In Silico Evaluation of Sesquiterpenes and Benzoxazinoids Phytotoxins against Mpro, RNA Replicase and Spike Protein of SARS-CoV-2 by Molecular Dynamics. Inspired by NatureArticle Published on 2022-08-292022-11-15 Journal: Toxins [Category] SARS, 치료제, [키워드] active against added addition Analysis antiviral activities benzoxazinoid calculated candidate complex complexes Compound COVID-19 derivative derivatives described docking docking score Dynamics ENhance evaluated fluctuation generate Hydrogen bond in silico interactions kinetic M pro molecular molecular docking molecular dynamics MPro Nature Phytotoxin protease Protein protein-ligand replicase RMSD RNA SARS-CoV-2 selected Sesquiterpene shown spike spike glycoprotein Spike protein stability tested the spike protein virus were assessed [DOI] 10.3390/toxins14090599 PMC 바로가기
Surface charge changes in spike RBD mutations of SARS-CoV-2 and its variant strains alter the virus evasiveness via HSPGs: A review and mechanistic hypothesisArticle Published on 2022-08-242022-11-16 Journal: Frontiers in Public Health [Category] SARS, 변종, 유전자 메커니즘, [키워드] Affect Alter antibodies antibody binding binding affinity calculated cells change changes changes in Characteristics complexes contagious COVID-19 pandemic distribution docking domain drug design electrostatic electrostatic interaction ENhance entry of SARS-CoV-2 epitope hACE2 HSPGs human Angiotensin-converting enzyme hypothese Hypothesis immune evasion Invasion involved molecular mechanism mutant Mutation mutations neutralizing antibody occurred omicron pathophysiological Point mutation positive Protein Proteoglycan RBD RBD mutation RBD mutations residue S protein S trimer SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 variants strain surface the RBD Therapies Vaccine development variant variant strain viral fitness viral infectivity virulence virus virus receptor [DOI] 10.3389/fpubh.2022.952916 PMC 바로가기
Neutralizing Antibody Response to Pseudotype Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Differs Between mRNA-1273 and BNT162b2 Coronavirus Disease 2019 (COVID-19) Vaccines and by History of SARS-CoV-2 Infection유사형 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2)에 대한 중화 항체 반응은 mRNA-1273과 BNT162b2 코로나바이러스 질병 2019(COVID-19) 백신과 SARS-CoV-2 감염의 역사에 따라 다릅니다.Article Published on 2022-08-242022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, [키워드] 19 2 95% confidence interval Antibody titer BNT162b2 BNT162b2 vaccine calculated coronavirus 2 CoV COVID COVID-19 Dilution dose geometric mean GMT GMTs highest history increase Infection inhibitory linear mixed-effects models mRNA mRNA COVID-19 vaccine mRNA vaccine mRNA-1273 mRNA-1273 vaccine NAb Neutralizing antibodies neutralizing antibody participant participants with SARS-CoV-2 prospective cohort pseudotype virus receiving respiratory response SARS SARS-CoV-2 SARS-COV-2 infection sera single dose Symptoms T Test tested uninfected participant uninfected participants vaccination Vaccine vaccine dose was collected [DOI] 10.1093/cid/ciab1038 PMC 바로가기 [Article Type] Article
High Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Household Transmission Rates Detected by Dense Saliva Sampling고밀도 타액 샘플링으로 감지된 고중증급성호흡기증후군 코로나바이러스 2(SARS-CoV-2) 가구 전파율Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Analysis attack rate calculated capillary blood capillary blood samples children collected coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 Dense enrolled highest household household transmission Households independent index case individuals infection control investigated majority measure nasopharyngeal swabs not affected NPs oropharyngeal swab oropharyngeal swabs pandemic phylogenetic analyses polymerase chain polymerase chain reaction positive Rate Real-time monitoring repeated reported Research respiratory Saliva saliva sample saliva samples sampling SAR SARS-CoV-2 SARS-CoV-2 transmission secondary attack rate secondary case secondary cases serology serum serum sample severe acute respiratory syndrome Coronavirus study inclusion suggested Swab tested understanding vaccination was performed Whole genome sequencing [DOI] 10.1093/cid/ciac261 PMC 바로가기 [Article Type] Article
Rapid Spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Omicron Subvariant BA.2 in a Single-Source Community Outbreak단일 출처 커뮤니티에서 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 오미크론 하위 변종 BA.2의 급속한 확산Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, [키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed Asia BA.2 sublineage calculated Cluster Community community outbreak coronavirus coronavirus 2 COVID-19 doubling epidemiological epidemiologically Europe genomic Genomic analysis highlight Hong Kong housing estate. individual information involved lockdown measure Mutation omicron Omicron variant outbreak Oxford Nanopore MinION Patient performed Phylogenetic analysis Rapid respiratory SARS-CoV-2 SARS-CoV-2 Omicron variant sequence Sequencing severe acute respiratory syndrome Coronavirus Surveillance Transmissibility unique variant Viral genome sequencing was performed whole-genome sequencing [DOI] 10.1093/cid/ciac203 PMC 바로가기 [Article Type] Article
