Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19MIS-C의 심층 면역 프로파일링은 성인 및 소아 COVID-19에 비해 현저하지만 일시적인 면역 활성화를 보여줍니다Research Articles Published on 2021-03-022022-09-12 Journal: Science Immunology [Category] 진단, [키워드] Activation acute respiratory distress acute respiratory distress syndrome Admission adult disease Adults analyzed antibody ARDS CD8+ T cell CD8+ T cells characterized children Clinical improvement Complication correlated COVID-19 COVID-19 patient CX3CR1 death deep defined disease elevated feature Frequency Hospitalization Hospitalized illness immune immune activation immune profiling immune response immune responses immune signature lymphocyte lymphopenia medication MIS-C Patient pediatric Pediatric patient Peripheral blood respiratory distress robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike-specific severely ill adults Shock specific antibodies subset sustained syndrome T cell T cell activation T cells trajectory Vascular Vasoactive [DOI] 10.1126/sciimmunol.abf7570 PMC 바로가기 [Article Type] Research Articles
Induction of SARS-CoV-2 Protein S-Specific CD8+ T Cells in the Lungs of gp96-Ig-S Vaccinated Micegp96-Ig-S 백신 접종 마우스의 폐에서 SARS-CoV-2 단백질 S-특이적 CD8+ T 세포의 유도Immunology Published on 2021-01-262022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] airways Allogeneic Antigen CD4+ CD8+ CD8+ T cell CD8+ T cells Cell Cell-mediated immune responses cellular Cellular immune response chaperone COVID-19 deaths expressing full-length protein generate glycoprotein glycoprotein 96 Heat shock heat shock protein humans immune system IMPROVE induce induction leukocyte lung Lungs measure observation Protein protein S public health response robust SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 protein SARS-CoV-2 protein S secreted Spread stimulate Support the vaccine transgenic mice translational Vaccine vaccine candidate vaccine platform [DOI] 10.3389/fimmu.2020.602254 PMC 바로가기 [Article Type] Immunology
Time-course analysis reveals that corticosteroids resuscitate diminished CD8+ T cells in COVID-19: a retrospective cohort studyResearch Article Published on 2021-01-112022-10-28 Journal: Annals of Medicine [Category] COVID-19, SARS, [키워드] accelerated Analysis association CD8+ T cell change Coagulation coronavirus disease correlated Corticosteroid Corticosteroids COVID-19 Critical case Critically ill patient D-dimer diagnosed with COVID-19 dose Generalized help Immunity Inflammation involved low-dose corticosteroid Methylprednisolone moderate Neutrophil to lymphocyte ratio NLR objective parameter participant Patient per day Result retrospective cohort study reveal rising severity significantly increased Treatment was performed [DOI] 10.1080/07853890.2020.1851394 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 Viral RNA Shedding for More Than 87 Days in an Individual With an Impaired CD8+ T Cell ResponseCD8+ T 세포 반응이 손상된 개인에서 87일 이상 동안 SARS-CoV-2 바이러스 RNA 방출Observational Study Published on 2021-01-082022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 임상, 진단, 치료기술, [키워드] airway Antibody titer Antibody titers case subject CD4+ T cell CD8+ CD8+ T cell cellular immunity circulating Cohort COVID-19 Day detectable exhibited expected first positive Impaired in some individual individuals with COVID-19 Infection Neutralizing antibody response neutralizing antibody responses occur one individual plasma neutralization activity positive Prolonged Protein Re-infection response RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral RNA severe COVID-19 shedding subject subjects symptom onset T cell T cell responses T cells tested upper airway Viral Viral RNA Viral RNA shedding [DOI] 10.3389/fimmu.2020.618402 PMC 바로가기 [Article Type] Observational Study
SARS-CoV-2-reactive interferon-γ-producing CD8+ T cells in patients hospitalized with coronavirus disease 2019코로나바이러스 질병 2019로 입원한 환자의 SARS-CoV-2 반응성 인터페론-γ 생성 CD8+ T 세포Article Published on 2021-01-012022-09-12 Journal: Journal of medical virology [Category] 진단, [키워드] acute respiratory syndrome Amino acid antibody antigenic blood cell count CD4+ CD8+ CD8+ T cell CD8+ T cells CD8+ T-cell Clinical course comparable coronavirus coronavirus disease correlation COVID-19 detectable detection rate determine displaying entire sequence expressing flow-cytometry form Frequency glycoprotein hospitalized patient IFN-γ Immunoglobulin inflammatory biomarkers information intensive care interferon-γ intracellular cytokine staining M protein median microbiologically N-terminal no correlation overlapping Patient patients hospitalized patients with moderate peptide producing prognostic quantitation responses SARS-CoV-2 SARS-COV-2 infection sequence spike subset T-cell T-cell immune response T-cell immunity tested the disease the SARS-CoV-2 were used [DOI] 10.1002/jmv.26213 PMC 바로가기 [Article Type] Article
