Antibody-Dependent Enhancement of SARS-CoV-2 Infection of Human Immune Cells: In Vitro Assessment Provides Insight in COVID-19 PathogenesisArticle Published on 2021-12-112022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] ADE ADE effect antibody Antibody-dependent enhancement assessment association collected condition conducted convalescent serum COVID-19 COVID-19 pathogenesis COVID-19 patients demonstrated Dilution dysregulated enhancement exacerbate excessive immune response Express Factor FcγR Gene Expression Host Human immune immune cells in vitro Infection insight Macrophage medium Monocytes Neutralizing titer patients positively correlated primary B cells provide raise RBD SARS-CoV-2 SARS-COV-2 infection serum sample severe lung pathology Severe patient Severity of disease viral antibody viral gene with COVID-19 [DOI] 10.3390/v13122483 PMC 바로가기 [Article Type] Article
E-learning readiness and perceived stress among the university students of Bangladesh during COVID-19: a countrywide cross-sectional studyResearch Article Published on 2021-12-102022-10-28 Journal: Annals of Medicine [Category] Coronavirus, SARS, [키워드] association coping strategies COVID-19 COVID-19 pandemic cross-sectional e-learning ENhance enrolled exacerbate Factors highest indicated moderate Perceived stress platform Policymaking problem readiness reported Result significantly significantly higher Sociodemographic Stress suffered [DOI] 10.1080/07853890.2021.2009908 PMC 바로가기 [Article Type] Research Article
The military as a neglected pathogen transmitter, from the nineteenth century to COVID-19: a systematic reviewReview Published on 2021-12-102022-10-31 Journal: Global Health Research and Policy [Category] COVID-19, SARS, [키워드] affected Analysis Biological conditions Contaminated country COVID-19 Critical database described disease Diseases distribution driving Evidence exacerbate feature Frequency generate global public health Global public health policy groups Health health systems impacted impair inclusion criteria increasingly Infectious disease information living condition mechanism mechanisms Military as transmission vector Military civilian transmission of infectious disease outbreak Pandemics pathogen performed poor compliance populations provided public health reported researcher Result risk searched selected supplementary material systematic review Transmission unhygienic unique vaccination while [DOI] 10.1186/s41256-021-00232-0 PMC 바로가기 [Article Type] Review
Substitution of Nonpharmacologic Therapy With Opioid Prescribing for Pain During the COVID-19 PandemicObservational Study Published on 2021-12-102022-10-04 Journal: JAMA Network Open [Category] SARS, 임상, [키워드] 95% CI absence accompanied affected age Analysis Asian back pain black Care complementary condition COVID-19 COVID-19 pandemic Critical cross-sectional database decrease diagnose Diagnosis doses enrolled Epidemic evaluated Evidence exacerbate finding Hispanic imperative implication Importance increase in individual level joint less limb management mean difference measure Neck pain objective opioid outbreak outcome Pain pandemic participant Patient physical Point Practitioner prescribing Prevent proportion receive receiving Relevance replacing Result retrospective risk setting Substitution substitutions therapy transition Treatment viral spread was performed white [DOI] 10.1001/jamanetworkopen.2021.38453 PMC 바로가기 [Article Type] Observational Study
The Effect of Pandemic Movement Restriction Policies on Children’s Physical Fitness, Activity, Screen Time, and SleepPublic Health Published on 2021-12-062022-10-31 Journal: Frontiers in Public Health [Category] Coronavirus, MERS, SARS, [키워드] 24-hour movement behavior activity age alteration both sexes cardiorespiratory fitness changes in children conducted Control Course COVID-19 COVID-19 pandemic demonstrated determine Effect environmental epidemiology exacerbate female First wave fitness initial initiated interaction effect Isolation less lockdown movement musculoskeletal strength outcome pandemic per day phase physical physical activity Policy questionnaire reductions in reflected repeated reported restriction Screen screen time Sex significant interaction significant main effect Sleep Tapping time translate worsening [DOI] 10.3389/fpubh.2021.785679 PMC 바로가기 [Article Type] Public Health
Association Between Nonsteroidal Antiinflammatory Drug Use and Adverse Clinical Outcomes Among Adults Hospitalized With Coronavirus 2019 in South Korea: A Nationwide Study한국에서 코로나 바이러스 2019로 입원 한 성인의 비 스테로이드 성 항염증제 약물 사용과 불리한 임상 결과 사이의 연관성 : 전국 연구Article Published on 2021-12-062022-08-31 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 치료제, [키워드] 95% CI 95% confidence interval acute renal failure acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission adults hospitalized Adverse adverse outcomes age antiinflammatory antiinflammatory drug bind cardiovascular complication cardiovascular complications caution cells CIs clinical Cohort cohort study Composite conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 test database drug enzyme exacerbate female healthcare Hospitalization In-hospital death increased risk individual intensive care intensive care unit admission Logistic regression analysis mechanical ventilation nationwide study Nonsteroidal nonsteroidal antiinflammatory drugs NSAID NSAIDS Odds ratio outcome pharmacoepidemiologic study. Primary outcome Probability renal failure respiratory SARS-CoV-2 secondary outcome Sepsis severe acute respiratory syndrome Coronavirus South South Korea Treatment upregulating Weighting while with COVID-19 [DOI] 10.1093/cid/ciaa1056 PMC 바로가기 [Article Type] Article
