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[키워드] Accuracy ACE2 ACE2 orthologs ACE2 variant ACE2 variants acute respiratory syndrome acute respiratory syndrome coronavirus affinity-enhancing mutation affinity-enhancing mutations Amino acid amino acid residue amino acids antiviral therapeutics atomic level benefit blueprint chicken complement computational modeling Computational study confirmed case confirmed cases Contact coronavirus country Cross-species transmission develop disrupt Drug development experiments explain geographical distribution global pandemic help highlight host cell host cell membrane host receptor Human humans in some infect Infection infection cycle infection process insight Interaction investigated key amino acid key amino acids key polar Like mice molecular feature non-conservative mutation non-conservative mutations not applicable other coronaviruses pandemic predict protein interactions provide question receptor protein respiratory responsible risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein several ACE2 amino acid residues several ACE2 ortholog several ACE2 orthologs severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 species Spike protein structural framework Structural properties structural property susceptible the SARS-CoV-2 therapeutic purposes Therapeutics thought three-dimensional structure Transmission transmitted Viral viral infection viral infections Viral protein viral spike protein viral-host protein interaction viral-host protein interactions viruses widespread wild animals
[DOI] 10.1371/journal.pcbi.1008449 PMC 바로가기 [Article Type] Research Article