Middle East respiratory syndrome coronavirus ORF4b protein inhibits type I interferon production through both cytoplasmic and nuclear targetsArticle Published on 2015-12-032022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] abrogated Analysis Antiviral antiviral response antiviral responses antiviral signaling Asia binding contribute coronavirus country cytoplasm cytoplasmic determinant Europe evade highly pathogenic IFN IFN-α/β IFN-β IKKε inhibit Interaction interferon IRF3 IκB MAVS MDA5 mechanism MERS-CoV Middle East mitochondrial molecular interaction Mortality North nuclear nuclear localization signal nucleus ORF4b other coronavirus Pathogenesis pathogenicity Phosphorylation previous study Protein Regulatory respiratory syndrome coronavirus RIG-I shown significantly spread to subsequent suppress TANK target TBK1 the interferon therapeutic Type I IFN type I interferon virulence virus [DOI] 10.1038/srep17554 PMC 바로가기 [Article Type] Article
Heterologous Aggregates Promote De Novo Prion Appearance via More than One Mechanism이종 골재는 하나 이상의 메커니즘을 통해 De Novo Prion 모양을 촉진합니다.Research Article Published on 2015-01-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence aggregate aggregates aggregation appear appearance asparagine Cell cells cellular chaperone characteristic Colocalization conformational cytoplasm de novo detect disease domains eukaryotic form Glutamine Heterologous Interaction lack mechanisms molecular MOST neurodegenerative no interaction open overexpressed overexpression pathway periphery phenotypic phenotypic traits physical Polymer prevalent prion promote Protein Proteins PSI required seed stimulated the cell traits vacuole variant while yeast [DOI] 10.1371/journal.pgen.1004814 PMC 바로가기 [Article Type] Research Article
The PDZ-Binding Motif of Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Is a Determinant of Viral PathogenesisResearch Article Published on 2014-08-142022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] activate activating Activation acute respiratory syndrome addition administration analyses assays caused Cell cellular complementary confocal microscopy coronavirus cytoplasm decrease decreased expression Deleterious demonstrated determinant domain E protein Elimination envelope Epidemic exacerbated functional genetics highlight immune response immunopathology in vivo increase in induce infecting Infection Inflammation Inflammatory cytokine Inflammatory cytokines inhibitor interact Interaction interactions involved lung lung damage MAPK mice modulating Mortality motif nucleus overexpression parental pathway potential therapeutic target Protein Proteins proteomic recombinant reduce reduction in respiratory SARS-CoV SARS-CoV E SARS-CoV infected cells SARS-CoV infection siRNA survival triggered triggering virulence virus virus attenuation was reduced yeast [DOI] 10.1371/journal.ppat.1004320 PMC 바로가기 [Article Type] Research Article
Molecular Characterizations of Subcellular Localization Signals in the Nucleocapsid Protein of Porcine Epidemic Diarrhea VirusArticle Published on 2014-03-132022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Amino acid antibiotic Cell cellular characterization chromosome CHROMOSOME region maintenance 1 confocal microscopy coronavirus Critical cytoplasm epidemic diarrhea eukaryotic fluorescent full-length functional fusion protein GFP Infection inhibited Localization Mutation N protein NES nuclear nuclear export signal nucleocapsid nucleocapsid protein Nucleolus pathway PEDV Porcine epidemic diarrhea virus Protein signal site-directed mutagenesis subcellular localization signals the N protein VERO E6 cells virus virus replication [DOI] 10.3390/v6031253 PMC 바로가기 [Article Type] Article
Infectious Bronchitis Virus Generates Spherules from Zippered Endoplasmic Reticulum MembranesResearch Article Published on 2013-10-222022-10-29 Journal: mBio [Category] Coronavirus, MERS, [키워드] acute respiratory syndrome alphaviruses Betacoronavirus candidate Cell cell line cell types cellular cellular membranes characterized cisternae CM complex coronavirus Coronaviruses Culture cultures cytoplasm electron Endoplasmic reticulum epithelial cell Ex vivo generate IBV IBV infection IBV-infected cell in viral induce infected cells Infection Infectious Bronchitis Virus interior invagination lack mammalian cell mean membrane mouse hepatitis virus organ outer membrane pathogen platform positive-sense positive-sense single-stranded RNA related replication complexes Reticulum RNA RNA synthesis RNA virus RNA viruses SARS-CoV sealed spherule spherules Structure thought tissue tomography tracheal Vesicle viral replication Viral RNA virus [DOI] 10.1128/mBio.00801-13 PMC 바로가기 [Article Type] Research Article
