A review on computational approaches that support the researches on traditional Chinese medicines (TCM) against COVID-19COVID-19에 대한 전통적인 중국 의약품 (TCM)에 대한 연구를 지원하는 계산 접근법에 대한 검토Review Published on 2022-09-012022-08-31 Journal: Phytomedicine : international journal of phytother [Category] 신약개발, 치료제, [키워드] antiviral agent Antiviral agents antiviral medication applied approach approaches article articles artificial intelligence AutoDock AutoDock vina category caused Chinese collected complex mechanism complex mechanisms Compound computational approach Computational approaches computational method contagious infection contagious infections COVID-19 database death Direct direct-acting Diseases disrupting Drug discovery effort eligible examined exclusion criteria Google Scholar Gromacs help highlight include Inclusion Knowledge-mining lead MD simulation Medicine molecular docking molecular mechanism Network-based approach other diseases Prevention and control Prophylactic provided required Research ResearchGate resource retrieved Science Science Direct Structure-based approach Support targets TCM TCMSP Traditional Traditional Chinese medicine traditional Chinese medicine (TCM) Vaccine Web of Science [DOI] 10.1016/j.phymed.2022.154324 PMC 바로가기 [Article Type] Review
Effects of bioactive compounds from Pleurotus mushrooms on COVID-19 risk factors associated with the cardiovascular systemReview article Published on 2022-09-012022-10-05 Journal: Journal of integrative medicine [Category] 치료제, [키워드] Anti-inflammatory antioxidant Antiviral agents cardiovascular system component Compound Concentration coronavirus coronavirus disease COVID-19 COVID-19 severity disease Effect Food supplements fungi highlight immune health Infectious disease metabolism metabolites mushroom pharmacological agents Pleurotus protective mechanism reduction in risk factor SARS-CoV-2 severity significantly therapeutic therapeutic potential tissue Treatment Vitamin [DOI] 10.1016/j.joim.2022.07.002 [Article Type] Review article
Antiviral plant-derived natural products to combat RNA viruses: Targets throughout the viral life cycleArticle Published on 2022-09-012022-11-15 Journal: Letters in Applied Microbiology [Category] SARS, 치료제, [키워드] Antiviral antiviral activity Antiviral agents antiviral drug antivirals clinical trial Compound Drug discovery effective Efficacy evaluate in vivo mechanism mechanism of action natural product phytochemical plant plant. Research RNA RNA virus RNA viruses SARS-CoV-2 Stage target therapeutic potential Toxicity viral life cycle virus [DOI] 10.1111/lam.13637 PMC 바로가기
Clinical characteristics and treatment outcomes of SARS-CoV-2 delta variant outbreak, Pingtung, Taiwan, June 2021Article Published on 2022-09-012022-11-15 Journal: Journal of the Formosan Medical Association = Taiw [Category] SARS, 변종, 치료제, [키워드] antiviral agent Antiviral agents Aspartate aminotransferase AST Characteristics clinical Clinical characteristics Coronavirus disease 2019 cough COVID-19 cycle threshold defined Delta delta variant demonstrated Diagnosis disease evaluated ferritin Fever headache hospital Infection lactate dehydrogenase LDH mechanical ventilation median Mortality occurred outbreak Patient Pingtung Pneumonia polymerase chain real-time reverse transcriptase repeated risk factor RT-PCR SARS-CoV-2 SARS-CoV-2 delta SARS-COV-2 infection serum Symptom symptomatic Taiwan Treatment Treatment outcome Two patient variant viral shedding [DOI] 10.1016/j.jfma.2022.01.008 PMC 바로가기
Artificially expanded genetic information systems (AEGISs) as potent inhibitors of the RNA-dependent RNA polymerase of the SARS-CoV-2SARS-CoV-2의 RNA 의존성 RNA 중합효소의 강력한 억제제로서 인공적으로 확장된 유전 정보 시스템(AEGIS)Article Published on 2022-09-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 유전자 메커니즘, 치료제, [키워드] AEGIS affected Antiviral agents antiviral agents. binding binding site candidate COVID-19 drug Economy examined genetic information help host cells identify in vivo Infection Information Systems inhibit inhibitor ligands MD simulations mechanism molecular docking monophosphate nucleotide nucleotides Original position outbreak pandemic potential therapeutic agent potential therapeutic agents RdRP RDV Remdesivir Replication responsible RNA RNA-dependent RNA polymerase SARS-CoV-2 SARS-COV-2 infection sequence shown the SARS-CoV-2 therapeutic toxicities Toxicity Transmission unavailability Viral RNA virus [DOI] 10.1080/07391102.2021.1883112 PMC 바로가기 [Article Type] Article
