enrichment – Page 9 – Communicable Diseases Research

The analysis on the human protein domain targets and host-like interacting motifs for the MERS-CoV and SARS-CoV/CoV-2 infers the molecular mimicry of coronavirus

Research Article

Published on 2021-02-172022-10-28
Journal: PLoS ONE [Category] COVID-19, MERS,

Drugs, Metabolites, and Lung Accumulating Small Lysosomotropic Molecules: Multiple Targeting Impedes SARS-CoV-2 Infection and Progress to COVID-19

약물, 대사 산물 및 폐 축적 작은 Lysosomotropic 분자: 다중 표적은 SARS-CoV-2 감염 및 COVID-19로의 진행을 방해합니다

Hypothesis

Published on 2021-02-112022-09-10
Journal: International Journal of Molecular Sciences [Category] MERS, 신약개발, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect approved drug approved drugs Bacterial biological characteristic candidate cathepsin cathepsin L cathepsin L-dependent characteristic Chloroquine compounds condition coronavirus coronavirus disease COVID-19 CRS cytokine Cytokine release syndrome Cytokine storm disease drug Drug repurposing drugs Effects eligibility criteria endothelial enrichment heterogeneous group host cells hydroxy Hypothesis IL-6 Inflammatory intrinsic lysosomal enzyme lysosomal enzymes lysosome Lysosomes lysosomotropism metabolite metabolites Multiple OTC pandemic Patient pharmacological profile Progress Prophylaxis pulmonary tissue pulmonary tissue accumulation receiving respiratory SARS-CoV-2 SARS-COV-2 infection second messengers severe acute respiratory syndrome Coronavirus Small molecules Stress stress response systemic inflammation targeting targets tissue transition Treatment triggered Viral viral entry viral host cell entry viral infections
[DOI] 10.3390/ijms22041797 PMC 바로가기 [Article Type] Hypothesis

Depicting SARS-CoV-2 faecal viral activity in association with gut microbiota composition in patients with COVID-19

COVID-19 환자의 장내 미생물 구성과 관련된 SARS-CoV-2 대변 바이러스 활동 묘사

Observational Study

Published on 2021-02-012022-09-11
Journal: Gut [Category] SARS, 임상, 치료기술,

[키워드] absence active viral infection acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alteration Amino acid amino acid biosynthesis association Bacteria bacterial specy Bacteroide carbohydrate clearance clearance of SARS-CoV-2 coronavirus Coverage de novo density diagnostic diagnostic virology disease course enrichment Evidence faece Faeces fatty Fatty acid functional functional capacity GI Tract Glycolysis Gut gut inflammation gut microbiota gut microbiota composition hospitalised patient Infection Infectious disease investigated manifestation Manifestations metabolism metagenome metagenomic sequencing Microbiome microbiome composition microbiota nucleotide Opportunistic Pathogens Pathogens Patient patients with COVID-19 performed pilot study producing provide quantified respiratory respiratory infection Respiratory samples RNA SARS-CoV-2 SARS-CoV-2 genome Sequencing sequencing coverage Seven severe acute respiratory syndrome Coronavirus signature Stool Streptococcus the SARS-CoV-2 genome transcriptional activity Viral viral extraction viral infection Viral RNA virus with COVID-19
[DOI] 10.1136/gutjnl-2020-322294 PMC 바로가기 [Article Type] Observational Study

Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8 + T cells

Research Articles

Published on 2021-01-212022-10-28
Journal: Science Immunology [Category] COVID-19,

Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 infection induces dysregulation of immunity: in silico gene expression analysis

Research Paper

Published on 2021-01-012022-10-29
Journal: International Journal of Medical Sciences [Category] COVID-19, MERS,

[키워드] A549 ACE2 acute respiratory distress acute respiratory syndrome alteration Analysis angiotensin-converting enzyme 2 annotation applied approach bioinformatics caused cells clinical manifestation complement contribute controls coronavirus CoV COVID-19 CoVs current diagnose disease distress dysregulation effective enrichment epithelial exacerbate Gene Expression Gene ontology gene signature Genetic host cell immune system in silico induce Infection Ingenuity Pathway Analysis interferon kill Lung epithelial cells medication NHBE overexpression pandemic pathogenic coronavirus pathway Pathways performed receptor signaling Research response RNA-sequencing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected cell severely ill patients syndrome target upregulated gene Venn diagram Visualization were infected
[DOI] 10.7150/ijms.52256 PMC 바로가기 [Article Type] Research Paper

