Specificity and Mechanism of Coronavirus, Rotavirus, and Mammalian Two-Histidine Phosphoesterases That Antagonize Antiviral Innate ImmunityResearch Article Published on 2021-08-102022-10-29 Journal: mBio [Category] COVID-19, [키워드] 2-5A activate Activation activities AKAP7 Antiviral antiviral effects antiviral response cellular cleave cleaved coronavirus CoVs degrade enzyme Enzymes evolutionary relationship IFN Innate Innate immunity interferons investigated limit mammalian MERS-CoV MHV Middle East mouse CoV mouse hepatitis virus NS2 NS4b OAS phosphate producing Protein Regulation respiratory syndrome coronavirus RNA RNase RNase L rotavirus shown the interferon tissue damage trimer two-histidine phosphoesterase viral escape viral infection while [DOI] 10.1128/mBio.01781-21 PMC 바로가기 [Article Type] Research Article
Polyphenols Could Prevent SARS-CoV-2 Infection by Modulating the Expression of miRNAs in the Host CellsPerspectives Published on 2021-08-012022-10-28 Journal: Aging and Disease [Category] COVID-19, [키워드] alveolar Analysis Antiviral antiviral properties antiviral property Apoptosis Cell cellular cellular miRNA Complication COVID-19 CoVs cytoplasm cytosol Defense degrade Endothelial cell endothelial cells expression Host host cell host miRNAs Hypothesis identify involved lung microRNA miRNA miRNAs modulate modulated modulating nutriepigenomic performed polyphenol polyphenols Prevent prevention Regulation RNA SARS-CoV-2 SARS-CoV-2 RNA single-stranded RNA virus target gene translation type 2 pneumocyte viral infection Viral proteins viral replication Viral RNA virus [DOI] 10.14336/AD.2021.0223 PMC 바로가기 [Article Type] Perspectives
Systematizing the genomic order and relatedness in the open reading frames (ORFs) of the coronaviruses코로나바이러스의 오픈 리딩 프레임(ORF)에서 게놈 순서와 관련성을 체계화Article Published on 2021-08-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 유전자 메커니즘, 치료법, [키워드] Accessory Accessory genes accessory protein accessory proteins agent analyzed Cluster complex conserved Coronaviridae coronavirus coronavirus disease coronavirus disease-2019 CoV CoVs effort ENCODE envelope focus Frame gene clusters Genes Genome genomes genomic genus greater mechanisms membrane naming nucleocapsid Open reading frame ORF ORF gene ORF3a ORF3b ORF3c ORF3d ORF5 ORFs pandemic Phylogeny polypeptide Protein Proteins Referral RNA genome RNA genome. RNA virus RNA viruses SARS-CoV-2 structural proteins the Spike transcriptional translational viral genome [DOI] 10.1016/j.meegid.2021.104858 PMC 바로가기 [Article Type] Article
Human Coronaviruses: Counteracting the Damage by StormReview Published on 2021-07-272022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] ADE Antibody-dependent enhancement Antiviral agents caused cell-mediated immune characteristic coronavirus COVID-19 COVID-19 pandemic CoVs Cytokine storm damage disease dysregulated elicit greater HCoV highlight highly pathogenic Human human coronaviruses IFN immune immune response immunopathology IMPROVE Infection interferon long non-coding RNA MERS-CoV obese Outbreaks over overlapping pandemic peptide progression Rapamycin regulated risk factor SARS-CoV-2 severe disease similarity storm suggested T-cell treatment approach Vaccine vaccine response [DOI] 10.3390/v13081457 PMC 바로가기 [Article Type] Review
Role of Multifunctional Cytoskeletal Filaments in Coronaviridae Infections: Therapeutic Opportunities for COVID-19 in a Nutshell코로나바이러스과 감염에서 다기능 세포골격 필라멘트의 역할: 간단히 말해서 COVID-19에 대한 치료 기회Review Published on 2021-07-192022-09-11 Journal: Cells [Category] SARS, 변종, 치료제, [키워드] acute respiratory syndrome Antiviral appearance Community Coronaviridae Coronaviridae family coronavirus COVID-19 COVID-19 research CoVs Critical cytoskeleton drug target drug targets Effect effective Efficacy filament filaments Health healthcare host cell host cells humans immunological Immunomodulatory agents involved mechanism Medicine Medicines mutant name new strain Novel coronavirus nutshell opportunity other treatments outbreak Pandemics pharmacological physiological problem problems Randomized controlled trial respiratory review role SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 significantly Spread subset subversion the Coronaviridae the disease Treatment unique Vaccine virus [DOI] 10.3390/cells10071818 PMC 바로가기 [Article Type] Review
