Persimmon-derived tannin has antiviral effects and reduces the severity of infection and transmission of SARS-CoV-2 in a Syrian hamster model감에서 추출한 탄닌은 항바이러스 효과가 있으며 시리아 햄스터 모델에서 SARS-CoV-2의 감염 및 전염의 심각성을 감소시킵니다.Article Published on 2021-12-082022-09-10 Journal: Scientific Reports [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition administration antioxidant Antiviral effect antiviral effects approach carboxymethyl cellulose caused Cellulose control group coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Donor dose hamster help human-to-human transmission immunology in vitro in vivo models inoculated investigated Microbiology oral administration oral cavity Persimmon Plaque assay Pneumonia Prevent reduce reduced respiratory Saliva SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severity Severity of infection Spread suppressed tannin These data Transmission transmission of SARS-CoV-2 transmitted uninfected virus virus titer virus titers [DOI] 10.1038/s41598-021-03149-3 PMC 바로가기 [Article Type] Article
Antiviral Activity of the Rhamnolipids Mixture from the Antarctic Bacterium Pseudomonas gessardii M15 against Herpes Simplex Viruses and CoronavirusesArticle Published on 2021-12-082022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] activity addition Antarctic bacteria Antiviral antiviral action antiviral activity Antiviral effect Bacteria bacterium being cause Complete compounds Coronaviridae coronavirus Cytopathic effect demonstrated detectable displaying effective enveloped virus HCoV-229E HCoV-OC43 Health Herpe herpes Herpesviridae HSV-1 inactivation investigated less microbial microbial biosurfactants mixture Outbreaks produced Pseudomona Rhamnolipid rhamnolipids SARS-CoV-2 TEM treated Type virus was recorded [DOI] 10.3390/pharmaceutics13122121 PMC 바로가기 [Article Type] Article
Exosomes/microvesicles target SARS-CoV-2 via innate and RNA-induced immunity with PIWI-piRNA systemResearch Article Published on 2021-12-032022-10-30 Journal: Life Science Alliance [Category] COVID-19, MERS, SARS, [키워드] adaptive Antiviral antiviral action Antiviral effect antiviral immunity Cell cell type Immunity In vitro infection increased expression Innate immunity knockout PIWIL2 Protein protein translation provided reduce reductions in RNA RNA fragment SARS-CoV-2 SARS-CoV-2 genome shown stem cell Viral RNA [DOI] 10.26508/lsa.202101240 PMC 바로가기 [Article Type] Research Article
The NSP14/NSP10 RNA repair complex as a Pan-coronavirus therapeutic targetArticle Published on 2021-12-032022-10-31 Journal: Cell Death and Differentiation [Category] COVID-19, COVID19(2023년), SARS, [키워드] Antiviral Antiviral effect antivirals cellular complex DNA repair enzymes Efficacy ENhance exonuclease human coronavirus OC43 in silico in vitro Infectious diseases inhibit inhibitor MERS-CoV Microbiology pandemic Proofreading provide Remdesivir replication of SARS-CoV-2 risk RNA SARS-CoV SARS-CoV-2 Screening sofalcone the SARS-CoV-2 therapeutic target Zoonotic coronavirus [DOI] 10.1038/s41418-021-00900-1 PMC 바로가기 [Article Type] Article
Does prior exposure to immune checkpoint inhibitors treatment affect incidence and mortality of COVID-19 among the cancer patients: The systematic review and meta-analysisResearch article Published on 2021-12-012022-10-05 Journal: International immunopharmacology [Category] 치료법, [키워드] 95% CI 95% confidence interval Affect Antiviral effect bioRxiv Cancer cancer patient Cancer patients Controlled COVID-19 COVID-19 pandemic database Immune checkpoint inhibitor Immune checkpoint inhibitors incidence incidence of COVID-19 increased risk indicated Infection inflammatory storm inhibitor ISI material medRxiv meta-analyses Meta-analysis meta-regression analysis Mortality no significant difference Patient Primary outcome Prospective Study recent reduce Result retrospective risk SARS-CoV2 infection searched secondary outcome selected shown subsequent susceptibility systematic review T cells Treatment [DOI] 10.1016/j.intimp.2021.108242 [Article Type] Research article
