Bronchoalveolar lavage – Page 9 – Communicable Diseases Research

Low-dose Ad26.COV2.S protection against SARS-CoV-2 challenge in rhesus macaques

붉은털 원숭이의 SARS-CoV-2 공격에 대한 저용량 Ad26.COV2.S 보호

Article

Published on 2021-06-242022-09-12
Journal: Cell [Category] MERS, SARS, 비임상, 진단,

Protective efficacy of Ad26.COV2.S against SARS-CoV-2 B.1.351 in macaques

원숭이에서 SARS-CoV-2 B.1.351에 대한 Ad26.COV2.S의 보호 효능

Article

Published on 2021-06-232022-09-10
Journal: Nature [Category] MERS, SARS, 변종, 비임상, 유전자 메커니즘, 진단,

[키워드] Ad26 Ad26.COV2.S Ad26.COV2.S vaccine B.1.1.7 B.1.351 B.1.351 variant binding Bronchoalveolar lavage CAL.20C variants CD4 CD8 Cellular immune response comparable COVID-19 COVID-19 vaccine cross-react demonstrated Efficacy elicit elicited evade expresse Human humoral Humoral and cellular immune responses immune responses implication induce Infection macaque nasal swab nasal swabs Neutralizing antibodies neutralizing antibody P.1 PROTECT Protective provided rhesus macaque rhesus macaques robust SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sequenced South Africa Spike protein stabilized spike protein symptomatic symptomatic COVID-19 T cell T cell response These data Vaccine Vaccines virus virus replication viruses WA1/2020
[DOI] 10.1038/s41586-021-03732-8 PMC 바로가기 [Article Type] Article

Staphylococcus aureus ventilator-associated pneumonia in patients with COVID-19: clinical features and potential inference with lung dysbiosis

Observational Study

Published on 2021-06-072022-10-04
Journal: Critical Care [Category] MERS, 임상,

[키워드] Affect Analysis analyzed Antimicrobial therapy Bacterial Bacterial infection Bronchoalveolar lavage bronchoalveolar lavage sample clinical clinical feature Community controls COVID-19 COVID-19 group COVID-19 patient feature Fold change group hospitalized patient ICU ICU patient Infection initial intensive care IRCCS Italy log lung Lung microbiota mechanical ventilation medical icu microbial community microbiota Mortality multivariable logistic regression non COVID-19 patient Non-COVID-19 non-COVID-19 patient Non-COVID-19 patients Organ failure Patient patients patients with COVID-19 patients without COVID-19 R 2 Result risk Rome SARS-COV-2 infection significantly SOFA Specy Staphylococcus aureus statistically significant difference Streptococcus anginosus study population supplementary material the patient two group Ventilator-associated pneumonia with COVID-19
[DOI] 10.1186/s13054-021-03623-4 PMC 바로가기 [Article Type] Observational Study

SARS-CoV-2 Spike Protein Suppresses ACE2 and Type I Interferon Expression in Primary Cells From Macaque Lung Bronchoalveolar Lavage

Immunology

Published on 2021-06-042022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

High levels of eicosanoids and docosanoids in the lungs of intubated COVID-19 patients

Clinical Trial

Published on 2021-06-012022-10-05
Journal: FASEB journal : official publication of the Federa [Category] SARS, 임상,

[키워드] acute respiratory distress acute respiratory syndrome Analysis Anti-inflammatory arachidonate Aspirin BAL Bronchoalveolar lavage characterized Clinical outcome clinically coronavirus coronavirus disease COVID-19 COVID-19 patient deleterious effect develop docosanoids drug Effect eicosanoid Eicosanoids eoxins Fatty acid healthy control Inflammatory intubated COVID-19 patient leukotriene Lipid lipid mediator lipids LTB lung Lung inflammation mechanical ventilation metabolite modulating Patient Pneumonia pro-inflammatory responsible severe COVID-19 severe COVID-19 patient significantly specialized pro-resolving mediators subset syndrome Tandem mass spectrometry thromboxane to define Treatment was done while
[DOI] 10.1096/fj.202100540R PMC 바로가기 [Article Type] Clinical Trial

A Synthetic Peptide CTL Vaccine Targeting Nucleocapsid Confers Protection from SARS-CoV-2 Challenge in Rhesus Macaques

