mean geometric mean titer heterologous immunization homologous Homologous immunization immunization immunogenicity individual Lebanon. mRNA vaccine mRNA vaccines of BNT162b2 overcome Population prospective cohort study reactogenicity Result Safe significantly tested the vaccine vaccination Vaccine variants [DOI] 10.1016/j.vaccine.2021.10.007 PMC 바로가기 [Article Type] Article
Safety and cross-variant immunogenicity of a three-dose COVID-19 mRNA vaccine regimen in kidney transplant recipients신장 이식 수혜자에서 3회 접종 COVID-19 mRNA 백신 요법의 안전성 및 교차 변이 면역원성Article Published on 2021-11-012022-09-11 Journal: EBioMedicine [Category] MERS, SARS, 변종, 진단, [키워드] anti-Spike IgG antibody Antigen BNT162b2 BNT162b2 vaccine Cell cells cellular response Cellular responses COVID-19 COVID-19 vaccine cytokine cytokine production delta variant dose doses explained Frequency Heterologous homologous IFN-γ IFN-γ response IFN-γ responses IgG immunogenicity immunosuppressive immunosuppressive therapy increase interferon kidney Kidney function kidney transplant kidney transplant recipient longitudinal study Mild mRNA mRNA vaccine neutralization activity Neutralizing activity neutralizing antibody Nice University Hospital one patient Patient PBMC PBMCs performed raised reaction Reactions recipient recipients regimen remained Safety second dose Seroconversion seronegative significant increase spike-specific IgG tested therapy Tolerability university Vaccine variants variants of concern variants of concern, kidney transplantation. [DOI] 10.1016/j.ebiom.2021.103679 PMC 바로가기 [Article Type] Article
Anti-spike antibody response to natural SARS-CoV-2 infection in the general population일반 인구에서 자연적인 SARS-CoV-2 감염에 대한 항스파이크 항체 반응Article Published on 2021-10-292022-09-12 Journal: Nature Communications [Category] MERS, SARS, 진단, [키워드] anti-spike antibodies anti-Spike IgG antibody antibody levels Antibody Response Antibody responses average Bayesian booster Community COVID-19 infection Cycle threshold value determinant determinants Epidemiology estimate feature female General population immune response infected with SARS-CoV-2 Infection latent class less linear MOST Older participant PCR tests peak level Planning positive swab Reinfection reported responders risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 PCR test seroconvert seroconverted Severe infection subsequent Symptoms the antibody response trajectory understanding United Kingdom vaccination viral burden viral infection [DOI] 10.1038/s41467-021-26479-2 PMC 바로가기 [Article Type] Article
B Cell Response Induced by SARS-CoV-2 Infection Is Boosted by the BNT162b2 Vaccine in Primary Antibody DeficienciesSARS-CoV-2 감염에 의해 유도된 B 세포 반응은 1차 항체 결핍에서 BNT162b2 백신에 의해 촉진됩니다Article Published on 2021-10-272022-09-12 Journal: Cells [Category] MERS, SARS, 진단, [키워드] analyzed anti-Spike IgG Antibody Response Atypical B cell response BNT162b2 BNT162b2 vaccine Cell classical common variable immunodeficiencies convalescent convalescent patient COVID-1 COVID-19 pandemic CVID deficiency dose IgG immune response immunization immunized immunodeficiency immunological induced Infection memory B memory B cell memory B cells natural Patient Poor primary antibody Reactions response risk SARS-CoV-2 SARS-COV-2 infection Spike protein Spike-specific antibody spike-specific T cell stimulate subsequent T cell response T cells third dose vaccination Vaccine vaccine dose were measured [DOI] 10.3390/cells10112915 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Vaccine Induced Atypical Immune Responses in Antibody Defects: Everybody Does their Best항체 결함에서 SARS-CoV-2 백신 유도 비정형 면역 반응: 모두가 최선을 다합니다Original Article Published on 2021-10-202022-09-12 Journal: Journal of Clinical Immunology [Category] MERS, SARS, 진단, [키워드] agammaglobulinemia age-matched control analyzed Anti-spike anti-Spike IgG antibody production Antibody Response Atypical B-cell B-cells binding domain BNT162b2 BNT162b2 vaccine Cohort