In silico identification and validation of natural antiviral compounds as potential inhibitors of SARS-CoV-2 methyltransferaseSARS-CoV-2 메틸트랜스퍼라제의 잠재적 억제제로서의 천연 항바이러스 화합물의 실리코(in silico) 식별 및 검증Article Published on 2022-09-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] Coronavirus, SARS, 치료제, [키워드] acute respiratory syndrome coronavirus amentoflavone Analysis analyzed Antiviral agents Antiviral compounds Antiviral natural compounds approach baicalin binding mechanism caused complex Compound coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 treatment Daidzin docking Effect In silico methods indicated inhibit inhibitor inhibitors of SARS-CoV-2 Interaction MD simulation methyltransferase molecular molecular docking molecular dynamic simulation molecular dynamics Molecular dynamics simulation MTase natural antiviral Novel coronavirus novel coronavirus disease offer outbreak parameter Probability resource respiratory SARS-CoV-2 selected severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 stability Substitution the SARS-CoV-2 therapeutic Therapeutics these compound these compounds Trajectories treat Treatment treatment of COVID-19 unavailability vaccination Virtual screening was performed [DOI] 10.1080/07391102.2021.1886174 PMC 바로가기 [Article Type] Article
Chronic Hepatitis B Viral Activity Enough to Take Antiviral Drug Could Predict the Survival Rate in Malignant LymphomaArticle Published on 2022-08-312023-06-11 Journal: Viruses [Category] B형 간염, [키워드] Antiviral agents extrahepatic malignancy HBV DNA integration Hepatitis B virus Liver cirrhosis malignant lymphoma viral activity. [DOI] 10.3390/v14091943 PMC 바로가기
Summary of Guidance for Minimizing the Impact of COVID-19 on Individual Persons, Communities, and Health Care Systems – United States, August 2022Article Published on 2022-08-192022-11-15 Journal: Morbidity and Mortality Weekly Report [Category] SARS, 변종, 치료제, [키워드] acute illness age Antiviral agents approach Care cause CDC changes in circulating variants conditions COVID-19 COVID-19 illness current death effective effort expand exposure Health high risk Hospitalization Immunity Immunocompromised Impact increase individual Infection information Mask measure Measures medical condition monoclonal antibodies nonpharmaceutical intervention Nonpharmaceutical interventions preexposure prophylaxis Prevent PROTECT public health receive recommendation reduce reduced reducing Respirator risk SARS-CoV-2 symptomatic System therapeutic Treatment United States vaccination Vaccine Vaccines Ventilation virus [DOI] 10.15585/mmwr.mm7133e1 PMC 바로가기
In Silico and In Vitro Studies of Alchemilla viridiflora Rothm-Polyphenols’ Potential for Inhibition of SARS-CoV-2 InternalizationAlchemilla viridiflora Rothm-Polyphenols의 SARS-CoV-2 내재화 억제 가능성에 대한 실리코 및 체외 연구Article Published on 2022-08-142022-09-11 Journal: Molecules [Category] SARS, 변종, [키워드] ACE2 Alchemilla viridiflora Rothm. angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral agents binding binding energy binding interaction Compound computational studies Computational study Contact COVID-19 COVID-19 pandemic dose doses E484K effective Effectiveness exhibited flavonoid G476S glycoprotein Health higher affinity highest in silico in vitro inhibited inhibition internalization investigated K417N methanol molecular docking studies Molecular docking study Mutation N439K N501Y neuropilin Neuropilin-1 NRP1 outbreak plants polyphenols Potential Prevent quercetin receptor receptors resulting SARS-CoV-2 SARS-CoV-2 strain selected significantly spike glycoprotein tested V483A virus virus infection Virus spike wild strain [DOI] 10.3390/molecules27165174 PMC 바로가기 [Article Type] Article
Identification, optimization, and biological evaluation of 3-O-β-chacotriosyl ursolic acid derivatives as novel SARS-CoV-2 entry inhibitors by targeting the prefusion state of spike protein스파이크 단백질의 융합 전 상태를 표적으로 하는 신규 SARS-CoV-2 진입 억제제로서의 3-O-β-chacotriosyl ursolic acid 유도체의 식별, 최적화 및 생물학적 평가Article Published on 2022-08-052022-09-11 Journal: European journal of medicinal chemistry [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] antiviral activity Antiviral agents Cavity COVID-19 pandemic Delta derivative effective generate identification Infection inhibitor inhibitors membrane fusion Mutation offer omicron Pentacyclic triterpenoid saponins prefusion pseudotyped SARS-CoV-2 public health S protein S1 and S2 saponins SARS SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 S protein SARS-CoV-2 variant Spike protein subunit the S protein the SARS-CoV-2 Vaccine variant variants Vero-E6 cell Vero-E6 cells virus-cell membrane fusion [DOI] 10.1016/j.ejmech.2022.114426 PMC 바로가기 [Article Type] Article