Humoral and Cellular Immune Responses Against Severe Acute Respiratory Syndrome Coronavirus 2 Variants and Human Coronaviruses After Single BNT162b2 Vaccination단일 BNT162b2 백신 접종 후 중증 급성 호흡기 증후군 코로나바이러스 2 변이체 및 인간 코로나바이러스에 대한 체액 및 세포 면역 반응Article Published on 2021-12-062022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against antibodies B.1.1.7 B.1.351 B.1.351 variant B.1.351 variants BNT162b2 boost cellular immunity combating contribute coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 courses COVID-19 Defense detectable Endemic endemic human coronavirus endemic human coronaviruses evade exacerbate frequencies Frequency HCoV HCoVs host cell Human humoral IgG Immunity immunization Immunoglobulin Immunoglobulin G individual Infection Neutralizing antibodies neutralizing antibody P.1 pandemic question reactive Receptor-binding domain respiratory response S protein SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 WT second vaccination severe acute respiratory syndrome Coronavirus severe disease significantly single dose single vaccination South Africa T cell T cells T-cell T-cell Response T-cell responses the receptor-binding domain the SARS-CoV-2 United Kingdom vaccination Vaccine vaccinee variants of concern VoC wild-type [DOI] 10.1093/cid/ciab555 PMC 바로가기 [Article Type] Article
Clinical and cost-effectiveness of a New psychosocial intervention to support Independence in Dementia (NIDUS-family) for family carers and people living with dementia in their own homes: a randomised controlled trialRandomized Controlled Trial Published on 2021-12-022022-10-04 Journal: Trials [Category] SARS, 임상, [키워드] Affect attainment behavioural benefit Care clinical clinical trial component Controlled COVID-19 COVID-19 pandemic Dementia demonstrated determine distress dyad evaluate the effect exacerbate facilitator Family carer Follow-up Goal Health implementation improvement include Increasing Independence initial Intervention intervention group knowledge management MOST New number offered professional Psychosocial intervention randomised randomised controlled trial receive recruitment Scaling selected Standard Stress Support supported Trial Two-arm usual care usual care alone [DOI] 10.1186/s13063-021-05851-z PMC 바로가기 [Article Type] Randomized Controlled Trial
Effect of parenteral nutrition in oxygen escalation/de-escalation in SARS-CoV-2 infected patients who are pre-intubation: A multicenter, observational studyObservational Study Published on 2021-12-012022-10-05 Journal: Clinical nutrition ESPEN [Category] SARS, 임상, [키워드] 95% CI affected age analyzed baseline Biomarker body mass index case-control study Comorbidity control group dependent on determine Effect Escalation exacerbate Gender hospital include Initiating intravenous intubation Local malaise manifestation multicenter myalgias non-invasive ventilation outcome oxygen Oxygen requirement Oxygen requirements Parenteral parenteral nutrition Patient patients Pre-intubation risk SARS-CoV-2 SARS-CoV-2 infected patient SARS-COV-2 infection SARS-CoV-2 patient significantly significantly lower Symptom variety [DOI] 10.1016/j.clnesp.2021.10.007 PMC 바로가기 [Article Type] Observational Study
SARS-CoV-2 deregulates the vascular and immune functions of brain pericytes via Spike proteinSARS-CoV-2는 스파이크 단백질을 통해 뇌 혈관주위세포의 면역 기능과 면역 기능을 완화합니다.Article Published on 2021-12-012022-09-11 Journal: Neurobiology of disease [Category] SARS, 유전자 메커니즘, [키워드] accompanied accumulated ACE2 ACE2 expression acquisition Actin Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 assays binding Brain brain damage calcium cause caused cerebrovascular cerebrovascular disorders change characterized collagen Comorbidity contractile coronavirus disease coronavirus disease 19 Coronavirus-2 COVID-19 COVID-19 pathogenesis Cytokines deregulated develop disorder enzyme exacerbate Express expressing expression Fibronectin fluctuations function functional homolog host cell host cells human ACE2 Human brain hypoxia immune Immune cell immune function immune reaction impair infect infection with SARS-CoV-2 Inflammation inhibitory intranasal involved lipid peroxidation locus Macrophage mechanism mechanisms mice MIF Migration morphology Myofibrogenic transition nasal mucosa Neurological disorder Neurological disorders Neurovascular Neurovascular interface NF-κB NOTCH3 nuclear oxidative pericyte pericytes phenotypic pro-inflammatory cytokine pro-inflammatory cytokines promoted Protein Proteins provide reached reactivity receptor recognize Regulatory Respiratory illness S protein SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 S protein. Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus shown signaling pathway spike Stress therapeutic interventions transgenic mice translated transmembrane triggered Vascular viral spike was increased [DOI] 10.1016/j.nbd.2021.105561 PMC 바로가기 [Article Type] Article