Interferon-α2b Treatment for COVID-19 Is Associated with Improvements in Lung AbnormalitiesCOVID-19에 대한 인터페론-α2b 치료는 폐 이상 개선과 관련이 있습니다Article Published on 2020-12-302022-09-10 Journal: Viruses [Category] MERS, SARS, 바이오마커, 치료제, [키워드] accelerated acute respiratory syndrome acute respiratory syndrome coronavirus age albumin Analysis ARB Arbidol C-reactive protein cause CD8+ T cell CD8+ T cells circulating clinical clinical study coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CRP CT images death determine IFN treatment IFN-α2b IL-6 IL-6 levels immune parameter improvement include independent of individual Infection Inflammatory biomarker inflammatory biomarkers Inhaled interferon limit lung abnormalities lung abnormality Lung disease Moderate COVID-19 Necrosis organ Platelets predictor provided reduction in reported respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity study cohort T cell T cells the strongest therapeutic intervention treated Treatment Tumor tumor necrosis tumor necrosis factor upper airway upper airways Viral viral clearance with COVID-19 worsening [DOI] 10.3390/v13010044 PMC 바로가기 [Article Type] Article
Safety and immunogenicity of INO-4800 DNA vaccine against SARS-CoV-2: A preliminary report of an open-label, Phase 1 clinical trialResearch article Published on 2020-12-242022-10-05 Journal: EClinicalMedicine [Category] Coronavirus, 비임상, [키워드] administration adverse event Antigen binding binding antibody CD8+ T cell cellular cellular immune responses CEPI clinical trial Coalition COVID-19 Cytometry demonstrated described DNA vaccine ELISA ELISpot assay evaluated finding Flow Frequency full length funding geometric geometric mean titer Grade 1 groups humoral humoral immune response IC50 IL-4 immunogenic increase in Innovation INO-4800 median age men neutralizing antibody Open-label participant Participants PBMC Phase 1 preliminary report PRNT receiving reported response Safety SARS-CoV-2 second dose Serious Adverse Event seroconverted SFU subject T cell response the median TNF-α Tolerability Trial two group urgency Vaccine [DOI] 10.1016/j.eclinm.2020.100689 [Article Type] Research article
Harnessing Cellular Immunity for Vaccination against Respiratory VirusesReview Published on 2020-12-212022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] activate acute respiratory disease acute respiratory syndrome approach Aside B cell response candidate CD4+ CD8+ T cell Cellular immune response cellular immunity Clinical sign Coronavirus-2 Coronaviruses Critical detrimental Efficacy and safety examined group Health humoral immune response illness immunocompromised individuals immunopathology Infants Infection Influenza long-lasting métapneumovirus Mild morbidity Mortality Nanoparticles neutralizing antibody Patient Pneumonia Protein Research respiratory Respiratory illness respiratory syncytial virus respiratory viral respiratory viral infections respiratory viruses response rhinovirus RNA RNA vaccines robust RSV SARS-CoV-2 severe disease subunits tested These viruses upper respiratory vaccination Vaccine vaccine candidate vaccine candidates viral infection virus Virus-like particle virus-like particles viruses VLPs [DOI] 10.3390/vaccines8040783 PMC 바로가기 [Article Type] Review
mRNA induced expression of human angiotensin-converting enzyme 2 in mice for the study of the adaptive immune response to severe acute respiratory syndrome coronavirus 2중증 급성 호흡기 증후군 코로나바이러스 2에 대한 적응 면역 반응 연구를 위해 쥐에서 mRNA 유도 인간 안지오텐신 전환 효소 2 발현Research Article Published on 2020-12-162022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, MERS, SARS, 치료법, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal model Antigen Antiviral Author caused CD4+ CD4+ T cell CD8+ CD8+ T cell cells cloned coronavirus Critical demonstrated Efficacy entry of SARS-CoV-2 Epitopes expressed expression functional hACE2 hACE2 receptor human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 human coronavirus humans immune response in vivo induce Infection information interferon receptor Laboratory lack membrane Membrane proteins memory mice mRNA mRNA expression mRNA transfection mRNA-based murine murine model murine models nucleocapsid pandemic peptide peptide epitope peptides preserved provided receptor Replication required respiratory response SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 pathogenesis Secondary infection severe acute respiratory syndrome Coronavirus Spike proteins strain T cell T cell epitope T cell epitopes T cell response T cells this system type 1 interferon unique Vaccine vaccine efficacy Vaccines virus [DOI] 10.1371/journal.ppat.1009163 PMC 바로가기 [Article Type] Research Article
Maturation of T and B Lymphocytes in the Assessment of the Immune Status in COVID-19 PatientsArticle Published on 2020-12-052022-10-31 Journal: Cells [Category] COVID-19, MERS, SARS, [키워드] assessment B cells maturation CD4+ CD4+ cell CD4+ cells CD4+ T cells CD8+ T cell Cell central memory central memory CD4+ change chest X-ray COVID-19 COVID-19 patient COVID-19 patients effector CD8+ cells evaluate flow cytometry healthy control immunological profile interstitial lesion leukocyte lymphocyte maturation naïve novel coronavirus disease Patient patients patients with COVID-19 plasmablast plasmablasts proportion selected significantly higher status study group T cell T cells maturation T lymphocyte Topic was performed X-ray [DOI] 10.3390/cells9122615 PMC 바로가기 [Article Type] Article