Baseline serum exosome-derived miRNAs predict HBeAg seroconversion in chronic hepatitis B patients treated with peginterferonArticle Published on 2021-08-012023-06-13 Journal: Journal of medical virology [Category] B형 간염, [키워드] Chronic Hepatitis B Exosome miR-194-5p miR-22-3p peginterferon [DOI] 10.1002/jmv.26916
Diverse Effects of Exosomes on COVID-19: A Perspective of Progress From Transmission to Therapeutic DevelopmentsCovid-19에 대한 엑소 좀의 다양한 효과 : 전염에서 치료 적 발전으로의 진보의 관점Review Published on 2021-07-282022-08-31 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus administration Anti-viral antiviral drug antiviral drugs approach causative agent cells combating Combination communication coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cytokine storm Defense develop development Diagnosis disease Effect ENhance Exosome Exosomes global pandemic Host immunomodulatory infected cells Infection intercellular Intervention lung injuries mesenchymal stem cell Mesenchymal stem cells mitochondrial Mitochondrial function modulate MSCs new strain new strain of coronavirus Numerous pathway Pathways Patient Perspective produced Progress promote reduce respiratory respiratory tract SARS-CoV-2 SARS-COV-2 infection secreted secretion severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 similarity Spread stem cell structures suppress the cytokine storm therapeutic agents Therapeutic benefit therapeutic benefits Therapeutics Therapies Transmission Treatment Treatment strategies treatment strategy uninfected cells Vaccine development Vaccines virus virus-infected cell virus-infected cells viruses with COVID-19 [DOI] 10.3389/fimmu.2021.716407 PMC 바로가기 [Article Type] Review
Combination of mesenchymal stem cells and nicorandil: an emerging therapeutic challenge against COVID-19 infection-induced multiple organ dysfunctionCommentary Published on 2021-07-152022-10-29 Journal: Stem Cell Research & Therapy [Category] COVID-19, SARS, [키워드] activity administration Apoptosis assumed attenuate Cell cell injury Compound COVID-19 cytokine expression death Effect Exosome homing Immune cell IMPROVE Inflammation Inflammatory response inhibiting lung Mesenchymal stem cells microenvironment modulate MSC multi-organ failure multiple organ dysfunction Nicorandil Nitrate pandemic paracrine pharmacological potassium channel Prevent protective effect reactive oxygen specy SARS-COV-2 infection stem cell survival therapeutic Treatment [DOI] 10.1186/s13287-021-02482-8 PMC 바로가기 [Article Type] Commentary
Exosome-Based Vaccines: History, Current State, and Clinical Trials엑소좀 기반 백신: 역사, 현재 상태 및 임상 시험Review Published on 2021-07-142022-09-11 Journal: Frontiers in Immunology [Category] SARS, 임상, [키워드] Biological functions Cancer cancer cell Cancer cells cell proliferation cell type cell types clinical clinical trial conducted coronavirus coronavirus disease current dendritic cell dendritic cells Diseases Evidence EVs example Exosome Exosomes Extracellular vesicles extracellular vesicles (EV) history immune response immune responses immunization implicated induce Infectious diseases Inflammation management mechanism mediation molecules Pathogenesis Perspective recent released shown state target Therapeutic strategies Therapeutics Treatment Usage vaccination Vaccine Vaccines Vesicle [DOI] 10.3389/fimmu.2021.711565 PMC 바로가기 [Article Type] Review
Exosomes mediate horizontal transmission of viral pathogens from insect vectors to plant phloemArticle Published on 2021-07-022023-08-30 Journal: eLife [Category] E형 간염, [키워드] Exosome insect vectors multivesicular bodies plant phloem salivary glands Viral transmission virus [DOI] 10.7554/eLife.64603 PMC 바로가기
Serum exosomal long noncoding RNA nuclear-enriched abundant transcript 1 predicts 90-day mortality in acute-on-chronic hepatitis B liver failureArticle Published on 2021-07-012023-06-12 Journal: Expert review of clinical immunology [Category] B형 간염, [키워드] Biomarker Exosome lncRNA NEAT1 Prognosis [DOI] 10.1080/1744666X.2021.1933442
Emerging Evidence for Pleiotropism of EosinophilsReview Published on 2021-06-302022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome allergies Asthma Bacteria biologic treatment Blood Bone marrow complex coronavirus SARS-CoV-2 described detrimental Developing disease disorder effective response effector enzymatic activity eosinophil eosinophil extracellular traps eosinophils esophagitis example Exosome extracellular DNA Factors function gastrointestinal tract GM-CSF granulocyte homeostasis human physiology IL-5 immune immune defense immune responses Immunity involved liver lung Macrophage mammary mechanism monoclonal antibody organ organs parasites Pathologies pathophysiologic pleiotropic Pleiotropism regulatory cell respond Skeletal muscle specific treatment sub-phenotypes surface receptors sustained these cell tissue homeostasis Treatment viral pathogen [DOI] 10.3390/ijms22137075 PMC 바로가기 [Article Type] Review
A multi-omics investigation of the composition and function of extracellular vesicles along the temporal trajectory of COVID-19 Research Published on 2021-06-222022-10-05 Journal: Nature metabolism [Category] SARS, 유전자 메커니즘, 치료기술, 치료법, [키워드] Alter alveolar epithelial cells Analysis cells cellular changes in convalescent COVID-19 distal dysregulated dysregulation Effect Endocytic pathway eukaryotic translation Exosome Extracellular extracellular vesicle fraction hepatocytes highlight Hyperinflammatory hyperinflammatory phase in vitro induce Infection Isolation lipid metabolism liver membrane methodology multivesicular body Notch Patient plasma presymptomatic primary site proteomic released resource retrograde transport Stage trajectory transcriptional response Vesicle [DOI] 10.1038/s42255-021-00425-4 [Article Type] Research
C-type lectins and extracellular vesicles in virus-induced NETosisReview Published on 2021-06-112022-10-29 Journal: Journal of Biomedical Science [Category] COVID-19, MERS, SARS, [키워드] activate acute respiratory syndrome acute viral infections attenuate blockade C-type lectin C-type lectin receptor (CLR) caused CLEC10A CLEC2 CLEC5A Coagulopathy contribute Coronavirus-2 COVID-19 Cytokine storm danger signals DC-SIGN dengue virus Dengue virus (DV) disease severity ENhance EVs exacerbate Exosome Exosome (EXO) extracellular vesicle Extracellular vesicle (EV) facilitate glycan Inflammation inflammatory reactions intercellular Japanese L-SIGN microvesicle Microvesicle (MV) NET NETosis NETs neuronal Neutrophil extracellular trap organ Pathogenesis Patient pattern recognition receptor Platelet receptor reported responsible SARS-CoV-2 shown spleen stimulate TLR TLR2 tyrosine virus [DOI] 10.1186/s12929-021-00741-7 PMC 바로가기 [Article Type] Review
Exosomes contribution in COVID-19 patients’ treatmentCommentary Published on 2021-05-312022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, SARS, [키워드] acute respiratory syndrome adipocyte adipose derived stem cells caused Cell clinical study coronavirus coronavirus disease COVID-19 COVID-19 infection COVID-19 patients derivative effective endothelial Exosome Exosomes Factors growth growth factor human diseases immunomodulatory activity Inflammation insulin Mesenchymal stem cells morbidity and mortality MSC MSCs NGF patient safety potential therapeutic agent public health recent SARS-CoV-2 secretion stem cell the patient therapeutic option therapeutic potential therapy Treatment Vascular VEGF [DOI] 10.1186/s12967-021-02884-5 PMC 바로가기 [Article Type] Commentary