Combining Monophosphoryl Lipid A (MPL), CpG Oligodeoxynucleotide (ODN), and QS-21 Adjuvants Induces Strong and Persistent Functional Antibodies and T Cell Responses against Cell-Traversal Protein for Ookinetes and Sporozoites (CelTOS) of Plasmodium falciparum in BALB/c MiceArticle Published on 2019-05-212024-08-28 Journal: Infection and Immunity [Category] 말라리아, [키워드] adjuvants CpG malaria MPL PfCelTOS Plasmodium falciparum QS-21 Vaccine
Cell-traversal protein for ookinetes and sporozoites (CelTOS) formulated with potent TLR adjuvants induces high-affinity antibodies that inhibit Plasmodium falciparum infection in Anopheles stephensi세포 통과 단백질인 ookinetes와 sporozoites (CelTOS)가 강력한 TLR 보조제를 사용하여 제조되어 Anopheles stephensi에서 Plasmodium falciparum 감염을 억제하는 고친화성 항체를 유도합니다.Research Published on 2019-04-242024-08-11 Journal: Malaria Journal [Category] 말라리아, [키워드] CelTOS CpG Plasmodium falciparum Poly I:C Transmission-reducing activity (TRA) [DOI] 10.1186/s12936-019-2773-3 PMC 바로가기 [Article Type] Research
The In Ovo Delivery of CpG Oligonucleotides Protects against Infectious Bronchitis with the Recruitment of Immune Cells into the Respiratory Tract of ChickensCommunication Published on 2018-11-152022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] activating avian macrophage Bacterial CD4+ CD4+ cell CD8α+ cell chicken Cluster CpG CpG oligonucleotide days post infection delivery determine embryonic IBV IBV infection immune response In ovo Infectious Bronchitis Virus interferon lung macrophages mechanism morbidity and mortality mRNA oligonucleotide PROTECT protective effect recruitment reduce reduced respiratory respiratory tract shown signaling pathway significantly higher survival rate T lymphocytes Toll-like receptor tract viral infections [DOI] 10.3390/v10110635 PMC 바로가기 [Article Type] Communication
Within-patient mutation frequencies reveal fitness costs of CpG dinucleotides and drastic amino acid changes in HIV환자 내 돌연변이 빈도는 CpG 디뉴클레오티드의 적합성 비용과 HIV의 급격한 아미노산 변화를 나타냅니다.Research Article Published on 2018-06-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition Amino acid amino acid change amino acid changes approach calculated contribute costly CpG determine dinucleotide distribution drastic Evolution Evolvability expected Factor Frequency help high mutation rate HIV host’s immune system in vivo lead mean frequency microbes mutant mutant frequencies Mutation mutation rate mutations Non-synonymous Non-synonymous mutation nonsense mutation Nonsense mutations patients Population power predict reduce replicate synonymous the mean transition mutation transition mutations Trigger variety Viral viral fitness virus [DOI] 10.1371/journal.pgen.1007420 PMC 바로가기 [Article Type] Research Article
Consensus M2e peptide conjugated to gold nanoparticles confers protection against H1N1, H3N2 and H5N1 influenza A virusesArticle Published on 2017-05-012023-06-14 Journal: Antiviral Research [Category] Fulltext, 신종인플루엔자, [키워드] adjuvants CpG Gold nanoparticles influenza vaccine intranasal vaccination M2e universal influenza vaccine [DOI] 10.1016/j.antiviral.2017.01.021 PMC 바로가기
Positive Contribution of Adjuvanted Influenza Vaccines to the Resolution of Bacterial SuperinfectionsArticle Published on 2016-06-152023-06-24 Journal: The Journal of Infectious Diseases [Category] 신종인플루엔자, [키워드] bacterial superinfection CpG Influenza LTK63 MF59 Staphylococcus aureus Vaccine adjuvants [DOI] 10.1093/infdis/jiw048
Fibronectin EDA and CpG synergize to enhance antigen-specific Th1 and cytotoxic responsesArticle Published on 2016-05-052023-06-18 Journal: Vaccine [Category] B형 간염, [키워드] Adaptive immunity adjuvant Cancer vaccine CpG FNIII EDA Hepatitis B virus Pattern recognition receptors Toll-like receptors [DOI] 10.1016/j.vaccine.2016.03.057 PMC 바로가기
Tailoring Subunit Vaccine Immunity with Adjuvant Combinations and Delivery Routes Using the Middle East Respiratory Coronavirus (MERS-CoV) Receptor-Binding Domain as an AntigenResearch Article Published on 2014-11-182022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] adjuvant antibody Antigen BALB/c mice Cell-mediated immunity cellular immune responses cellular immunity Combination CpG Critical cytokine production delivery effective elicited ELISpot assay evaluated Freund’s adjuvant humoral Humoral immunity hydroxide hypothesised IFA IFN-γ IgG immune response Immunity immunized immunogenic IMPROVE indicated intramuscularly investigated MERS-CoV MERS-CoV RBD mice Middle East Modification murine Neutralizing antibodies neutralizing antibody offered pandemic Protein purified RBD regimen respiratory respiratory syndrome coronavirus robust route rRBD spot-forming cell subunit T-cell Response the receptor-binding domain vaccination Vaccine was tested [DOI] 10.1371/journal.pone.0112602 PMC 바로가기 [Article Type] Research Article
Maximal immune response and cross protection by influenza virus nucleoprotein derived from E. coli using an optimized formulationArticle Published on 2014-11-012023-06-24 Journal: Virology [Category] 신종인플루엔자, [키워드] Al(OH)(3) CpG influenza A virus nucleoprotein protective immunity Protein subunit vaccines. [DOI] 10.1016/j.virol.2014.08.008
Heterozygous De Novo and Inherited Mutations in the Smooth Muscle Actin ( ACTG2 ) Gene Underlie Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome평활근 액틴(ACTG2) 유전자의 이형 접합체 및 유전 돌연변이는 거대포낭-소결장-장 연동운동부전 증후군의 기초가 됩니다.Research Article Published on 2014-03-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] abdominal surgeries abdominal surgery ACTG2 Actin Actins affected affecting arginine arginine residues bladder catheterization codon Cohort cohort of patient component components contractile protein contractile proteins CpG de novo mutation de novo mutations dependent on described description diagnosed dinucleotide disease disorder DNA ENCODE enteric smooth muscle Families Finnish followed by food gastrointestinal problem gastrointestinal problems Genes heterozygous heterozygous mutation Hypoperistalsis identify initial intestinal intestinal pseudo-obstruction intestine less majority megacystis megacystis-microcolon-intestinal hypoperistalsis syndrome microcolon Missense mutation Missense mutations missense variant MMIHS muscle muscle contractile units muscle disease Muscle function Mutation mutations obstruction organ parenteral nutrition Patient patients phenotype powerful tool provide radiologist remained responsible Sanger sequencing Smooth smooth muscle smooth muscle disease Spectrum subjects syndrome the disease total parenteral nutrition Treatment unique urinary catheterization variant visceral whole-exome sequencing γ2 enteric actin [DOI] 10.1371/journal.pgen.1004258 PMC 바로가기 [Article Type] Research Article