downregulated – Page 9 – Communicable Diseases Research

The relationship between cytokine and neutrophil gene network distinguishes SARS-CoV-2–infected patients by sex and age

사이토카인과 호중구 유전자 네트워크 사이의 관계는 SARS-CoV-2 감염 환자를 성별과 연령으로 구분합니다

Research Article

Published on 2021-05-242022-09-10
Journal: JCI Insight [Category] SARS, 유전자 메커니즘,

Should We Be Concerned about the Association of Diabetes Mellitus and Periodontal Disease in the Risk of Infection by SARS-CoV-2? A Systematic Review and Hypothesis

Systematic Review

Published on 2021-05-132022-10-30
Journal: Medicina [Category] COVID-19, SARS,

[키워드] ACE2 addition angiotensin-converting enzyme 2 article articles association bidirectional blood glucose cascade Case report Cell characterized clinical evidence Concerned conducted correlation COVID-19 cytokine profile diabetes Diabetes Mellitus disease distribution downregulated English language event Evidence explain expression Final FIVE glycemia Health hyperglycemia hypotheses Hypothesis identify immunomodulatory imperative increase increased risk Inflammatory inflammatory disorder insulin Interaction issue key factor kidneys lack lung metabolic disorder new SARS-CoV-2 overexpression pathway patients periodontal periodontal disease periodontal tissue Periodontitis Perspective Primary outcome Randomized controlled trial RAS resulting review risk SARS-CoV-2 SARS-COV-2 infection secretion Support systematic review tongue triggering type 2 diabete Type 2 diabetes mellitus Web of Science
[DOI] 10.3390/medicina57050493 PMC 바로가기 [Article Type] Systematic Review

Downregulation of ACE2 expression by SARS-CoV-2 worsens the prognosis of KIRC and KIRP patients via metabolism and immunoregulation

Research Paper

Published on 2021-05-102022-10-29
Journal: International Journal of Biological Sciences [Category] COVID-19, SARS,

[키워드] Accuracy ACE2 ACE2 expression acute respiratory syndrome animal model Atla bioinformatics Cancer Cancer patients Cancer therapy Cell clinical information clinical risk coronavirus correlated correlation database diagnosing downregulated downregulation enzyme exhibit expression function Gene Expression Gene Expression Omnibus GEO high risk host cell human tissues immune immune infiltration immunoregulation involved kidney metabolic pathway metabolism not correlated overall survival overlap Patient patient survival patients Predictive Prognosis renal Renal cancer SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected cell searched significantly survival Symptoms target tissue TMPRSS2 transmembrane serine protease upregulated Xena
[DOI] 10.7150/ijbs.57802 PMC 바로가기 [Article Type] Research Paper

Anti-TNF-α agents Modulate SARS-CoV-2 Receptors and Increase the Risk of Infection Through Notch-1 Signaling

Immunology

Published on 2021-05-062022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, SARS,

[키워드] ACE2 ACE2 expression acute respiratory syndrome Angiotensin-converting enzyme Anti-TNF-α anti-TNF-α Autoimmune disease blocking cellular entry coronavirus COVID-19 COVID-19 pandemic COVID19 Critical demonstrated downregulated downstream enzyme expression healthy control IL-6 Immunity increase Infection inflammatory condition investigated leukemia Macrophage macrophages mechanism modulation monoclonal antibody Mycobacterium myeloid cell Notch pandemic Patient patients plasma rheumatoid arthritis risk SARS-CoV-2 Signaling significantly lower Standard therapy susceptibility TACE therapy THP-1 transmembrane serine protease treated Treatment upregulated viability
[DOI] 10.3389/fimmu.2021.641295 PMC 바로가기 [Article Type] Immunology

SARS-CoV-2 Viral Entry Proteins in Hyperandrogenemic Female Mice: Implications for Women with PCOS and COVID-19

안드로겐과다증 암컷 마우스의 SARS-CoV-2 바이러스 진입 단백질: PCOS 및 COVID-19가 있는 여성에게 미치는 영향

Article

Published on 2021-04-252022-09-12
Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 진단,

[키워드] ACE2 ACE2 mRNA ACE2 protein ADAM ADAM17 Affect androgen Androgen receptor androgens angiotensin angiotensin I angiotensin I converting enzyme 2 Body body composition body weight Brain cardiometabolic cathepsin cathepsin L causative agent cecum characterized Comorbidities COVID-19 COVID-19 pathology determined by Dihydrotestosterone disorder downregulated dysfunction elevated ELISA Endocrine enzyme fasting fasting glucose fat furin Glucose heart highlight host cell host cells host proteases hyperandrogenism infect kidney lean mass lung male mass mice morphology Mortality mRNA multiple tissue multiple tissues obesity organ systems ovarian Ovary ovulatory pathology Patient Polycystic polycystic ovary Polycystic ovary syndrome priming protease proteases Tmprss2 Protein protein level protein levels qPCR quantified receptor regulate renal risk risk factor Risk factors RT-qPCR SARS-CoV-2 SARS-CoV-2 entry serum severe COVID-19 severity small intestine tissues TMPRSS2 TMPRSS4 treated Treatment upregulated Urine was determined was measured Western-blot with COVID-19 women
[DOI] 10.3390/ijms22094472 PMC 바로가기 [Article Type] Article

Evidence of a dysregulated vitamin D endocrine system in SARS-CoV-2 infected patient’s lung cells

SARS-CoV-2에 감염된 환자의 폐 세포에서 조절되지 않는 비타민 D 내분비계의 증거

Article

Published on 2021-04-212022-09-10
Journal: Scientific Reports [Category] MERS, 유전자 메커니즘,

