Extracellular – Page 9 – Communicable Diseases Research

SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway

Research Article

Published on 2021-12-062022-10-31
Journal: eLife [Category] COVID-19, SARS,

Mechanisms of thrombosis in ANCA-associated vasculitis

ANCA 관련 혈관염에서 혈전증의 기전

Review

Published on 2021-12-012022-09-11
Journal: Clinical Rheumatology [Category] MERS, SARS, 바이오마커, 진단, 치료기술,

[키워드] Activated neutrophils Activation anti-neutrophil cytoplasmic antibody Anti-neutrophil cytoplasmic antibody-associated vasculitis antibodies antibody antiphospholipid antibodies antiphospholipid antibody APL Blood caused circulation clotting cocaine contribute coronavirus disease Coronavirus disease 2019 COVID-19 cytoplasmic Deep vein Deep vein thrombosis described driving drug Embolism Embolism and thrombosis endothelial injury Endothelium ENhance expressing Extracellular greater homeostatic hydralazine Injury Levamisole mechanism Microparticle NET NETosis NETs neutrophil neutrophil activation Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils occur pandemic pathogenic Patient Propylthiouracil Remission report resulting risk thrombi thrombogenesis thrombosis thrombotic thrombotic event Thrombotic events tissue Tissue Factor Trigger Vascular endothelium Vasculitis venous
[DOI] 10.1007/s10067-021-05790-9 PMC 바로가기 [Article Type] Review

PDZ-Containing Proteins Targeted by the ACE2 Receptor

Communication

Published on 2021-11-152022-10-28
Journal: Viruses [Category] COVID-19,

Killing Two Birds with One Stone by Administration of Soluble ACE2: A Promising Strategy to Treat Both Cardiovascular Diseases and SARS-CoV-2 Infection

Review

Published on 2021-11-082022-10-28
Journal: Viruses [Category] COVID-19, MERS, SARS,

Carbon dioxide inhibits COVID-19-type proinflammatory responses through extracellular signal-regulated kinases 1 and 2, novel carbon dioxide sensors

이산화탄소는 세포 외 신호 조절 키나아제 1 및 2, 새로운 이산화탄소 센서를 통해 COVID-19 유형 전염증 반응을 억제합니다

Original Article

Published on 2021-11-062022-09-12
Journal: Cellular and Molecular Life Sciences [Category] MERS, SARS, 진단,

[키워드] activated acute respiratory syndrome Anti-inflammatory Bicarbonate Brain bronchial epithelial cells carbon dioxide cause caused cellular cellular pathways clinical study Concentration coronavirus COVID-19 cytokine developmental processes Dexamethasone Diseases drug Effect effective elevated Endothelial cell ERK1 ERK2 excessive inflammatory response Extracellular hydrogen peroxide IFNγ inactivated indicate Infection Inflammation inhibit inhibitor interleukin-6 kidneys kinase Lungs MAPK mitogen-activated protein kinase Modification oncogenesis pathway Prevent Proinflammatory cytokine Proinflammatory response RBD reactive oxygen specy Research S protein Safe SARS-CoV-2 severe coronavirus disease severe COVID-19 supplementary material the receptor-binding domain the spike protein TNFα Treatment tumour necrosis factor-α
[DOI] 10.1007/s00018-021-04005-3 PMC 바로가기 [Article Type] Original Article

Monoclonal Human Antibodies That Recognise the Exposed N and C Terminal Regions of the Often-Overlooked SARS-CoV-2 ORF3a Transmembrane Protein

자주 볼 수있는 SARS-COV-2 ORF3A 횡단 단백질의 노출 된 N 및 C 말단 영역을 인식하는 단일 클론 인간 항체

Communication

Published on 2021-11-022022-09-01
Journal: Viruses [Category] MERS, SARS, 바이오마커, 진단,

[키워드] activities activity Analysis anti-ORF3a mAbs antibody antigens apoptosis induction autophagy binding affinities binding affinity C terminal calcium cellular complex conformation COVID-19 infections cytosolic diagnostic Disruption disturbance domain enzyme enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays epitope Epitopes evaluate evaluated Extracellular fluorescent fluorescent microscopy full-length generate homeostasis Human infected cell infected cells inflammasome activation involved linear Microscopy modulate monoclonal antibody N Terminal naïve ORF3a ORF3a protein pathophysiological peptide peptides performed prognostic biomarker Prognostic biomarkers Protein Proteins protocols recombinant antibodies Region SARS-CoV-2 SARS-CoV-2 infected cells selected surface plasmon surface plasmon resonance terminal therapeutic potential transfected cell transmembrane transmembrane protein viroporin western blot
[DOI] 10.3390/v13112201 PMC 바로가기 [Article Type] Communication

Prospective Case-Control Study of Cardiovascular Abnormalities 6 Months Following Mild COVID-19 in Healthcare Workers

의료 종사자의 경미한 COVID-19 이후 6개월 후 심혈관 기형에 대한 전향적 사례 대조 연구

Article

Published on 2021-11-012022-09-11
Journal: JACC. Cardiovascular imaging [Category] SARS, 치료기술,

