Integrated hepatic single-cell RNA sequencing and untargeted metabolomics reveals the immune and metabolic modulation of Qing-Fei-Pai-Du decoction in mice with coronavirus-induced pneumonia통합 된 간 단일 세포 RNA 시퀀싱 및 표적화되지 않은 대사체는 코로나 바이러스-유도 폐렴과 마우스에서 Qing-Fei-Pai-Du 달인의 면역 및 대사 조절을 보여준다.Article Published on 2022-03-012022-08-31 Journal: Phytomedicine : international journal of phytother [Category] 유전자 메커니즘, 치료제, [키워드] alteration Analysis attenuate B cells BALB/c mice best CD4 CD8 clinically Cold Cold-damp environment Combination Control control group coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus pneumonia COVID-19 patients Cytokines damp environment disease disease-associated exposure to Gene Expression HCoV HCoV-229E human coronavirus IFN-γ IL-6 immune immune function Immunity immunological IMPROVE indicated infecting Infection Inflammation Inflammatory cytokine Inflammatory cytokines knowledge Liver injury liver tissue Lymphocytes mechanism mechanism of action metabolic function metabolism metabolomics mice Model modulate modulation mouse model Mouse models performed Peripheral blood peripheral blood lymphocyte peripheral blood lymphocytes Pneumonia profile purine Qing-Fei-Pai-Du decoction reduce regulated Regulatory reveal RNA RNA sequencing significantly significantly increased Single-cell RNA sequencing status T cells TCM therapy TNF-α transcriptional treat treated Treatment Untargeted metabolomics [DOI] 10.1016/j.phymed.2021.153922 PMC 바로가기 [Article Type] Article
A Methodological Approach to Use Contextual Factors for Epidemiological Studies on Chronic Exposure to Air Pollution and COVID-19 in ItalyArticle Published on 2022-03-012022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, MERS, SARS, [키워드] addressed Air pollution Analysis analyzed anthropogenic approach association associations carried Characteristics chronic collected Community component components contextual factors correlated correlation COVID-19 COVID-19 disease COVID-19 incidence COVID-19 pathology data synthesis techniques dimension dimensions distribution ecological epidemiological studies Epidemiology explained exposure to Factor FIVE Frame Health healthcare identify incidence information initial ISTAT Italian Italian population Italy Ministry of Health Mortality National National Health Service NHS offer PCA Pollution predictors Principal component principal component analysis (PCA) proliferation provide reducing Repository severity spatial information Variability variable [DOI] 10.3390/ijerph19052859 PMC 바로가기 [Article Type] Article
How can biophotonics help dentistry to avoid or minimize cross infection by SARS-CoV-2?생체 광자학은 치과에서 SARS-CoV-2에 의한 교차 감염을 피하거나 최소화하는 데 어떻게 도움이 됩니까?Review Published on 2022-03-012022-09-11 Journal: Photodiagnosis and photodynamic therapy [Category] SARS, 치료기술, [키워드] aerosol aerosol-generating procedures antimicrobial Antimicrobial blue light Antimicrobial photodynamic therapy approach approaches benefit biofilm Biology Biophotonics Blood body fluids caries center Combination contribute Control COVID-19 COVID-19 dentistry biosafety COVID-19 infection COVID-19 pandemic cross Cross-infection defined dental Dental caries dentistry disease disease control droplet droplets Early detection Endodontic Endodontic treatment Endodontics evaluated Evidence exposure to Face-to-face communication facilitate general term Google handling help increased risk Infection Interaction invasive Laser Laser therapy less literature review offer oral Oral decontamination Oral soft tissues periodontal periodontal disease Periodontics Photobiomodulation photodynamic therapy photonics physical prevention promote reduce retrieved risk Saliva SARS-CoV-2 SciELO tissues transmitted UVC decontamination. variety virus was performed [DOI] 10.1016/j.pdpdt.2021.102682 PMC 바로가기 [Article Type] Review