[키워드] affected Analysis applied BALF BALF cell BALF cells Bronchoalveolar lavage fluid Cell cell cycle cells computational approach Computational approaches conserved CYP27A1 cytokine signaling dataset differentially expressed differentially expressed gene Differentially expressed genes downregulated dysregulated eight elements Endocrine endocrine system Evidence evidence of Gene Expression Genes healthy individuals immune system indirect mechanism infected cells infected with SARS-CoV-2 Infection Interaction Level lung cell lung cells modulated motif NF-κB pathway Patient patients predicted provided receptor reduced Regulation retinoid SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected cells Signaling status the cells transcriptomic transcriptomics Vitamin D vitamin D endocrine system Vitamin D receptor
[DOI] 10.1038/s41598-021-87703-z PMC 바로가기 [Article Type] Article

Differentially expressed immune response genes in COVID-19 patients based on disease severity

질병 중증도에 따라 COVID-19 환자에서 차등적으로 발현되는 면역 반응 유전자

Research Paper

Published on 2021-04-152022-09-10
Journal: Aging (Albany NY) [Category] SARS, 유전자 메커니즘,

[키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed Antiviral antiviral genes APOBEC3G Apolipoprotein Apolipoprotein B appear blood sample Blood samples case-control study catalytic changes in chemokine chemokines city collected coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CXCL10 CXCL11 CXCL9 cytokine Cytokines death decreased expression disease Disease progression disease severity domain downregulated dysregulated immune response dysregulated immune responses enzyme expressed FADD Gene Expression genes encoding healthy control healthy controls healthy subject Host IFN IFNA1 IFNA2 IFNAR1 IL12A IL12B IL15 IL1B IL6 Illness severity immune response gene immune response genes immune responses induction IRF7 ISG15 microRNA mRNA MX1 Patient patients PCR progression Proinflammatory cytokine proinflammatory cytokines Protein recovered COVID-19 patient recruited respiratory RNA extraction SARS-CoV-2 SARS-COV-2 infection second severe acute respiratory syndrome Coronavirus Signaling significantly thought TLR8 TLR9 type I interferon underlie upregulated
[DOI] 10.18632/aging.202877 PMC 바로가기 [Article Type] Research Paper

Whole-Transcriptome RNA Sequencing Reveals Significant Differentially Expressed mRNAs, miRNAs, and lncRNAs and Related Regulating Biological Pathways in the Peripheral Blood of COVID-19 Patients

전체 전사체 RNA 시퀀싱은 COVID-19 환자의 말초 혈액에서 유의미하게 차별적으로 발현된 mRNA, miRNA, lncRNA 및 관련 조절 생물학적 경로를 나타냅니다

Research Article

Published on 2021-04-012022-09-10
Journal: Mediators of Inflammation [Category] MERS, SARS, 유전자 메커니즘,

[키워드] “cytokine storm” acute respiratory syndrome acute respiratory syndrome coronavirus AKT1 Analysis Antigen antigen processing Biological biosynthetic characterized China coding collected competing control group controls coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 sample COVID-19 samples CXCL8 cytokine cytokine production Cytokine storm cytotoxicity diagnostic biomarker Diagnostic biomarkers differentially expressed downregulated enrichment analysis excessive cytokine production FCGR2A Functional enrichment analyses Gene ontology glycogen ground-glass opacity healthy controls healthy donor healthy donors highlight hub genes indicated Inflammation Interaction involved leukocyte leukocytes lncRNA long noncoding RNA lung tissues lymphocyte Lymphocytes mechanism Messenger RNA messenger RNAs microRNA MicroRNAs Migration miRNA miRNAs mRNA mRNAs noncoding RNA Noncoding RNAs pandemic Pathogenesis peripheral Peripheral blood positive potential mechanism potential mechanisms PPI presenting protein-protein interaction Regulating Regulation Regulatory respiratory resulting RNA SARS-CoV-2 selected Sequencing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 signaling pathway Significant significantly STAT3 systemic inflammation T cell T cell activation target the healthy therapeutic tissue TLR2 TNFRSF1B upregulated
[DOI] 10.1155/2021/6635925 PMC 바로가기 [Article Type] Research Article

Profiles of Peripheral Immune Cells of Uncomplicated COVID-19 Cases with Distinct Viral RNA Shedding Periods

Article

Published on 2021-03-192022-10-28
Journal: Viruses [Category] COVID-19, SARS,

Network Analysis and Transcriptome Profiling Identify Autophagic and Mitochondrial Dysfunctions in SARS-CoV-2 Infection

네트워크 분석 및 전사체 프로파일링으로 SARS-CoV-2 감염에서 자가포식 및 미토콘드리아 기능 장애 식별

Genetics

Published on 2021-03-162022-08-13
Journal: Frontiers in Genetics [Category] 유전자 메커니즘,

[키워드] A549 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Antiviral antiviral signaling autophagic autophagic flux autophagy autophagy genes biological processe biological processes Calu3 chemokines co-expression network analysis contributing to coronavirus COVID-19 Critical downregulated downregulating drugs targeting expression of gene expression profile expression profiles GSK3B help host cell host cells IAV infected cell infected cells Infection infections Inflammation Inflammatory Influenza influenza A influenza A virus interferon signaling interferon-stimulated genes Intervention involved lung cell line lung cell lines lysosome acidification MERS MERS-CoV mitochondrial mitochondrial complex I mitochondrial fission Mitochondrial function mitochondrial ribosomal mTOR mTOR expression nasopharyngeal sample network Perturbation perturbations Profiling respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected cells severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 SNAP29 tested transcriptional response transcriptomics Tripartite Motif upregulating upregulation validation study Viral viral pathogenesis viral replication
[DOI] 10.3389/fgene.2021.599261 PMC 바로가기 [Article Type] Genetics