A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection
RBD를 표적으로 하는 합성 나노바디는 SARS-CoV-2 감염으로부터 햄스터를 보호합니다
Article
[키워드] ACE2 protein
animal model
animal models
antibody
bind
binding
Bioavailability
biochemical
candidate
Candidates
causative agent
Clinical sign
Clinical signs
COVID-19
domain
feature
form
hamster
hamsters
high affinity
high stability
host cell
in vitro
inhibited
Interaction
Live virus
llama
mechanism
medical intervention
nanobodies
nanobody
neutralization activity
Neutralizing
Neutralizing antibodies
offer
outbreak
PROTECT
pseudoviruses
RBD
RBD-ACE2
Receptor-binding domain
reduce
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2 pseudovirus
SARS-CoV-2 pseudoviruses
single dose
storage
structure-based design
sybodies
sybody
synthetic nanobodies
synthetic nanobody
therapeutic
therapeutic activity
Viral RNA
viral RNA load
virus
X-ray crystallography
[DOI] 10.1038/s41467-021-24905-z PMC 바로가기 [Article Type] Article
[DOI] 10.1038/s41467-021-24905-z PMC 바로가기 [Article Type] Article