A systematic review and meta-analysis of the accuracy of SARS-COV-2 IGM and IGG tests in individuals with COVID-19COVID-19 환자를 대상으로 한 SARS-COV-2 IGM 및 IGG 검사의 정확도에 대한 체계적인 검토 및 메타 분석Review Published on 2022-03-012022-09-11 Journal: Journal of Clinical Virology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Accuracy antibody AUC Chain Reaction Cochrane Library complementary confirmation contribute database databases diagnostic Diagnostic meta-analysis diagnostic testing eligible evaluate exposure to high accuracy Humoral response humoral responses IgG antibodies IgM and IgG Immunoglobulin immunoglobulins immunosurveillance index individuals with COVID-19 Infection literature Meta-analysis nucleic acid Nursing observational studies observational study polymerase chain polymerase chain reaction Research reverse transcriptase Reverse transcriptase polymerase chain reaction RT-PCR SARS-CoV-2 SARS-COV-2 infection sensitivity Sensitivity and specificity serology specificity systematic review the disease transcriptase utility Viral viral nucleic acid virus was performed Web of Science [DOI] 10.1016/j.jcv.2022.105121 PMC 바로가기 [Article Type] Review
Limited Recognition of Highly Conserved Regions of SARS-CoV-2SARS-CoV-2의 고도로 보존된 지역에 대한 제한된 인식Research Article Published on 2022-02-232022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antigen-specific CD8+ T cells approach CD8 circulating Community Comparative conservation conserved conserved regions convalescent coronavirus coronavirus disease coronavirus strains COVID-19 Critical cross-protective immunity cross-reactive disease encoded protein epitope epitope mapping Epitopes exposure to FIVE Frame generate immune protection immune response immune responses immunodominant implication individuals less likelihood Limited memory memory T cells nucleocapsid observation Open reading frame ORF1 ORF1ab overcome pandemic Participants polyprotein Preexisting immunity protective role Protein Recognition Region required respiratory robust SARS-CoV-2 SARS-CoV-2 infected cells seasonal coronaviruses Sequence analysis severe acute respiratory syndrome Coronavirus severe COVID-19 severe disease T cell T cell response T cell responses T cells T-cell epitope T-cell epitopes T-cell Response T-cell responses understanding unlikely vaccination volunteers [DOI] 10.1128/spectrum.02780-21 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 outbreak in a Canadian suburban tertiary hospital necessitating full facility closure: a descriptive observational study전체 시설 폐쇄가 필요한 캐나다 교외의 3차 병원에서 발생한 SARS-CoV-2 발생: 기술 관찰 연구Article Published on 2022-02-222022-09-11 Journal: CMAJ open [Category] COVID19(2023년), SARS, 치료기술, [키워드] age approaches Asymptomatic Cluster Clusters Community community hospital complex composed conducted Contact tracing contributed Critical care death Dementia demographics description determine Diagnosis driven by Edmonton equipment exposure to female Health help hospital Hospital staff Infection Inpatients Intervention MOST occupational health one patient outbreak outcome Patient patients precautions Premature Prevalence Protective public health required retrospective SARS-CoV-2 SARS-COV-2 infection Transmission variable were recorded [DOI] 10.9778/cmajo.20210064 PMC 바로가기 [Article Type] Article
