auxiliary
[용어속성] Term
Functional analysis of potential cleavage sites in the MERS-coronavirus spike protein
Article
[키워드] activate
Activation
Analysis
antiviral strategy
arginine
auxiliary
carried
cathepsin L
Cell
cell line
cellular protease
cleavage
cleavage site
cleave
coronavirus
enzyme
Evidence
expressing
furin
host cell
host cell protease
MERS-CoV
MERS-S
Middle East
motif
mutagenic
Mutation
pandemic
potential therapeutic targets
pre-cleavage
processed
protease
recognizing
reported
required
responsible
robust
S protein activation
S protein-driven entry
S1/S2
S1/S2 and S2′
S1/S2 site
S2′ site
sequence
severe disease
Spike protein
subsequent
tested
the S protein
TMPRSS2
vector
viral entry
viral infectivity
viral spike protein
was obtained
[DOI] 10.1038/s41598-018-34859-w PMC 바로가기 [Article Type] Article
[DOI] 10.1038/s41598-018-34859-w PMC 바로가기 [Article Type] Article
Mice Lacking Endoglin in Macrophages Show an Impaired Immune Response
대식세포에서 엔도글린이 결핍된 마우스는 손상된 면역 반응을 보여줍니다
Research Article
[키워드] absence
ACVRL1
analyzed
animals
Antigen
autosomal dominant
autosomal dominant disorder
auxiliary
Bacteria
balance
blood monocyte
blood monocytes
C57BL/6
cell line
characterized
conditions
contribute
deficiency
described
develop
differentiation
disorder
dominant
dysplasia
Endoglin
endotoxin
ENG
explain
expressed
expression
foci
function
help
hemorrhage
hemorrhages
Hereditary
Hereditary hemorrhagic telangiectasia
homeostasis
human cell
human macrophages
immune
immune response
Impaired
in vitro
in vivo
increased survival
Infection
infection rate
Infectious disease
Infectious diseases
Inflammation
internal organs
knock-out
Laboratory
leukemic
leukemic cell
Lineage
Macrophage
macrophages
malformation
mice
monocyte
monocyte-macrophage
Monocytes
Mortality
mouse macrophages
multisystemic
patients
Peripheral blood
peripheral blood monocytes
peritoneal macrophage
peritoneal macrophages
peritonitis
Phagocytic activity
predisposition
Prevalence
rare disease
receptor
recruited
Rendu-Osler-Weber syndrome
response
responsible
show
Signaling
surface antigen
syndrome
target gene
Target genes
TGF-β
TGF-β1
transmembrane protein
triggered
type I
up-regulation
Vascular
vessel wall
was reduced
Weber syndrome
wild-type
[DOI] 10.1371/journal.pgen.1005935 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pgen.1005935 PMC 바로가기 [Article Type] Research Article