ACE2 Interaction Networks in COVID-19: A Physiological Framework for Prediction of Outcome in Patients with Cardiovascular Risk Factors

Article

Published on 2020-11-212022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

[키워드] ACE-2 ACE2 ACE2 expression acute respiratory syndrome adverse outcome affected AGT Algorithm Alzheimer’s disease amyloid Analysis analyzed angiotensinogen app approach Beta CALM1 calmodulin cardiovascular cardiovascular disease cardiovascular risk factors cardiovascular systems catalase CAV1 CCL2 changes in co-expression Complete component confidence level congestive heart failure coronavirus coronavirus disease COVID-19 COVID19 CVD datasets described Diagnosis disease Diseases DPP4 EGFR enrichment enrichment analysis expression data Factor Fibronectin FN1 framework functional Gene Expression groups heart tissue HSP90AA1 hypertensive identify Importance Infection information Interaction investigated lung MAST2 microRNA miR miRNA nervous system network non-insulin-dependent diabete obesity outcome Patient peptidase performed predicted prediction Protein protein-protein interaction provide regulate relative responsible risk SARS-CoV-2 SARS-COV-2 infection Signaling signaling pathway Symptoms TFRC therapeutic target tissue expression TP53 was performed
[DOI] 10.3390/jcm9113743 PMC 바로가기 [Article Type] Article

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

생명을 위협하는 COVID-19 환자에서 I형 IFN 면역의 선천적 오류

Research Article

Published on 2020-10-232022-08-13
Journal: Science (New York, N.y.) [Category] MERS, SARS, 유전자 메커니즘,

[키워드] a minor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration Affect affecting age amplification amplification pathway Asymptomatic autoantibodies autoantibody autoantibody system autosomal-dominant autosomal-recessive Beck biochemically BOLD candidate gene approach caused cellular clinical Clinical course Clinical outcome clinical variability complete penetrance complex component components core gene core genes coronavirus coronavirus disease Coronavirus disease 2019 Course COVID COVID Human Genetic Effort COVID-19 COVID-19 patient COVID-19 pneumonia Critical Critical disease cytokine Cytokines damage dampen deficiencies deficiency defined Deleterious dendritic cell dendritic cells determine Diseases double-stranded RNA eight enrichment epidemiological studies Exome fibroblast fibroblasts Genes genes encoding genetic defect genetic defects genetics Genome genomics study had milder phenotype healthy individuals highest Hospitalized Human human fibroblasts with mutations Hypothesis identify IFN IFN response IFN-α2 IFNAR1 IFNAR1 deficiency IFNAR2 IFNs IKBKG immune system Immunity immunological in healthy individuals in some in vitro Inborn error Inborn errors incomplete penetrance individual induction pathway Infection infection with SARS-CoV-2 Infectious diseases Influenza influenza pneumonia Influenza virus inheritance interferon interferon regulatory factor interferon regulatory factor 7 interferons interferons (IFNs) involved IRF3 IRF7 IRF9 lack life-threatening likelihood loci LOF loss-of-function male mechanism Medical conditions minor minor allele frequency molecular molecule molecules monogenic inborn error monogenic inborn errors mutated Mutation NEMO NEMO/IKBKG Neutralizing nonsynonymous variant other variants outcome pathogen pathogen-induced inflammation pathway Patient patients Perspective plasmacytoid dendritic cells pLOF Pneumonia predicted Prevent produced rare variant Rare variants Regulation respiratory reveal risk risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection in vitro Science selected sequenced severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe coronavirus disease severe COVID-19 Severe COVID-19 pneumonia severe disease Severe infection silent infection Stat1 STAT2 subject susceptible TBK1 tested Therapeutic benefit this system TICAM1 TICAM1/TRIF tissue TLR3 Toll-like receptor Toll-like receptor 3 TRAF3 TRIF Type type I Type I IFN type I IFNs type I interferon UNC93B1 underlie variant variants Viral Viral illness viral illnesses
[DOI] 10.1126/science.abd4570 PMC 바로가기 [Article Type] Research Article

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

생명을 위협하는 COVID-19 환자에서 I형 IFN에 대한 자가항체

Research Article

Published on 2020-10-232022-08-13
Journal: Science (New York, N.y.) [Category] MERS, SARS, 유전자 메커니즘,

