Simultaneous monitoring of eight human respiratory viruses including SARS-CoV-2 using liquid chromatography-tandem mass spectrometry액체 크로마토그래피-탠덤 질량분석기를 이용한 SARS-CoV-2를 포함한 8종의 인간 호흡기 바이러스 동시 모니터링Article Published on 2022-08-042022-09-11 Journal: Scientific Reports [Category] SARS, 신종인플루엔자, 진단, 치료기술, 치료제, [키워드] 229E absence acute infection acute respiratory syndrome coronavirus applied Chain Reaction characterisation clinical sample clinical samples conditions coronavirus 2 Coverage Culture Diagnosis eight H1N1 H3N2 human respiratory virus Infection Influenza Influenza A/H1N1 influenza B information liquid Liquid chromatography mass spectrometry moderate not used nucleoprotein OC43 Orf9b peptide peptides polymerase chain polymerase chain reaction positive presence or absence Protein proteomics provide Replication respiratory respiratory virus respiratory viruses reverse transcriptase Reverse transcriptase polymerase chain reaction RT-PCR SARS-CoV-2 SARS-CoV-2 ORF9b serology Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Simultaneous specimens Tandem mass spectrometry the SARS-CoV-2 transcriptase viral infection Viral load Viral protein Viral proteins Viral RNA virus virus replication [DOI] 10.1038/s41598-022-16250-y PMC 바로가기 [Article Type] Article
Thromboembolic events in COVID-19 ambulatory patients: An observational study about incidence, and thromboprophylaxis outcomesObservational Study Published on 2022-08-042022-10-05 Journal: PLoS ONE [Category] 임상, [키워드] age ambulatory patients Cohort Complication complications conducted COVID-19 defined described eight event FIVE Hemorrhagic hemorrhagic event high risk incidence LMWH management occurred outcome Patient prophylactic strategy rivaroxaban thromboembolic complication Thromboprophylaxis venous venous thromboembolic [DOI] 10.1371/journal.pone.0270195 PMC 바로가기 [Article Type] Observational Study
Identifying novel host-based diagnostic biomarker panels for COVID-19: a whole-blood/nasopharyngeal transcriptome meta-analysisCOVID-19에 대한 새로운 호스트 기반 진단 바이오마커 패널 식별: 전혈/비인두 전사체 메타 분석Meta-Analysis Published on 2022-08-032022-09-11 Journal: Molecular Medicine [Category] SARS, 바이오마커, 유전자 메커니즘, 치료기술, [키워드] Accuracy acute respiratory illness acute respiratory illnesses Analysis applied ARI bioinformatics Biomarker Blood Cell cell cycle Characteristics Combination complementary controls COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patients COVID-19 sample cross cytokine cytokine production Data integration dataset Defense detect diagnose diagnostic diagnostic biomarker Diagnostic biomarkers Diseases eight enhancement feature gene expression profile Gene ontology HCs healthy control healthy controls Host host gene host response identifying Immune cell improvement Improvements independent indicated induce Infection Inflammatory interferon introduced lack machine learning algorithm Machine learning algorithms marker Meta-analysis nasopharyngeal Nasopharyngeal swab Ontology Pathogenesis pathway pathway enrichment patients with COVID-19 proportion Random forest respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis selected swab sample System Systems biology Transcriptome upregulation Viral virus Whole blood [DOI] 10.1186/s10020-022-00513-5 PMC 바로가기 [Article Type] Meta-Analysis
Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particlesOmicron 돌연변이는 SARS-CoV-2 바이러스 유사 입자의 감염성을 높이고 항체 중화를 감소시킵니다.Article Published on 2022-08-022022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Antibody neutralization Antisera assembly B.1 B.1 lineage B.1.1 bebtelovimab Casirivimab Cell cell entry change convalescent sera coronavirus COVID-19 Delta detectable detrimental dose Effect Efficacy Efficiency eight eight subject elicited ENhance examined Imdevimab individual Johnson & Johnson Johnson & Johnson luciferase Moderna monoclonal antibodies monoclonal antibody Mutation N proteins neutralization neutralization activity neutralization titer Neutralizing antibodies neutralizing antibody omicron Omicron variant Patient Pfizer Pfizer/BioNTech Prevent property reduce reduced respiratory resulting robust SARS-CoV-2 SARS-CoV-2 variant sequence sera severe acute respiratory syndrome Coronavirus Spike protein Spread structural protein structural proteins subjects survivor Vaccine Vaccines variant variants Viral viral infectivity Virus-like particle virus-like particles VLP VLPs [DOI] 10.1073/pnas.2200592119 PMC 바로가기 [Article Type] Article
