CETSA MS Profiling for a Comparative Assessment of FDA-Approved Antivirals Repurposed for COVID-19 Therapy Identifies TRIP13 as a Remdesivir Off-TargetArticle Published on 2020-11-182022-10-04 Journal: SLAS discovery : advancing life sciences R & D [Category] 신약개발, 치료제, [키워드] Antiviral compound antiviral drug antivirals assessment binding cells cellular CETSA MS changes in Clinical effect Comparative complex Compound contribute coronavirus disease COVID-19 COVID-19 therapy Effect Efficacy emerging disease example Host host cell induce Interaction molecular target physiological Profiling Protein Protein target proteome Remdesivir reuse small molecule target target engagement targets Therapies thermal stability TRIP13 turn Viral protein virus [DOI] 10.1177/2472555220973597 PMC 바로가기 [Article Type] Article
Repurposing Immunomodulatory Therapies against Coronavirus Disease 2019 (COVID-19) in the Era of Cardiac Vigilance: A Systematic ReviewReview Published on 2020-09-112022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] animal models Anti-inflammatory benefit building Cancer Cancer therapy cardiac cardio-oncology clinical outcomes clinical trial coronavirus 2019 (COVID-19) coronavirus disease COVID-19 COVID-19 infection COVID-19 therapy Cytokine release syndrome decrease drug Efficacy effort Evidence Human hyper-inflammatory phase identify Immunomodulatory therapies Immunotherapy Inflammation Intervention low dose dexamethasone mechanism Microvascular thrombosis outcomes pandemic physician potential therapy proliferation recovery Repurposed drug repurposing review safety profile screened therapeutic therapy Trial vascular permeability Volume [DOI] 10.3390/jcm9092935 PMC 바로가기 [Article Type] Review
Current Status of COVID-19 Therapies and Drug Repositioning ApplicationsReview Published on 2020-06-202022-10-04 Journal: iScience [Category] 신약개발, 치료제, [키워드] addition application approach approved drug clinical trial computational approach concerning coronavirus COVID-19 COVID-19 therapy current drug Drug discovery effort example facilitate Health Health Sciences highlight illness in silico indications information Medicine produced repositioning SARS-CoV-2 Spread status target treat Treatment urgency [DOI] 10.1016/j.isci.2020.101303 PMC 바로가기 [Article Type] Review
Deubiquitinating Enzymes in Coronaviruses and Possible Therapeutic Opportunities for COVID-19Review Published on 2020-05-152022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] activity acute respiratory syndrome affecting antiviral therapy clinical trial Consensus coronavirus coronavirus disease coronavirus epidemics Coronavirus infections COVID-19 COVID-19 therapy cysteine proteases drugs DUBs enzyme evaluated expressed function host cell host’s immune response immune response IMPROVE in vitro Infection inhibitor innate immune response intrinsic ISG15 majority Modification multifunctional opportunity outbreak pandemic Papain-like protease Pathogenesis pathway patient survival Pleiotropic effects PLP PLP inhibitors polypeptides Prevent protease Protein Proteins regulate Regulatory required responsible SARS SARS-CoV2 second Spread stability target proteins therapeutic strategy treat Treatment ubiquitin Viral pneumonia viral replication [DOI] 10.3390/ijms21103492 PMC 바로가기 [Article Type] Review