Kinetics of Nucleo- and Spike Protein-Specific Immunoglobulin G and of Virus-Neutralizing Antibodies after SARS-CoV-2 InfectionArticle Published on 2020-10-132022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] Accuracy acute respiratory syndrome Antibody test calculated collected convalescent sera coronavirus COVID-19 Diagnosis diagnostic diagnostics eight exhibited FIVE Follow-up Humoral immunity IgG IgG response immunoassay Immunoblots Immunoglobulin Immunoglobulin G individual Infection Kinetics neutralization Neutralizing antibodies neutralizing antibody Patient patients PCR PCR-confirmed Protein ranged SARS-CoV-2 SARS-COV-2 infection selected sensitivities sera Specificities specificity spike sustained test performance titer decrease virus-neutralizing were recorded [DOI] 10.3390/microorganisms8101572 PMC 바로가기 [Article Type] Article
A Novel In-Cell ELISA Assay Allows Rapid and Automated Quantification of SARS-CoV-2 to Analyze Neutralizing Antibodies and Antiviral Compounds새로운 세포 내 ELISA 분석을 통해 SARS-CoV-2의 신속하고 자동화된 정량화를 통해 중화 항체 및 항바이러스 화합물 분석Immunology Published on 2020-10-092022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition antibodies Antigen antiviral agent Antiviral agents antiviral drug antiviral drugs antiviral interferon antiviral interferons Applying approach automated caused Cell culture cell lines Compound convalescent plasma convalescent sera coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 diagnostics dose doses Duration of infection Efficacy ELISA ELISAs equipment evaluate human sera Immunity immunity certificates infected cells interferon interferons NAb NAbs neutralization Neutralization assay neutralization test neutralization tests Neutralizing novel optimization other coronaviruses parameter plaque reduction neutralization PRNT quantification Quantitative raised Rapid reagent reagents reduced respiratory SARS-CoV-2 SARS-CoV-2 neutralization SARS-CoV-2 PRNT SARS-CoV-2-infected cell SARS-CoV-2-infected cells serological severe acute respiratory syndrome Coronavirus the SARS-CoV-2 time-consuming Vaccine vaccine candidate virus virus infection virus-neutralizing antibodies virus-neutralizing antibody virus-specific antibodies viruses [DOI] 10.3389/fimmu.2020.573526 PMC 바로가기 [Article Type] Immunology
Functional mapping of B-cell linear epitopes of SARS-CoV-2 in COVID-19 convalescent populationResearch Article Published on 2020-09-172022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, SARS, [키워드] antibody B-cell blocked caused composed convalescent convalescent sera COVID-19 Diagnosis Dilution dominant epitope Efficacy elicit elicited epitope FIVE indicated Interaction linear epitope membrane mortalities neutralization activity Neutralizing neutralizing antibody Non-COVID-19 overlapped pandemic peptide performed Proteins SARS-CoV-2 SARS-CoV-2 vaccine sera specific antigen the vaccine Vaccine vaccine candidate viral infection [DOI] 10.1080/22221751.2020.1815591 PMC 바로가기 [Article Type] Research Article
A comprehensive, longitudinal analysis of humoral responses specific to four recombinant antigens of SARS-CoV-2 in severe and non-severe COVID-19 patients중증 및 비중증 COVID-19 환자에서 SARS-CoV-2의 4가지 재조합 항원에 대한 체액 반응에 대한 포괄적이고 종단적인 분석Research Article Published on 2020-09-102022-08-13 Journal: PLoS Pathogens [Category] Biology and Life Sciences, COVID-19, SARS, [키워드] accompanied adaptive affected analyzed antibody Antibody Response Antibody responses Antigen antigens approved cause Combined Community convalescent phase convalescent sera coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patient COVID-19 patients disease onset Disease progression ECD ectodomain effective effective drug effective drugs Evidence Follow-up global pandemic hospital discharge Humoral response humoral responses IgA IgA response IgG responses IgM and IgG indicated information Intervention longitudinal analysis magnitude Most patient Most patients neutralization activities neutralization activity neutralization potency neutralizing activities Neutralizing activity non-severe patients nucleoprotein pandemic Patient Prevent profiles progression provide RBD Receptor binding domain reduction remained reported response S1 protein SARS-CoV-2 sensitivity Serological assay Serological testing serum Seven severe COVID-19 patient severe patients shown significantly specificity Spike protein the disease the SARS-CoV-2 the spike protein treat Treatment understanding Vaccine Vaccine design virus [DOI] 10.1371/journal.ppat.1008796 PMC 바로가기 [Article Type] Research Article
Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in miceArticle Published on 2020-07-092022-10-29 Journal: Nature Communications [Category] COVID-19, SARS, [키워드] ADE Antibody titer Antibody-dependent enhancement Biomaterials - vaccines Cellular responses characterized comparable convalescent sera develop dose-dependent global pandemic IFN IgG immunization induce LNP magnitude mice Molecular medicine neutralization Neutralizing antibody titer observé patients pseudo-virus Recovered COVID-19 patients RNA RNA vaccines robust SARS-CoV-2 SARS-CoV-2 peptides sera Spike protein Spread the SARS-CoV-2 the vaccine translation Vaccine vaccine candidate wild-type virus [DOI] 10.1038/s41467-020-17409-9 PMC 바로가기 [Article Type] Article
Dynamic surveillance of SARS-CoV-2 shedding and neutralizing antibody in children with COVID-19Letter Published on 2020-06-092022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, SARS, [키워드] acute phase acute respiratory syndrome caused Characteristics children children with COVID-19 China convalescent phase convalescent sera coronavirus Coronavirus disease 2019 COVID-19 Diagnosis diagnosis of COVID-19 discharge dynamic eight information investigated median NAb Nasopharyngeal swab nasopharyngeal swabs neutralizing antibody nine oropharyngeal swab oropharyngeal swabs Patient produced SARS-CoV-2 SARS-CoV-2 vaccine serum specimen Spread Stool Surveillance Urine viral shedding [DOI] 10.1080/22221751.2020.1772677 PMC 바로가기 [Article Type] Letter
Antibody Dependent Enhancement Due to Original Antigenic Sin and the Development of SARSImmunology Published on 2020-06-052022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] absence ADE antibody antibody dependent enhancement (ADE) Antigen antigenic antigenic sin arise cause children Clinical course Clinical sign contrary convalescent sera coronavirus coronavirus Coronavirus infection coronavirus strain Course COVID-19 cross-reactive cross-reactive antibody cross-reactivity Dependent described development ENhance enhancement expected Human IgG immune response immune system Infection infection with SARS-CoV-2 infections memory new virus original pandemic Patient patients progression protecting IgG Protective question Receptor binding protein related virus respiratory tract infection respond SARS-CoV-2 Sin Spike protein the SARS-CoV-2 treating COVID-19 patient viral clearance viral infections virus [DOI] 10.3389/fimmu.2020.01120 PMC 바로가기 [Article Type] Immunology
Antibodies to coronaviruses are higher in older compared with younger adults and binding antibodies are more sensitive than neutralizing antibodies in identifying coronavirus‐associated illnessesResearch Article Published on 2020-03-032022-11-01 Journal: Journal of medical virology [Category] Coronavirus, Fulltext, MERS, [키워드] Adults antibodies antibody assessment binding binding antibody cardiopulmonary disease cause contribute convalescent sera coronavirus coronavirus correlation evaluated healthy Human Humoral immunity illness illnesses Immunity immunosorbent increase increases in Infection infections monitoring neutralization Neutralization assay Neutralizing antibodies neutralizing antibody occurred Older polymerase chain Prospective Study Protective Reinfection repeated Respiratory illness respiratory illness secretion stimulated strain Strains subject subjects susceptibility virus Virus shedding were measured [DOI] 10.1002/jmv.25715 PMC 바로가기 [Article Type] Research Article
Development and Validation of a S1 Protein-Based ELISA for the Specific Detection of Antibodies against Equine CoronavirusArticle Published on 2019-11-302022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Accuracy analysis characteristic convalescent sera coronavirus cut-off value demonstrated detection determine development diagnostic ELISA enteric disease enzyme-linked immunosorbent Equine coronavirus Europe France Infection involved Japan outbreak performed Population populations positive reported ROC S1 protein sera Seroconversion Seroprevalence serum sample Specific specificity spike S1 protein Support USA validation Virus neutralization [DOI] 10.3390/v11121109 PMC 바로가기 [Article Type] Article