SARS-CoV-2 infections in mRNA vaccinated individuals are biased for viruses encoding spike E484K and associated with reduced infectious virus loads that correlate with respiratory antiviral IgG levelsmRNA 백신을 접종한 개인의 SARS-CoV-2 감염은 스파이크 E484K를 인코딩하는 바이러스에 대해 편향되어 있으며 호흡기 항바이러스성 IgG 수준과 상관관계가 있는 감소된 감염성 바이러스 부하와 관련이 있습니다.Article Published on 2022-06-012022-09-11 Journal: Journal of Clinical Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제, [키워드] A significant reduction accompanied Alpha Alpha variant Amino acid Analysis Anti-viral Antiviral association B.1.1.7 B.1.526 BNT162b2 Breakthrough infection breakthrough infections caused Cell culture change Cohort collected COVID-19 cycle threshold dose E484K early phase ELISA examined Genome ICU admission IgG IgG level IgG levels immunization increase in Infectious virus investigated Lineage Moderna molecular Mortality mRNA mRNA-1273 PCR Pfizer-BioNTech positive positive sample Positive test predominant Protein reduce reduced required respiratory respiratory sample Respiratory samples Sample SARS-CoV-2 SARS-CoV-2 IgG antibody SARS-COV-2 infection SARS-CoV-2 positive patient sequenced Sequencing specimen specimens spike Spike protein symptomatic infection symptomatic infections upper respiratory tract vaccinated individual vaccinated individuals vaccination Vaccines variant Viral Viral load viral loads viral variant virus were used whole genome [DOI] 10.1016/j.jcv.2022.105151 PMC 바로가기 [Article Type] Article
Strategies and safety considerations of booster vaccination in COVID-19COVID-19에서 추가 백신 접종의 전략 및 안전 고려 사항Review Published on 2022-06-012022-09-11 Journal: Bosnian Journal of Basic Medical Sciences [Category] Coronavirus, COVID19(2023년), SARS, 변종, [키워드] addition approaches booster booster vaccination breakthrough infections combination vaccine COVID-19 COVID-19 pandemic Diseases Effectiveness Efficacy groups Heterologous homologous Immune escape immunization strategies Immunocompromised persistence priority Protective reducing mortality SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV-2 variant SARS-CoV-2 variants Strategy vaccination Vaccine [DOI] 10.17305/bjbms.2021.7082 PMC 바로가기 [Article Type] Review
The impact of COVID-19 vaccines on the Case Fatality Rate: The importance of monitoring breakthrough infections코로나19 백신이 치사율에 미치는 영향: 돌발 감염 모니터링의 중요성Article Published on 2022-06-012022-09-11 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 치료기술, [키워드] Behavior Breakthrough infection breakthrough infections Case fatality rate CFR Combination COVID-19 COVID-19 infection COVID-19 vaccine death deaths effective Effectiveness effort Fatality rate hypothetical individual individuals Infection pandemic Probability reducing tested Vaccine vaccine effectiveness Vaccines [DOI] 10.1016/j.ijid.2022.03.059 PMC 바로가기 [Article Type] Article
Breakthrough infections after COVID-19 vaccination: Insights, perspectives and challengesResearch article Published on 2022-06-012022-10-05 Journal: Metabolism Open [Category] 변종, [키워드] acquisition administration age antibody Antigen Breakthrough infection breakthrough infections cause Characteristics clinical consequence Comorbidities COVID COVID-19 COVID-19 pandemic determinant Determining dose Effectiveness Host Immune escape immune evasion immune protection Immune status Immunity immunosuppressive drugs incidence Incubation period Infection Long Mortality mucosal nasal neutralizing antibody occur offer omicron Pancoronavirus pathogenicity Perspective platform plethora Public health intervention reduced reducing robust SARS-CoV-2 SARS-CoV-2 variant severe disease Severity of infection shown significantly Spread syndrome Transmissibility Transmission turn vaccinated individuals vaccination Vaccine Vaccines variant variant of concern viral variant virus [DOI] 10.1016/j.metop.2022.100180 [Article Type] Research article
Clinical characterization of COVID-19 breakthrough infections, PhilippinesCOVID-19 돌발 감염의 임상 특성, 필리핀Article Published on 2022-06-012022-09-11 Journal: Journal of Clinical Virology [Category] COVID19(2023년), SARS, 치료기술, [키워드] administration Alpha Asymptomatic Beta booster dose Breakthrough infection breakthrough infections characterized clinical clinically CoronaVac COVID-19 Ct values Delta VOC Evidence HCW HCWs healthcare worker Healthcare workers Inactivated vaccine majority male PCR Philippines risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 transmission sequenced severe cases significantly lower symptomatic viral loads VOCs [DOI] 10.1016/j.jcv.2022.105157 PMC 바로가기 [Article Type] Article
Implication of the emergence of the delta (B.1.617.2) variants on vaccine effectiveness백신 효과에 대한 델타(B.1.617.2) 변이체의 출현의 의미Review Published on 2022-06-012022-09-11 Journal: Infection [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Administered analyzed article assist AstraZeneca B.1.617.2 breakthrough infections concern convalescent patient Convalescent patients COVID-19 COVID-19 vaccine COVID-19 vaccines death Delta delta variant Delta variants determine disease severity effective Effectiveness Efficacy FIVE Hospitalization in vitro in vivo incidence infection with SARS-CoV-2 Meta-analysis Moderna neutralization neutralizing antibody Oxford-AstraZeneca pandemic Pfizer Pfizer-BioNTech reduced reducing reductions in SARS-CoV-2 SARS-CoV-2 pandemic screened searched second dose significant reductions significantly symptomatic infection Transmission vaccinated individual vaccinated individuals vaccination Vaccinations Vaccine Vaccines variant variants [DOI] 10.1007/s15010-022-01759-1 PMC 바로가기 [Article Type] Review