Predictive performance and clinical application of COV50, a urinary proteomic biomarker in early COVID-19 infection: a prospective multicentre cohort studyResearch article Published on 2022-08-012022-10-05 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 진단, [키워드] 95% CI Accuracy adjusted age Analysis AUC baseline Biomarker BMI capillary electrophoresis Care characteristic cohort study Comorbidities country COVID-19 dataset death died Disease progression eight Euro European country finding France funding Germany Greece high risk hospital hospitalisation Infection interim analysis less Logistic regression marker Markov chain Mild-to-moderate Ministry of Health Mortality multicentre North Odds ratio outcomes participant Participants PCR-confirmed PCR-confirmed COVID-19 peptide pilot study Poland predicted Predictive Probability progression proteomic recruited reducing reduction resulting risk SARS-CoV-2 SARS-CoV-2 pandemic Sex Spain threshold Treatment was used WHO [DOI] 10.1016/S2589-7500(22)00150-9 [Article Type] Research article
Circulating tumor DNA to guide rechallenge with panitumumab in metastatic colorectal cancer: the phase 2 CHRONOS trial Research Published on 2022-08-012022-10-05 Journal: Nature Medicine [Category] 바이오마커, 변종, 임상, [키워드] antibodies approved biopsy blockade Blood BRAF carried circulating clinical trial Colorectal cancer disease DNA Efficacy EGFR eight Endpoint enrolled EudraCT growth factor monoclonal antibody mutant alleles Mutation Open-label Patient patients primary endpoint randomized trial RAS receptor regimen responses restrict secondary single-arm phase 2 Standard-of-care subsequent survival therapy Tolerability Treatment Trial Tumor were excluded wild-type Withdrawal [DOI] 10.1038/s41591-022-01886-0 [Article Type] Research
The lessons learned working in diagnostic and therapeutic radiography departments through the COVID-19 pandemic in Northern Ireland, UK. What can we do differently the next time?Research article Published on 2022-08-012022-10-05 Journal: Radiography (London, England : 1995) [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Care COVID-19 COVID-19 pandemic declined diagnostic distribution eight flexible help illness IMPROVE infected patients Ireland Lessons learned majority mental health NHS NHS service occur occurred offered over pandemic Pandemics participant Patient physical Radiography Radiotherapy receive remuneration Result shielding Support therapeutic variant Working through a pandemic [DOI] 10.1016/j.radi.2022.07.006 [Article Type] Research article
Acute infectious supraglottitis in adult population: epidemiology, management, outcomes and predictors of airway interventionObservational Study Published on 2022-08-012022-10-05 Journal: European archives of oto-rhino-laryngology : offic [Category] 임상, [키워드] airway airway management association Characteristics cohort of patient COVID-19 pandemic diagnosed distress duration of symptom eight Epidemiology Epiglottic abscess epiglottitis Factor Hospital admission Hypersalivation identify incidence incidence rate increase in independent Intervention Intubated Logistic regression analysis management men outcome Patient predictor presenting required retrospective risk factor Risk factors severity single-center smoking stratified Supraglottitis Supraglottitis. the median the patient to define Treatment was performed women younger patient [DOI] 10.1007/s00405-022-07365-z PMC 바로가기 [Article Type] Observational Study
Serum-derived extracellular vesicles: Novel biomarkers reflecting the disease severity of COVID-19 patientsArticle Published on 2022-08-012022-11-15 Journal: Journal of Extracellular Vesicles [Category] 바이오마커, 유전자 메커니즘, [키워드] antibody biochemical Biomarker Biomarkers CD13 CD24 CD82 Cell characterized circulating Concentration correlated COVID-19 COVID-19 progression COVID-19 severity disease severity Donor driver eight EVs Extracellular extracellular vesicle Extracellular vesicles flow cytometry healthy donor identify IFCM immunological parameters Immunopathogenesis MDSC mechanism Mild mild COVID-19 patient novel Patient positively correlated proinflammatory cytokines sera serum severe COVID-19 severe COVID-19 patient severe COVID-19 patients severity of COVID-19 Sex Support the disease the healthy [DOI] 10.1002/jev2.12257 PMC 바로가기
Safety and tolerability of SARS-Cov-2 vaccination in patients with myasthenia gravis: A multicenter experience중증 근무력증 환자에서 SARS-Cov-2 백신 접종의 안전성 및 내약성: 다기관 경험Multicenter Study Published on 2022-08-012022-09-12 Journal: European journal of neurology [Category] COVID19(2023년), SARS, 진단, [키워드] Administered Clinical characteristics collected Complication contributed COVID-19 pandemic Diagnosis dose eight enrolled Fever Frequency high risk higher risk information lack large cohort local pain mRNA COVID-19 vaccines multicenter myasthenia gravis offered Patient patients reported Safety SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine serological severe COVID-19 Side effect significantly higher Spontaneous subgroups subject Support Symptom Tolerability tyrosine vaccination Vaccine vaccine dose Vaccine hesitancy were assessed worsened worsening [DOI] 10.1111/ene.15348 PMC 바로가기 [Article Type] Multicenter Study