[키워드] Activation acute disease acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Affect affected age antiviral immunity Asymptomatic auto-Ab auto-Abs autoantibodies autoantibody autoantibody system Autoimmune Autoimmunity B cell Beck binding can not candidate gene approach cause causes Clinical course clinical phenotype clinical phenotypes clinical variability collected complex component components Concentration conditions coronavirus coronavirus disease Coronavirus disease 2019 correlated Course COVID-19 COVID-19 pandemic COVID-19 patients COVID-19 pneumonia Critical Critical disease cytokine Cytokines damage dampen death determine disease Diseases downstream enrichment enrolment epidemiological excess explain Genes genetics genomics study had milder phenotype healthy control healthy individual healthy individuals highest Human Hypothesis identify IFN IFN response IFN-stimulated genes IFN-α IFN-α/β IFN-α2 IFN-β IFN-γ IFNAR IFNs IgG IL-17A IL-6 immune system Immunity Immunoglobulin Immunoglobulin G immunological impair impairing in healthy individuals in vitro Inborn errors increase in individual infected with SARS-CoV-2 Infection Infectious diseases interferon interferon regulatory factor interferon-γ interferons interferons (IFNs) interleukin interleukin-6 intrinsic involved IRF ISGs lack life-threatening life-threatening coronavirus disease likelihood male mechanism men mild SARS-CoV-2 infection morbidity morbidity and mortality mucocutaneous candidiasis Mutation mycobacterial disease neutralize Neutralizing outcomes pandemic pathogen pathogen-induced inflammation pathway Patient patients patients hospitalized Perspective phosphorylated Plasmapheresis Pneumonia Prevent pSTAT receptor receptors Regulation respiratory rising risk risk factor SARS-CoV-2 SARS-COV-2 infection Science searched serum IFN-α level severe acute respiratory syndrome Coronavirus severe coronavirus disease severe COVID-19 Severe COVID-19 pneumonia shown silent infection staphylococcal susceptible tested the patient this system TLR Toll-like receptor Transcription Treatment trials type 1 interferon type 1 interferons type I Type I IFN type I IFNs underlie undetectable Vaccine Viral viral infections viral respiratory diseases while women
[DOI] 10.1126/science.abd4585 PMC 바로가기 [Article Type] Research Article

Similarity between mutation spectra in hypermutated genomes of rubella virus and in SARS-CoV-2 genomes accumulated during the COVID-19 pandemic

풍진 바이러스의 과돌연변이된 게놈과 COVID-19 전염병 동안 축적된 SARS-CoV-2 게놈의 돌연변이 스펙트럼 간의 유사성

Research Article

Published on 2020-10-022022-08-13
Journal: PLoS ONE [Category] MERS, SARS, 유전자 메커니즘,

[키워드] accumulated accumulation Analysis APOBEC cytidine deaminase change characteristic COVID-19 pandemic cytidine Cytidine deaminase dataset Each enrichment event genomes genomic RNA human population hypermutated genome hypermutated genomes hypermutation individual isolate lead motif Mutation mutation mechanism mutation mechanisms mutational spectrum new SARS-CoV-2 pathological condition positive predicted preference Propagation reported RNA secondary structure RNA virus rubella rubella vaccine rubella vaccine virus rubella virus SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 mutation SARS-CoV-2 viruses SARS-CoV2 secondary structure sequenced similarity single base substitution single base substitutions single subject strand genomic RNA subclass substitutions suggested the SARS-CoV-2 virus virus isolate viruses
[DOI] 10.1371/journal.pone.0237689 PMC 바로가기 [Article Type] Research Article

Therapeutic mechanism of Toujie Quwen granules in COVID-19 based on network pharmacology

Research

Published on 2020-09-242022-10-28
Journal: BioData Mining [Category] COVID-19,

[키워드] ACE ACE2 Analysis approach BCL2L1 BDKRB2 benefit biological function cascades CASP3 Chinese clusterProfiler package co-expressed Coagulation Compound coronavirus disease COVID-19 cytoHubba Cytoscape drug-likeness effective effort EGFR enrichment enrichment analysis Epidemic ESR1 FPR2 function Granule help HIF-1 Immunity Inflammatory Inflammatory response ingredient kaempferol knowledge Luteolin MAPK signaling mechanism mediated immunity Mild MPO network pharmacology neutrophil Ontology oral bioavailability pathway patients performed pharmacological mechanism PI3K-Akt signaling potential mechanism potential therapeutic target potential therapeutic targets predict progression protein-protein interaction quercetin R software Regulation Result screenings signaling pathway signaling pathways STAT3 Stress suggested Symptoms target TCMSP the disease therapeutic Topology Toujie Quwen granule Treatment treatment for COVID-19 Venn diagram was performed was used were used
[DOI] 10.1186/s13040-020-00225-8 PMC 바로가기 [Article Type] Research