[키워드] Abnormalities abnormality age artificial intelligence Asymptomatic disease Biomarker Biomarkers blinded Blood cardiovascular Cardiovascular Abnormalities Cardiovascular Abnormality Cardiovascular Magnetic Resonance Chain Reaction change concern control subject coronavirus disease Coronavirus disease 2019 COVID-19 defined detect edema Ejection fraction Extracellular first-wave fraction gadolinium groups Health care Health care worker healthy Hospitalized individual individuals Infection late gadolinium enhancement mass median Mild Month Myocardial myocardial edema myocarditis Myocardium N-terminal N-terminal pro-B-type natriuretic peptide no difference no differences participant peptide polymerase chain polymerase chain reaction Post-infection pro-B-type natriuretic peptide Prospective Prospective Study recruited reduced SARS-CoV-2 septal Seroconversion serology seronegative seropositive sex- subject Symptom tissue tissue characterization troponin vascular disease ventricular Volume volume fraction women worker
[DOI] 10.1016/j.jcmg.2021.04.011 PMC 바로가기 [Article Type] Article

Development of a recombinant vaccine containing a spike S1-Fc fusion protein induced protection against MERS-CoV in human DPP4 knockin transgenic mice

Article

Published on 2021-10-302022-11-01
Journal: Journal of virological methods [Category] Coronavirus, MERS,

[키워드] addition alum adjuvant antigen-specific neutralizing antibody baculovirus BALB/c mice BSL, biosafety level CEF, chicken embryo fibroblast cells Chinese hamster CHO, Chinese hamster ovary coronavirus demonstrated development Dipeptidyl peptidase-4 DPP4 effective ELISA, enzyme-linked immunosorbent assay Extracellular family Coronaviridae Fc fragment Fc, fragment of crystalline Fragment of crystalline (Fc) molecule fused fusion protein genus Betacoronavirus highly pathogenic human DPP4 humoral immune response Humoral immunity IgG IgG4 immunogenicity inflammatory cell infiltration inoculated lack MERS-CoV MERS-CoV infection MERS-CoV, Middle East respiratory syndrome coronavirus MERS, Middle East respiratory syndrome mice Middle East Middle East respiratory syndrome Coronavirus Neutralizing antibodies PBS, phosphate-buffered saline PBST, phosphate-buffered saline in 0.05 % Tween 20 PCR, polymerase chain reaction PFU, plaque-forming unit Protective Protein Proteins RBD, receptor-binding domain respiratory syndrome coronavirus RLU, relative light unit S1 subunit SARS-CoV, severe acute respiratory syndrome coronavirus secretion SFM, serum-free medium Spike protein therapeutic transgenic mice Vaccine vaccine candidate Vaccine development viral challenge viral outbreak virus
[DOI] 10.1016/j.jviromet.2021.114347 PMC 바로가기 [Article Type] Article

Functional Effects of Cardiomyocyte Injury in COVID-19

COVID-19에서 심근세포 손상의 기능적 효과

Cellular Response to Infection

Published on 2021-10-202022-09-10
Journal: Journal of Virology [Category] MERS, 유전자 메커니즘,

[키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect Analysis Blood cardiac disease Cardiomyocytes Cell clinical Clinical data Clinical finding Clinical findings Comorbidities Comorbidity Computational biology contractile contractile apparatus coronavirus COVID-19 COVID-19 patient COVID-19 patients Culture decrease decreased expression develop disease disorganization dysfunction echocardiography Effect elevated Elevation expression Extracellular healthy heart heart disease heart tissue hearts hospitalized patient hospitalized patients identify IL-1β IL-10 IL-1β IL-6 increase infect Infection Injury interleukin Interleukins Laboratory machine learning mechanism Mount Sinai Mount Sinai Health System mRNA multinucleated cells multiple organs NL63 observation Patient physiological physiological change physiological effect physiological effects pluripotent stem cell Protein reduced respiratory resulting SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus subject subset suppresse System Treatment Trigger triggers troponin troponin I underlie ventricular ventricular ejection Viral viral infection virus virus infection
[DOI] 10.1128/JVI.01063-21 PMC 바로가기 [Article Type] Cellular Response to Infection

Non-Randomized Trial of Dornase Alfa for Acute Respiratory Distress Syndrome Secondary to Covid-19

Clinical Trial

Published on 2021-10-202022-10-04
Journal: Frontiers in Immunology [Category] SARS, 임상,

[키워드] 95% CI ARDS BALF Bronchoalveolar lavage fluid cleaving clinical clinical trial complexes COVID - 19 COVID-19 Degradation develop DNA Dornase alfa Effect Effects evaluate the effect Extracellular extracellular DNA fraction Genentech improvement Inhaled inhibited Lung compliance MPO NET NETs Neutrophil extracellular trap non-randomized oxygen oxygen saturation Oxygenation P-value PaO Patient patients with ARDS performed pilot study Pneumonia positive reduction in Registration respiratory Respiratory failure Result secondary to Severe case Structure sustained therapy treatment group Viral
[DOI] 10.3389/fimmu.2021.714833 PMC 바로가기 [Article Type] Clinical Trial