Intranasal gene therapy to prevent infection by SARS-CoV-2 variantsSARS-CoV-2 변이체에 의한 감염을 예방하기 위한 비강내 유전자 요법Research Article Published on 2021-07-152022-09-10 Journal: PLoS Pathogens [Category] SARS, 변종, [키워드] ACE2 administration affinity airway angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animals Antiviral approach bind binding caused Cell combating coronavirus Coronaviruses countermeasure CoV COVID-19 COVID-19 pandemic CoVs demonstrated effective Efficacy evade expression Gene therapy human ACE2 humans immune response improvement infecting Infection Intervention intranasal intranasally less long-lasting monoclonal antibodies monoclonal antibody mouse model nasal Nasal spray neutralize Pandemics pathogenicity pathologic consequence Patient Population pre-existing immunity Prevent Prophylaxis Protein proximal receptor reduce respond SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 viral secrete significantly Spread tested the patient therapeutic Transmissibility unlikely vaccination Vaccinations Vaccine Vaccines variant variants variants of SARS-CoV-2 Viral viral mutation Viral mutations viral particle Viral particles Viral vector virus Vulnerable populations zoonosis [DOI] 10.1371/journal.ppat.1009544 PMC 바로가기 [Article Type] Research Article
A Combination of N and S Antigens With IgA and IgG Measurement Strengthens the Accuracy of SARS-CoV-2 SerodiagnosticsN 및 S 항원과 IgA 및 IgG 측정의 조합으로 SARS-CoV-2 혈청 진단의 정확성 강화Major Articles and Brief Reports Published on 2021-07-152022-09-10 Journal: The Journal of Infectious Diseases [Category] SARS, 진단, 치료기술, 치료법, [키워드] 229E acute phase acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Analysis antibodies antibody Antigen antigens Combination convalescent phase coronavirus coronavirus proteins correlation COVID-19 COVID-19 patient COVID-19 patients CoVs diagnostics enzyme enzyme immunoassay enzyme immunoassays estimates human CoVs humoral immune response humoral immune responses Humoral immunity IgA IgG IgM immune response immune responses immunoassay Immunoglobulin in viral increase Infection measurement MERS Microneutralization test Middle East Middle East respiratory syndrome N protein N proteins Nasopharyngeal swab Nasopharyngeal swab samples Neutralizing antibodies NL63 primary diagnosis provide RBD Receptor binding domain respiratory respiratory infection Result S antigen SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 nucleoprotein SARS-CoV-2 S1 sensitivity sera serological serology Seroprevalence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly increased Spike protein syndrome test results Viral viral spike protein virus RNA were used [DOI] 10.1093/infdis/jiab222 PMC 바로가기 [Article Type] Major Articles and Brief Reports
Environmental stability of porcine respiratory coronavirus in aquatic environmentsResearch Article Published on 2021-07-142022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] accumulate added aquatic environment aquatic environments Cell culture common cold Concentration conducted Contact coronavirus CoV COVID-19 CoVs droplet experiment faster filtered human disease human-to-human transmission inactivation Interaction MERS microbial Middle East North Sea nucleases PBS Proteases respiratory Respiratory Coronavirus responsible SARS-CoV-2 Scheldt Spread stability TCID temperature terrestrial testicle transmission of SARS-CoV-2 Treatment viral inactivation Viral load virus virus titre [DOI] 10.1371/journal.pone.0254540 PMC 바로가기 [Article Type] Research Article
The Many Faces of JAKs and STATs Within the COVID-19 StormImmunology Published on 2021-07-132022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] “cytokine storm” Activation activator Cell consequence coronavirus 2 COVID-19 CoVs cytokine cytokine receptor Cytokine release syndrome Cytokine storm downstream Effect elevated face global pandemic Health immunologically Jak JAK inhibitor JAK-STAT pathway janus kinase positive-sense Protein respiratory resulting RNA virus SARS-CoV-2 signal Signaling STAT storm the SARS-CoV-2 transducer triggered [DOI] 10.3389/fimmu.2021.690477 PMC 바로가기 [Article Type] Immunology
Coronavirus genomic nsp14-ExoN, structure, role, mechanism, and potential application as a drug target코로나바이러스 게놈 nsp14-ExoN, 구조, 역할, 메커니즘 및 약물 표적으로서의 잠재적 응용Review Published on 2021-07-012022-09-11 Journal: Journal of medical virology [Category] SARS, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antiviral therapy antivirals coding Combination coronavirus coronavirus disease Coronavirus disease 2019 CoV COVID-19 CoVs domain drug target drugs Effect ExoN Exoribonuclease genome replication genomic global pandemic healthcare highlight human coronavirus human coronaviruses identify mechanism nonstructural protein 14 nsp14 nsp14-ExoN nucleoside nucleoside analog nucleoside analogs nucleotide nucleotides Proofreading Protein Replication required RNA RNA recombination SARS-CoV-2 severe acute respiratory syndrome Coronavirus target targets Transcription [DOI] 10.1002/jmv.27009 PMC 바로가기 [Article Type] Review