Centrifugal Microfluidic Method for Enrichment and Enzymatic Extraction of Severe Acute Respiratory Syndrome Coronavirus 2 RNA중증 급성 호흡기 증후군 코로나바이러스 2 RNA의 농축 및 효소 추출을 위한 원심 미세 유체 방법Article Published on 2022-02-222022-09-11 Journal: Analytical Chemistry [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplification analyst analyzed applicability buffer capsid Centrifugal Chain Reaction comparable complex controls coronavirus coronavirus 2 demonstrated development Diagnosis diagnostics downstream effective ENhance enrichment exposure to extraction imperative in viral inhibit Intervention Isolation lysed nasopharyngeal Nasopharyngeal swab nucleic acid nucleic acids Particle pathogen detection pathogenic Pathogens platform polymerase chain polymerase chain reaction positive purification real-time reverse transcriptase real-time RT-PCR removal respiratory reverse transcriptase Reverse transcriptase polymerase chain reaction RNA RNA extraction robust RT-PCR Saliva Sample SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 RNA SARS-CoV-2 virion severe acute respiratory syndrome Coronavirus Surveillance Transmission Transport media Treatment tube Viral RNA viral transport media virus [DOI] 10.1021/acs.analchem.1c05215 PMC 바로가기 [Article Type] Article
A Comparative Analysis of In-Hospital Mortality per Disease Groups in Germany Before and During the COVID-19 Pandemic From 2016 to 2020Research Published on 2022-02-152022-10-29 Journal: JAMA Network Open [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] 95% CI age Analysis analyzed association calculated Care classification Cohort Comparative consecutive sample COVID-19 COVID-19 pandemic Critical cross-sectional database death deaths defined diagnoses discharge disease examined exclusion exposure exposure to finding Germany group Health Helio hospital Hospital admission hospital admission rate Hospitalization ICD-10 implication Importance In-hospital In-hospital death in-hospital mortality in-hospital mortality rate incidence increase in index individual infections Infectious disease Inpatient Inpatients investigated measure Modification Mortality mortality risk Musculoskeletal objective pandemic participant Patient patients with SARS-CoV-2 Point Poisson regression rate ratio reduction reduction in Relevance report Respiratory disease respiratory diseases Result revision SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 pandemic setting Sex spectrum of diseases subgroups tertiary care hospitals the SARS-CoV-2 viral disease women [DOI] 10.1001/jamanetworkopen.2021.48649 PMC 바로가기 [Article Type] Research
Anti-SARS-CoV-2 IgA Identifies Asymptomatic Infection in First RespondersAnti-SARS-CoV-2 IgA, 최초 응답자의 무증상 감염 식별Article Published on 2022-02-152022-09-11 Journal: The Journal of Infectious Diseases [Category] MERS, 진단, 치료법, [키워드] added anti-Nucleocapsid IgG Anti-spike anti-Spike IgG antibody Asymptomatic asymptomatic infection baseline benefit correlated COVID-19 cumulative cumulative incidence emergency medical service Epidemiology estimates exposure to First responder first responders Follow-up General population group high risk IgA IgG illness illnesses immune response Immunoglobulin immunoglobulin A IMPROVE incidence infection with SARS-CoV-2 longitudinal majority medical service police positive provided Responder retrospective risk SARS-CoV-2 SARS-COV-2 infection serologic surveys serologic test serologic tests seropositive Serosurvey Serosurveys spike IgA were assessed with COVID-19 [DOI] 10.1093/infdis/jiab524 PMC 바로가기 [Article Type] Article
Antibody Response to SARS-CoV-2 Infection and Vaccination in COVID-19-naïve and Experienced IndividualsSARS-COV-2 감염 및 COVID-19-Naïve 및 경험이 풍부한 개인의 예방 접종에 대한 항체 반응Article Published on 2022-02-102022-09-01 Journal: Viruses [Category] COVID19(2023년), Fulltext, MERS, SARS, 진단, [키워드] affected age Anti-spike antibodies antibody Antibody Response Antigen antigen exposure BNT162b2 boost co-morbidities Cohort contribute COVID-19 dose elevated exhibited exposure to Gender individual induce Infection magnitude Moderna morbidities mRNA mRNA vaccine mRNA vaccines mRNA-1273 neutralization activity neutralization titer Neutralizing Pfizer Pfizer–BioNTech response robust SARS-CoV-2 SARS-CoV-2 pandemic significant increase subject the disease understanding vaccination Vaccine vaccine dose vaccine response [DOI] 10.3390/v14020370 PMC 바로가기 [Article Type] Article