Blood exchange transfusion with dexamethasone and Tocilizumab for management of hospitalized patients with sickle cell disease and severe COVID-19: Preliminary evaluation of a novel algorithm겸상적혈구병 및 중증 COVID-19 입원 환자 관리를 위한 덱사메타손 및 토실리주맙을 사용한 혈액 교환 수혈: 새로운 알고리즘의 예비 평가Article Published on 2022-07-012022-09-12 Journal: American journal of hematology [Category] 진단, [키워드] Algorithm Cell Dexamethasone disease hospitalized patient management [DOI] 10.1002/ajh.26563 PMC 바로가기 [Article Type] Article
Clinical characteristics, risk factors, and rate of severity of a nationwide COVID-19 Saudi cohortResearch article Published on 2022-07-012022-10-05 Journal: Saudi Journal of Biological Sciences [Category] 임상, [키워드] 95% CI age Analysis baseline Characteristics clinical Clinical characteristics clinical factor Clinical severity Cohort Comorbidity COVID-19 COVID-19 case COVID-19 patients COVID-19 severity COVID19 COVID19 patient death rate Deceased demographic characteristics demographics Dexamethasone Diabetes Mellitus Elderly patient evaluate Favipiravir female patient Gender hazard highest Hospital stay Hospitalization Hospitalized hospitalized patient hypertension increased risk indicate Invasive mechanical ventilation invasive respiratory support Jeddah lymphocyte male Male sex medications Mortality multivariate logistic regression neutrophil obesity objective Odds ratio oxygen participant Patient prevalent prospective cohort study recruited required Result Risk factors Saudi Arabia severity stratified [DOI] 10.1016/j.sjbs.2022.103315 [Article Type] Research article
Factors associated with dexamethasone efficacy in COVID-19. A retrospective investigative cohort studyArticle Published on 2022-07-012023-07-08 Journal: Journal of medical virology [Category] COVID19(2023년), [키워드] Antibiotics COVID-19 Dexamethasone intensive care unit Mortality [DOI] 10.1002/jmv.27712 PMC 바로가기
The benefit of dexamethasone in patients with COVID-19 infection is preserved in patients with diabetesArticle Published on 2022-07-012023-07-08 Journal: Diabetes, obesity & metabolism [Category] COVID19(2023년), [키워드] COVID-19 Dexamethasone diabetes Mortality [DOI] 10.1111/dom.14692 PMC 바로가기
Reduced fixed dose tocilizumab 400 mg IV compared to weight-based dosing in critically ill patients with COVID-19: A before-after cohort studyResearch article Published on 2022-07-012022-10-05 Journal: The Lancet Regional Health - Americas [Category] 바이오마커, [키워드] 28-day mortality assumed benefit Clinical outcome Cohort cohort study comparable cost-effectiveness Covid cytokine storm COVID-19 COVID-19 patient Critically ill Critically ill patient CRP demonstrated Dexamethasone dose equity family feasible finding fixed dose foundation funding groups Inflammation inhibitor interleukin-6 no significant difference pair-wise comparison Patient patients physiological response receiving reduce mortality reduction response Scholarship severe COVID-19 supported Taylor the patient threshold Tocilizumab treated with COVID-19 [DOI] 10.1016/j.lana.2022.100228 [Article Type] Research article
Delayed dexamethasone treatment at initiation of oxygen supplementation for coronavirus disease 2019 is associated with the exacerbation of clinical conditionArticle Published on 2022-07-012023-07-08 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), [키워드] acute respiratory distress syndrome Coronavirus disease 2019 Dexamethasone mechanical ventilation Mortality [DOI] 10.1016/j.jiac.2022.03.007 PMC 바로가기
Major candidate variables to guide personalised treatment with steroids in critically ill patients with COVID-19: CIBERESUCICOVID studyObservational Study Published on 2022-07-012022-10-04 Journal: Intensive care medicine [Category] 임상, [키워드] Administered administration affected age Analysis assessment Bacterial baseline benefit Care clinically Corticosteroid corticosteroid treatment Corticosteroids covariate COVID-19 COVID-19 patient Critically ill Critically ill patient Dexamethasone dosage dose doses of corticosteroid early administration Evidence failure higher risk hospitalisation ICU ICU admission ICUs Illness severity in-hospital mortality increased risk Inflammation information intensive care interaction term Invasive mechanical ventilation investigated Laboratory lower risk Major mechanical ventilation Modification Mortality multivariable analysis no effect nosocomial Observational cohort study organ damage Patient patients with COVID-19 performed personalised Pneumonia potential benefit Primary outcome Protective receiving severe coronavirus disease severity Significant SOFA Spanish steroid subgroup subgroups subgroups of patient symptom onset systemic corticosteroid Treatment use of corticosteroid variable with COVID-19 [DOI] 10.1007/s00134-022-06726-w PMC 바로가기 [Article Type] Observational Study
Corticosteroids and superinfections in COVID-19 patients on invasive mechanical ventilationObservational Study Published on 2022-07-012022-10-05 Journal: The Journal of Infection [Category] COVID19(2023년), SARS, 임상, [키워드] age ARDS Autoimmune disease Characteristics Clinical characteristics COVID-19 COVID-19 patient COVID-19 patients Critically ill determine Dexamethasone examined fungal Fungal infection ICU incidence Infection Invasive fungal infections Invasive mechanical ventilation mechanical ventilation mechanically ventilated men multicentre Multiple regression analysis not differ Patient Pneumonia receiving reported Retrospective study Standard of care Standard therapy superinfection Superinfections survival therapy with COVID-19 [DOI] 10.1016/j.jinf.2022.05.015 PMC 바로가기 [Article Type] Observational Study
Dexamethasone exposure in normal-weight and obese hospitalized COVID-19 patients: An observational exploratory trialObservational Study Published on 2022-07-012022-10-04 Journal: Clinical and translational science [Category] 임상, [키워드] 95% CI affected AUC benefit blood sample BMI body mass index C max collected Concentration conducted COVID-19 COVID-19 patients decrease Dexamethasone dose exploratory exploratory study form Gender Geneva University Hospital group Hospitalization hospitalized COVID-19 hospitalized patients independent risk factor Infection information men no significant difference obese obese patients outcomes pandemic Patient recovery study significantly Standard of care the mean therapy Treatment Trial were measured women [DOI] 10.1111/cts.13297 PMC 바로가기 [Article Type] Observational Study
Effect of Casirivimab/Imdevimab Treatment on Serum Type I Interferon Levels in SARS-CoV-2 InfectionSARS-CoV-2 감염에서 혈청 I형 인터페론 수치에 대한 Casirivimab/Imdevimab 치료의 효과Observational Study Published on 2022-06-272022-09-12 Journal: Viruses [Category] COVID19(2023년), SARS, 임상, 진단, [키워드] addition administration Antibody-dependent enhancement Blood level Casirivimab Cohort Comparator group consecutive patient COVID-19 cytokine Dexamethasone early phase Effect enrolled evaluated Hospitalized Hypoxemia IFN-I IFN-α IFN-β Imdevimab immune response immunoassay Infection innate immune response interferon Level on type onset of symptoms Patient patients with SARS-CoV-2 prospective observational study recruited Remdesivir SARS-CoV-2 SARS-COV-2 infection significantly temperature therapeutic effect Treatment Type type I interferon were assessed [DOI] 10.3390/v14071399 PMC 바로가기 [Article Type] Observational Study