Niclosamide for Covid-19: bridging the gapCovid-19용 니클로사미드: 격차 해소Review Published on 2021-12-012022-09-11 Journal: Molecular biology reports [Category] SARS, 치료제, [키워드] acute respiratory distress syndrome angiotensin Angiotensin-converting enzyme anthelminthic Anti-inflammatory anti-inflammatory effect Anti-inflammatory effects anti-SARS-CoV-2 Antiviral antiviral activities Antiviral effect antiviral effects biological processes clinical outcomes clinical study clinical trial clinical trials Concentration concerning COVID-19 COVID-19 severity Cytokines Cytopathic effect Direct disease distress Effect endosomal pH enzyme Google Scholar homeostasis immune in vivo Inflammasome inflammatory signaling inhibit interruption mandatory maturation mechanism modulate modulating mTOR mTOR signaling NCL neutralization NF-κB niclosamide NLRP3 NLRP3 inflammasome oral bioavailability oxidative phosphorylation pandemic pathway Patient pleiotropic pro-inflammatory cytokines Prospective protective role reduce reducing Regulatory respiratory distress Respiratory distress syndrome SARS-CoV-2 SARS-COV-2 infection Science Science Direct serum severity signaling pathway suppression therapeutic therapy treat viral proliferation Viral protein was done Web of Science [DOI] 10.1007/s11033-021-06770-7 PMC 바로가기 [Article Type] Review
ADAR Editing in Viruses: An Evolutionary Force to Reckon withReview Published on 2021-11-252022-10-31 Journal: Genome Biology and Evolution [Category] COVID-19, [키워드] A-to-I editing Act ADAR adenosine adenosine deaminases acting on RNA (ADAR) editing Affect affecting Answering Antiviral Antiviral effect approach Autoimmunity contribute Course Deaminase dependent on Diseases Effect enzyme Factor Factors force functions groups immune response Infection innate immune response Interaction interactions interferon neural function proteome question Research resulting RNA RNA editing RNA viruses SARS-CoV-2 selective transcript Transcriptome turn viral evolution viral infection viral infections viral molecular evolution viral replication virus Zika virus [DOI] 10.1093/gbe/evab240 PMC 바로가기 [Article Type] Review
Metallodrug Profiling against SARS‐CoV‐2 Target Proteins Identifies Highly Potent Inhibitors of the S/ACE2 interaction and the Papain‐like Protease PL proFull Paper Published on 2021-11-232022-10-31 Journal: Chemistry (Weinheim an Der Bergstrasse, Germany) [Category] COVID-19, SARS, [키워드] ACE2 receptor acute respiratory syndrome addition Antiviral Antiviral agents Antiviral effect antiviral therapeutics approved complex complexes Compound compound screening coronavirus drug design Drug discovery evaluated Evidence gold, metallodrugs infected cell inhibitor Interaction ligands mechanisms metal NHC PLpro polyoxometalates potent Profiling protease Protein Replication SARS-CoV-2 SARS‐CoV‐2 selected silver Spike protein Spread starting point target tested the spike protein titanocene [DOI] 10.1002/chem.202103258 PMC 바로가기 [Article Type] Full Paper
Conflicts over calcium and the treatment of COVID-19Commentary Published on 2021-11-232022-11-01 Journal: Evolution, Medicine, and Public Health [Category] COVID-19, [키워드] Antiviral effect antiviral therapy association blocker calcium calcium metabolism CCB CCBs clinical study conflict coronavirus disease COVID-19 demonstrated Effectiveness Efficacy evaluate Evidence Host Hypocalcemia Hypothesis ionized calcium Mortality pathogenicity Pathogens pathology positive Prospective provided reduce mortality reduced SARS-CoV-2 serum severity shown Support Treatment virus virus-infected cells viruses with COVID-19 [DOI] 10.1093/emph/eoaa046 PMC 바로가기 [Article Type] Commentary
TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restrictionTMPRSS2는 NCOA7 매개 제한으로부터 SARS-CoV-2 회피를 촉진합니다Research Article Published on 2021-11-222022-09-10 Journal: PLoS Pathogens [Category] MERS, SARS, 유전자 메커니즘, [키워드] acquisition Activation Antiviral Antiviral effect antiviral effects ATPase biological significance Cell cell surface characterized cleavage coactivator concomitant use consequence coronavirus Critical cytoplasmic dysregulation ectopic expression Effect effector endocytic Endosomal acidification epithelial cells evade furin furin cleavage furin cleavage site gene knockout HCoV HCoV-229E HCoV-NL63 highly pathogenic Host immune response host immune responses IFN IFN treatment IFNs immune responses Inborn errors Infection infections inhibit inhibit SARS-CoV-2 inhibited inhibitor innate immune response innate immune responses interact interferon interferons ISG ISGs isoform lentivirus less Lung epithelial cells lysosomal protease mechanism MERS MERS-CoV NCOA7 NL63 nuclear nuclear receptor option overexpression Particle pathway patients with COVID-19 plasma membrane polybasic promote protease Protein pseudotyped Pseudotyped viruses receptor removal repertoire Research RNA robust SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 spike seasonal severe COVID-19 spike Spike protein Support the interferon TMPRSS TMPRSS2 TMPRSS2 protease Trigger vacuolar Vesicle Viral viral spike protein virus virus entry virus infection virus infections viruses [DOI] 10.1371/journal.ppat.1009820 PMC 바로가기 [Article Type] Research Article