COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis
Research
[키워드] ACE2
activated
acute respiratory syndrome
airway
Analysis
average
CCL2
CCL20
CCL3
CCR1
CCR5
cell interaction
clinical observation
clinically
contribute
coronavirus
correlated
COVID-19
COVID-19 severity
Critical
Critical case
Critical disease
CXCL1
CXCL10
CXCL3
entry receptor
epithelial
epithelial cell
epithelial cell type
exhibited
expressing
expression
expression profiles
FIVE
healthy controls
Hyperactivation
IL1B
IL8
immune
immune cells
immune response
increase in
indicated
Infection
Inflammatory
inflammatory macrophage
Interaction
interferon
Lung injury
mechanism
moderate
nasopharyngeal
pathway
patients with COVID-19
patients with moderate
performed
Respiratory failure
SARS-CoV-2
severe coronavirus disease
single-cell
Single-cell RNA sequencing
suppress
the SARS-CoV-2
tissue damage
TNF
transcriptional difference
[DOI] 10.1038/s41587-020-0602-4 [Article Type] Research
[DOI] 10.1038/s41587-020-0602-4 [Article Type] Research