Kinetics and Persistence of the Cellular and Humoral Immune Responses to BNT162b2 mRNA Vaccine in SARS-CoV-2-Naive and -Experienced Subjects: Impact of Booster Dose and Breakthrough InfectionsSARS-CoV-2-나이브 및 -경험 대상자에서 BNT162b2 mRNA 백신에 대한 세포 및 체액 면역 반응의 동역학 및 지속성: 추가 용량 및 돌발 감염의 영향Article Published on 2022-05-312022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] administration age analyzed Anti-nucleocapsid antibodies anti-SARS-CoV-2 anti-spike antibodies anti-spike antibody antibodies antibody association Belgium benefit blood sample Blood samples blood sampling BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine booster booster dose booster doses breakthrough infections cell-mediated immune response cellular cellular and humoral immune response Cellular immune response cellular immune responses collected COVID-19 COVID-19 vaccine DiaSorin dose Elecsy enrolled evaluated greater HCW HCWs Healthcare system healthcare worker Healthcare workers help Human humoral Humoral and cellular immune responses humoral immune response Humoral response IFN-γ IgG immune protection immune response immune responses immunization immunogenicity Impact implication increase in individual level individuals Infection initial Kinetics LIAISON Lymphocytes management mandatory mRNA vaccination mRNA vaccine naïve naïve individuals natural infection Neutralization assay neutralization capacity Neutralizing antibodies pandemic participant Participants Peripheral blood peripheral blood lymphocyte peripheral blood lymphocytes persistence Prevent Prospective Study Qiagen QuantiFERON quantified reduce regimen response SARS- CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination second dose secretion severe COVID-19 significantly higher tested the SARS-CoV-2 triggering understanding university vaccination vaccine dose variant Vero E6 was performed [DOI] 10.3389/fimmu.2022.863554 PMC 바로가기 [Article Type] Article
Vaccination with BNT162b2 and ChAdOx1 nCoV-19 Induces Cross-Reactive Anti-RBD IgG against SARS-CoV-2 Variants including OmicronBNT162b2 및 ChAdOx1 nCoV-19 백신 접종은 Omicron을 포함한 SARS-CoV-2 변이체에 대한 교차 반응성 항-RBD IgG를 유도합니다Article Published on 2022-05-282022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료법, [키워드] adaptive Adaptive immunity age Alpha Alpha variant anti-RBD BNT162b2 booster vaccinations Breakthrough infection breakthrough infections caused ChAdOx1 ChAdOx1 nCoV-19 Cohort contribute Course COVID-19 cross-reactive cross-reactive antibodies cross-reactivity Delta delta variant domain ELISA explain Gamma health-care IgG IgG ELISA IgG level IgG levels Immunity independent independent of individual Infection infection rate lethality magnitude morbidity nucleocapsid nucleocapsid IgG omicron Omicron variants RBD RBD IgG reactivity Receptor-binding domain Receptor-binding domain (RBD) recipient SARS-CoV-2 SARS-CoV-2 testing SARS-CoV-2 variants sera Sex significant increase significantly higher significantly lower Spike protein Spread tested the spike protein university vaccination vaccination rate Vaccine variants variants of concern Vienna VoC VOCs was increased while [DOI] 10.3390/v14061181 PMC 바로가기 [Article Type] Article
A comprehensive evaluation of COVID-19 policies and outcomes in 50 countries and territories50개 국가 및 지역의 COVID-19 정책 및 결과에 대한 종합적인 평가Article Published on 2022-05-252022-09-11 Journal: Scientific Reports [Category] 변종, [키워드] acting Analysis appear Asian breakthrough infections country COVID-19 COVID-19 pandemic develop Effectiveness Efficacy Efficiency Emerging infectious disease Government Health herd immunity hygiene Immunity Indicator Infectious disease Intervention lockdown longitudinal study measure Oceania outcome pandemic Region Vaccine Vaccine development Vaccine hesitancy variant viral strains [DOI] 10.1038/s41598-022-12853-7 PMC 바로가기 [Article Type] Article
SARS-CoV-2-specific immune responses in boosted vaccine recipients with breakthrough infections during the Omicron variant surge오미크론 변이체 급증 동안 돌발 감염이 있는 부스트 백신 수혜자의 SARS-CoV-2 특이적 면역 반응Article Published on 2022-05-232022-09-11 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 ACE2 binding Adaptive immunity allergy analyzed antibody binding booster Breakthrough infection breakthrough infections cellular response Cellular responses COVID-19 ELISpot assay funds healthy Humoral immunity immune response immune responses Infection Infectious disease inhibited Johns Hopkin Johns Hopkins less levels of antibodies levels of antibody median mRNA vaccine National Cancer Institute occur omicron Omicron variant Protein Protein binding receiving recipient recipients robust SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2-specific immune response significantly Spike protein Spike proteins supported T cell T cell response T cells the vaccine vaccinated individual vaccinated individuals Vaccine vaccine strain variant variant spike [DOI] 10.1172/jci.insight.159474 PMC 바로가기 [Article Type] Article