Only One Isoform of Drosophila melanogaster CTP Synthase Forms the CytoophidiumDrosophila melanogaster CTP Synthase의 단 하나의 Isoform이 Cytoophidium을 형성합니다Research Article Published on 2013-02-142022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition ATP ATP synthase Author Bacteria biogenesis biological processe biological processes block Cell cell types cells conserved cytoplasm demonstrated different disrupt disrupting dissect distribution DNA and RNA domain Drosophila Drosophila melanogaster ectopic expression embryos energy metabolism enzyme example expression expression profiles form growth human cells identify independent induce isoform locus metabolism Mitochondria mutants Mutation nucleotide nucleotides nucleus organism overexpression provide shown Structure subcellular distribution subcellular structure Synthase synthase gene transcript while yeast [DOI] 10.1371/journal.pgen.1003256 PMC 바로가기 [Article Type] Research Article
Severe acute respiratory syndrome coronavirus accessory proteins 6 and 9b interact in vivoArticle Published on 2012-07-202022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] accessory protein accessory proteins acute respiratory syndrome Amino acid Analysis analyzed approach cellular conditions coronavirus Coronaviruses cytoplasm described eight ENCODE experiment Factor functions Genome homology immunoprecipitation in vivo infective Interaction involved LC–MS pathogenicity Protein Protein 6 Protein 9b protein–protein interactions Proteins proteomic Replication SARS Coronavirus SARS-CoV SARS-CoV infected cell SARS-CoV infected cells severe shown structural protein Viral protein virus [DOI] 10.1016/j.virusres.2012.07.012 PMC 바로가기 [Article Type] Article
Mechanisms of Coronavirus Cell Entry Mediated by the Viral Spike ProteinReview Published on 2012-06-202022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] binding cell tropism Characteristics commonality conformational change coronavirus coronavirus S protein Coronaviruses cytoplasm different driven by Entry mechanism feature fusion fusion protein highlight Host host cell host cell membrane Mediated nucleocapsid Pathogenesis pathogenicity primary determinant Proteins proteolytic activation receptor Receptor binding replicate responsible RNA virus spike spike glycoprotein the S protein Transmission Trigger viral entry virus entry [DOI] 10.3390/v4061011 PMC 바로가기 [Article Type] Review
PLP2 of Mouse Hepatitis Virus A59 (MHV-A59) Targets TBK1 to Negatively Regulate Cellular Type I Interferon Signaling PathwayResearch Article Published on 2011-02-182022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Activation acute respiratory syndrome assays catalytic domain cells cellular complex conserved coronavirus cytoplasm deubiquitinase domain dose-dependent manner DUB ENCODE Evidence experiment finding identification IFN IFN signaling IFN signaling pathway IFN transcription IFN-β in vitro inactivated inactive Infection inhibit inhibited innate immune system IRF3 MHV-A59 mouse mouse hepatitis virus nonstructural protein 3 Nsp3 nuclear translocation overexpression Papain-like protease phosphorylate PLP2 Prevent principal Proteins receptor reduced Regulatory Replication reporter shown Spread supported target TBK1 TNF TRAF3 Treatment Type type I interferon upstream [DOI] 10.1371/journal.pone.0017192 PMC 바로가기 [Article Type] Research Article
Distinct Patterns of IFITM-Mediated Restriction of Filoviruses, SARS Coronavirus, and Influenza A VirusResearch Article Published on 2011-01-062022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] Acidic Author bypasse bypassed cathepsin L Cell cellular cellular tropism circumvent compared Control cytoplasm described did not reduce Ebola Ebola virus Endocytic pathway ENhance example Express expression Factors Filovirus glycoprotein highly pathogenic IAV IFITM IFITM1 IFITM3 indicate Infection infectious influenza A virus inhibit inhibited innate immune system interfere late stage less limit lysosomal modulate murine observation pathogenic viruses pattern plasma membrane Protein Proteins pseudovirions receptor Replication restrict restriction restriction factor SARS Coronavirus SARS-CoV transmembrane transmembrane protein Treatment viral replication virion virus viruses [DOI] 10.1371/journal.ppat.1001258 PMC 바로가기 [Article Type] Research Article