Article

Published on 2021-05-182022-10-28
Journal: Vaccines [Category] COVID-19,

[키워드] accumulates acute respiratory syndrome Adaptive immune response adjuvant Administered animal model Antibody Response BAL Bronchoalveolar lavage Cell challenge characteristic Chest clinical symptom collected controls coronavirus COVID-19 pandemic CTL CTL epitope downstream analysis Efficacy epitope expression Genome HLA class I immunogenic macaque macaques MHC class I MHC class I peptide microsphere nucleocapsid protein peptide peptide-based vaccine Peripheral blood persistent protection Protective public health recent rhesus macaques SARS-CoV-2 SARS-COV-2 infection sequence variation synthetic synthetic peptide T cell targeting TCID temperature tested the SARS-CoV-2 Transmission unique vaccination Vaccine Vaccines Viral load
[DOI] 10.3390/vaccines9050520 PMC 바로가기 [Article Type] Article

The lower respiratory tract microbiome of critically ill patients with COVID-19

Article

Published on 2021-05-122022-10-04
Journal: Scientific Reports [Category] SARS, 바이오마커, 치료법,

[키워드] 16S rRNA Acinetobacter antibiotic Bacterial bacterial microbiome bacterial superinfection BAL Bronchoalveolar lavage characterized clinical microbiology Clinical outcome Clostridium collected commensal bacteria COVID-19 COVID-19 infection COVID-19 pandemic Critically ill Critically ill patient critically ill patients Enterobacteriaceae Haemophilus influenzae incidence rate Infection Lower respiratory tract lung Microbiome multidrug resistant Non-COVID-19 Pathogens Patient patients patients with pneumonia performed Pneumonia Pseudomona SARS-COV-2 infection secondary bacterial infection significant increase Streptococcus subject with COVID-19
[DOI] 10.1038/s41598-021-89516-6 PMC 바로가기 [Article Type] Article

Association between ACE2 and TMPRSS2 nasopharyngeal expression and COVID-19 respiratory distress

Article

Published on 2021-05-062022-10-04
Journal: Scientific Reports [Category] SARS, 바이오마커,

[키워드] 95% CI ACE2 age applied association Bronchoalveolar lavage Clinical course Cohort conducted Control COVID-19 COVID-19 patient COVID-19 severity defined disease severity distress Epidemiology evaluated expression expression level Factor Gene Expression host cells Increased independent Infectious diseases Logistic regression mechanical ventilation Mild moderate mRNA level nasopharyngeal Nasopharyngeal swab nasopharyngeal swab sample outcome oxygen support Oxygen therapy positively correlated protective effect respiratory outcomes Respiratory tract diseases risk RT-qPCR SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 positive individual Symptom the disease TMPRSS2 TMPRSS2 level Transcription viral infection Virology
[DOI] 10.1038/s41598-021-88944-8 PMC 바로가기 [Article Type] Article

Endothelial eNAMPT amplifies pre-clinical acute lung injury: efficacy of an eNAMPT-neutralising monoclonal antibody

내피 eNAMPT는 전임상 급성 폐 손상을 증폭합니다: eNAMPT 중화 단일클론 항체의 효능

Article

Published on 2021-05-062022-09-11
Journal: The European Respiratory Journal [Category] Fulltext, SARS, 진단, 치료기술, 치료제,

[키워드] abrogate Activation acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome amplify antibody ARDS assays BAL biochemical biologic Biomarker Bronchoalveolar lavage cells Combination coronavirus coronavirus disease demonstrated detect disease effective therapy Efficacy Endothelial cell eosin expression Extracellular genotyping Haematoxylin highlight human lung identify in vitro in vivo increases in Inflammation Inflammatory inflammatory lung injury Innate immunity interleukin-6 knockout mice Ligand lipopolysaccharide lung Lung injury lung tissue lung tissues mAb master regulator mice monoclonal antibody Mortality NAMPT Neutralising Antibodies nicotinamide offer pandemic pathway personalised plasma polyclonal polyclonal antibody polymorphonuclear Predictive probe Protein receptor reduce respiratory respiratory distress severe acute respiratory syndrome Coronavirus severity significantly staining subject syndrome therapeutic target TLR4 Toll-like receptor unmet need was used were used wild-type
[DOI] 10.1183/13993003.02536-2020 PMC 바로가기 [Article Type] Article

Heterogeneity in protocols for bronchoalveolar lavage & sub-genomic RNA evaluation in non-human primate studies of SARS-CoV-2 vaccine candidates’ evaluation

SARS-CoV-2 백신 후보 평가에 대한 비인간 영장류 연구에서 기관지폐포 세척 및 하위 게놈 RNA 평가를 위한 프로토콜의 이질성

Comment

Published on 2021-05-012022-09-11
Journal: The Indian journal of medical research [Category] SARS, 유전자 메커니즘,

[키워드] Bronchoalveolar lavage candidate non-human primate protocol RNA SARS-CoV-2 vaccine
[DOI] 10.4103/ijmr.IJMR_4925_20 PMC 바로가기 [Article Type] Comment