common Common variable immune deficiencies COVID-19 CVID detectable generate Germinal center healthy heterogeneous IgA IgG immune response immune responses immunization induced infected patient infected patients infected with SARS-CoV-2 Infection memory Memory cells naïve occurred of BNT162b2 one patient Patient patients Primary antibody deficiencies raising RBD Reactions Receptor-binding-domain Reinfection response Result SARS-CoV-2 SARS-COV-2 infection second dose Seven Specific specificity Spike protein spike-specific IgG subsequent supplementary material T-cell T-cell Response T-cells undetectable vaccination Vaccine vaccine dose variable while X-linked X-linked agammaglobulinemia XLA [DOI] 10.1007/s10875-021-01133-0 PMC 바로가기 [Article Type] Original Article
The autoimmune signature of hyperinflammatory multisystem inflammatory syndrome in children소아에서 과염증성 다기관 염증 증후군의 자가면역 시그니처Article Published on 2021-10-152022-09-11 Journal: The Journal of Clinical Investigation [Category] 바이오마커, 유전자 메커니즘, [키워드] Admission Analysis anti-Spike IgG antigenic antigens autoantibodies autoantibody autoantigen Autoimmune Autoimmune diseases Autoimmunity B cell BCR Cellular immune response children Cluster Coagulation coagulation pathways Combination complement contributing to COVID-19 Cytokines expressed Factor Genes heavy chain humoral immune responses Hyperinflammatory identify IgG IGHV immune immune responses Immunoglobulin Immunopathogenesis Inflammation inflammation markers Inflammatory Inflammatory response intensive care intensive care unit admission manifestation Mild MIS-C Multiorgan neutrophil neutrophil activation neutrophil response pathogenic pathway Patient Previous studies previous study proteomics receptor RNA sequencing SARS-COV-2 infection sequence Sequencing serum superantigen syndrome T cell T cell receptor TCR tissue damage TRBV11-2 Treatment Usage variable region [DOI] 10.1172/JCI151520 PMC 바로가기 [Article Type] Article
Humoral response after SARS-CoV-2 mRNA vaccines in dialysis patients: Integrating anti-SARS-CoV-2 Spike-Protein-RBD antibody monitoring to manage dialysis centers in pandemic times투석 환자에서 SARS-CoV-2 mRNA 백신 후 체액 반응: 전염병 시대에 투석 센터를 관리하기 위해 항-SARS-CoV-2 스파이크-단백질-RBD 항체 모니터링 통합Research Article Published on 2021-10-052022-09-12 Journal: PLoS ONE [Category] MERS, SARS, 진단, [키워드] absence active cancer age Analysis anti-SARS-CoV-2 Anti-spike anti-Spike IgG antibody Antibody Response benefit BNT162b2 dialysis dose doses effective elicit Factor highest Humoral response identify IgG immune response Immunocompromised immunocompromised status inhibitors lack lymphocyte management mandatory Most patients mRNA vaccine pandemic Patient RAAS RBD Retrospective analysis revaccination risk SARS-CoV-2 SARS-COV-2 infection Seroconversion status Vaccine [DOI] 10.1371/journal.pone.0257646 PMC 바로가기 [Article Type] Research Article
BNT162b2 Vaccination Elicits Strong Serological Immune Responses Against SARS-CoV-2 Including Variants of Concern in Elderly ConvalescentsBNT162b2 백신 접종은 노인 요양기의 우려 변종을 포함하여 SARS-CoV-2에 대한 강력한 혈청학적 면역 반응을 이끌어냅니다Observational Study Published on 2021-09-292022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 임상, 진단, [키워드] Against age analyzed anti-Spike IgG Antibody titer Antibody titers B.1.1.7 B.1.351 benefit binding domain BNT162b2 Care Comirnaty concern convalescent individual COVID-19 COVID-19-convalescent individual cross-reactive Efficacy elderly End End points Gender IgA titer IgA titers IgG titers immune response immune responses Including individual Long-term care MOST mRNA vaccine mutated neutralization capacity neutralization test Neutralizing neutralizing capacity P.1 pre-vaccination prospective observational cohort response SARS-CoV-2 SARS-CoV-2 receptor serological serum significantly higher strength Strong subject vaccination Vaccine vaccinees variants of concern VOCs [DOI] 10.3389/fimmu.2021.743422 PMC 바로가기 [Article Type] Observational Study