Real-world effectiveness of early molnupiravir or nirmatrelvir–ritonavir in hospitalised patients with COVID-19 without supplemental oxygen requirement on admission during Hong Kong’s omicron BA.2 wave: a retrospective cohort studyResearch article Published on 2022-08-242022-10-05 Journal: The Lancet. Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] 1:1 Abstract Admission all-cause mortality analysed Antiviral Antiviral treatment authority calculated Chinese clinical benefit contraindication Control controls COVID-19 COVID-19 diagnosis Cox regression models Cycle threshold value Department diagnosis of SARS-CoV-2 Disease progression Effectiveness eligible evaluate event exclusion finding Follow-up for inclusion funding hazard ratio Hong Kong hospital hospitalised hospitalised patient HRs ICU admission IMV incidence rate Infection intensive care Invasive mechanical ventilation lower risk material Mild-to-moderate molnupiravir need for oxygen oral outcome outcomes Oxygen therapy pandemic Patient patients Primary outcome recipient Region registry renal required retrospective cohort retrospective cohort study RT-PCR SARS-CoV-2 SARS-COV-2 infection secondary outcome severe liver impairment Significant significantly shorter study period supplemental oxygen Support symptom onset therapy time translation viral burden virological outcome were excluded with COVID-19 [DOI] 10.1016/S1473-3099(22)00507-2 [Article Type] Research article
Remdesivir Plus Dexamethasone Versus Dexamethasone Alone for the Treatment of Coronavirus Disease 2019 (COVID-19) Patients Requiring Supplemental O2 Therapy: A Prospective Controlled Nonrandomized Study코로나바이러스 질병 2019(COVID-19) 환자 치료를 위한 렘데시비르 플러스 덱사메타손 대 덱사메타손 단독 요법: 보충 O2 요법이 필요한 환자: 전향적 통제된 비무작위 연구Controlled Clinical Trial Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 임상, 치료제, [키워드] 30-Day mortality Antiviral baseline calculated clinical outcomes cohorts Combination Controlled coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient CRP D-dimer Dexamethasone drug effective Endpoint enrolled evaluate evaluated faster fibrinogen FiO2 group groups Hospitalization IMPROVE independent Inflammatory inflammatory markers Kaplan-Meier Kaplan-Meier curve Kaplan-Meier curves laboratory characteristics log-rank test median Mortality neutrophil neutrophil/lymphocyte ratio no differences occurred primary endpoint primary endpoints Prospective reducing mortality reduction in reduction in mortality Remdesivir Respiratory failure Respiratory function Sample size SARS-CoV-2 clearance secondary Secondary endpoints shown significant difference significant differences survival the log-rank test therapy treat Treatment viral clearance were used [DOI] 10.1093/cid/ciac014 PMC 바로가기 [Article Type] Controlled Clinical Trial
Investigation of a Severe Acute Respiratory Syndrome Coronavirus 2 Delta (B.1.617.2) Variant Outbreak Among Residents of a Skilled Nursing Facility and Vaccine Effectiveness Analysis: Maricopa County, Arizona, June-July 2021중증 급성 호흡기 증후군 코로나바이러스 2 델타(B.1.617.2) 전문 요양 시설 거주자의 변종 발병 및 백신 효과 분석: 2021년 6월-7월 애리조나주 마리코파 카운티에 대한 조사Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, [키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjusted affected assistance B.1.617.2 calculated clinical outcomes complex coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 Coverage COVID-19 Cox proportional hazard Cox proportional hazards models Delta delta variant demographics Department died dose Effectiveness electronic medical record estimate facility health department highest Hospitalized Immunocompromised inclusion criteria infection control investigation Local local public health male median age Medical conditions Messenger RNA mRNA mRNA vaccine Nursing outbreak Outbreaks outcomes positive Public public health rehabilitation resident respiratory SARS-CoV-2 SARS-CoV-2 test severe acute respiratory syndrome Coronavirus skilled nursing facility symptomatic infection tested unique vaccination vaccination rate Vaccination Status Vaccine white [DOI] 10.1093/cid/ciac240 PMC 바로가기 [Article Type] Article
Genetic predispositions to psychiatric disorders and the risk of COVID-19정신 질환에 대한 유전적 소인과 COVID-19의 위험Article Published on 2022-08-232022-09-11 Journal: BMC Medicine [Category] 변종, [키워드] 95% CI 95% confidence interval adjusted odds ratio analyses Analysis Anxiety ascertainment association calculated coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 case COVID-19 cases COVID-19 pandemic dataset death death records Depression disorder disorders examined Factor Genetic genetic factors Genetic predisposition genetic risk Genetic variant Genome-wide association study GWAS GWAS summary statistics hospital Hospitalization increased risk individual Logistic regression participant performed phenotype phenotypic predisposition PRS Psychiatric psychiatric disorder Psychiatric disorders Psychiatric disorders. psychotic disorder Public Health England Randomly repeated risk risk of COVID-19 selected severe cases severe COVID-19 stress-related disorders study population Surveillance UK biobank vulnerable population were used [DOI] 10.1186/s12916-022-02520-z PMC 바로가기 [Article Type] Article
Predictive values of time-dense SARS-CoV-2 wastewater analysis in university campus buildings대학 캠퍼스 건물에서 시간 밀도가 높은 SARS-CoV-2 폐수 분석의 예측 값Article Published on 2022-08-202022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 치료기술, [키워드] Analysis approach Asymptomatic surveillance calculated carried clinical Clinical case Concordance conducted COVID-19 case COVID-19 cases criteria data sets detect Duke evaluated Frequency highest Hope incidence indicated Infection instance Intervention majority Negative predictive value positive positive PCR Positive predictive value PPV Predictive Predictive value residence Residence hall. SARS-CoV-2 SARS-CoV-2 surveillance selected Surveillance Transmission university wastewater while [DOI] 10.1016/j.scitotenv.2022.155401 PMC 바로가기 [Article Type] Article