SARS-CoV-2 RT-PCR profile in 298 Indian COVID-19 patients: a retrospective observational studyObservational Study Published on 2021-01-092022-10-05 Journal: Pathogens and disease [Category] 임상, [키워드] age average collected Comorbidities conducted COVID COVID-19 COVID-19 patients different time points Elderly patient eligible enrolment first positive hospital knowledge Laboratory majority male nasopharyngeal New nucleic acid oropharyngeal swabs pandemic Patient PCR positivity PCR test performed positive RT-PCR Positive test positive test result profile profile. retrieved retrospective RT-PCR SARS CoV-2 SARS-CoV-2 SARS-CoV-2 RT-PCR statistically significant symptom onset symptomatic patient Treatment viral dynamics were excluded [DOI] 10.1093/femspd/ftaa064 PMC 바로가기 [Article Type] Observational Study
SARS-CoV-2 Viral RNA Shedding for More Than 87 Days in an Individual With an Impaired CD8+ T Cell ResponseCD8+ T 세포 반응이 손상된 개인에서 87일 이상 동안 SARS-CoV-2 바이러스 RNA 방출Observational Study Published on 2021-01-082022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 임상, 진단, 치료기술, [키워드] airway Antibody titer Antibody titers case subject CD4+ T cell CD8+ CD8+ T cell cellular immunity circulating Cohort COVID-19 Day detectable exhibited expected first positive Impaired in some individual individuals with COVID-19 Infection Neutralizing antibody response neutralizing antibody responses occur one individual plasma neutralization activity positive Prolonged Protein Re-infection response RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral RNA severe COVID-19 shedding subject subjects symptom onset T cell T cell responses T cells tested upper airway Viral Viral RNA Viral RNA shedding [DOI] 10.3389/fimmu.2020.618402 PMC 바로가기 [Article Type] Observational Study
COVID-19 and the public response: Knowledge, attitude and practice of the public in mitigating the pandemic in Addis Ababa, EthiopiaResearch Article Published on 2021-01-072022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] age change chi-square test Community conducted correlation correlation coefficient COVID-19 COVID-19 pandemic cross-sectional Data collection Descriptive statistics effort enrolled first positive Government information KAP knowledge majority mandatory media mitigate moderate objective pandemic participant performed positive attitude positive correlation preventive measure preventive measures questionnaire Result SARS-CoV-2 SPSS statistical analysis Symptom Transmission was performed [DOI] 10.1371/journal.pone.0244780 PMC 바로가기 [Article Type] Research Article
Control of a COVID-19 outbreak in a nursing home by general screening and cohort isolation in Germany, March to May 20202020년 3월부터 5월까지 독일의 일반 선별 및 코호트 격리를 통한 요양원의 COVID-19 발병 통제Observational Study Published on 2021-01-072022-09-12 Journal: Eurosurveillance [Category] Fulltext, MERS, 임상, 진단, [키워드] Asymptomatic Care Cohort Control coronavirus disease COVID-19 COVID-19 case COVID-19 negative COVID-19 outbreak described effort elderly first positive Follow-up Germany Infection infection control Intervention Isolation Nursing outbreak positive SARS-CoV-2 SARS-CoV-2 test Screening tested were recorded [DOI] 10.2807/1560-7917.ES.2021.26.1.2001365 PMC 바로가기 [Article Type] Observational Study
Comparison of Five Serological Assays for the Detection of SARS-CoV-2 AntibodiesArticle Published on 2021-01-062022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] acquisition agreement assays association Blood comparable Contact contribute Corona COVID-19 COVID-19 patient detection diagnostic Donor EBV first positive FIVE Immunoglobulin immunologically Patient PCR positive proportion ranged recorded reliability respiratory SARS-CoV-2 SARS-CoV-2-specific antibodies sensitivity sera serological result serology shown Surveillance test comparison virus was recorded [DOI] 10.3390/diagnostics11010078 PMC 바로가기 [Article Type] Article
Detection of severe acute respiratory syndrome coronavirus 2 in nasopharynx according to clinical phenotype of affected patients환자의 임상적 표현형에 따른 비인두의 중증급성호흡기증후군 코로나바이러스 2 검출Article Published on 2020-12-012022-09-11 Journal: Clinical microbiology and infection : the official [Category] SARS, 치료기술, [키워드] activities acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjusted affected analysed asymptomatic individual Asymptomatic individuals asymptomatic patient asymptomatic patients characterized clinical phenotype conducted consecutive negative tests Contact tracing coronavirus coronavirus disease Coronavirus disease 2019 Critically ill critically ill patients detection disease disease control disease severity Duration emergency department first positive four group four groups Hospitalized in viral individual individuals Infectious disease Infectivity intensive care intensive care unit intensive care units interquartile range investigated Italian Italy measure median Mild disease multivariate analyses Multivariate analysis nasopharyngeal Nasopharyngeal swab nasopharynx negativity no difference Patient PCR tests positive individual positive individuals positive test result real-time RT-PCR real-time RT-PCR test respiratory RT-PCR test RT-PCR tests SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specimen standard error symptomatic patient Symptomatic patients symptomatic status test result tested university university hospital upper respiratory upper respiratory tract Viral viral shedding Virology with mild disease [DOI] 10.1016/j.cmi.2020.08.041 PMC 바로가기 [Article Type] Article
Testing IgG antibodies against the RBD of SARS-CoV-2 is sufficient and necessary for COVID-19 diagnosisSARS-CoV-2의 RBD에 대한 IgG 항체 검사는 COVID-19 진단에 충분하고 필요합니다.Research Article Published on 2020-11-232022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, SARS, 진단, 치료기술, [키워드] acute phase antibody kinetics COVID 19 patient COVID-19 COVID-19 diagnosis COVID-19 pandemic COVID-19 patient COVID-19 patients Critical demonstrated detect develop diagnose diagnostic ELISA exposure to first positive healthy highlight house identify IgA IgA antibodies IgA level IgG antibodies IgG antibody IgG level IgG levels IgM individual Infection MOST PCR RBD Receptor binding domain regulated SARS-CoV-2 serological serum serum sample Seven specificity Spread tested Testing the disease the RBD Travel uninfected [DOI] 10.1371/journal.pone.0241164 PMC 바로가기 [Article Type] Research Article
Glasgow Early Treatment Arm Favirpiravir (GETAFIX) for adults with early stage COVID-19: A structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-11-192022-10-29 Journal: Trials [Category] COVID-19, SARS, [키워드] 1:1 48 hours able to swallow accompany addition age Alexandra Algorithm ALT Antiviral Arm AST authority baseline Blinding Breastfeeding childbearing clinical clinically clinician co-morbidities co-morbidity Concomitant medication contribute control arm COVID COVID-19 COVID-19 infection COVID-19 test death defined dialysis disease dissemination doses drug duration of symptom early early stage effective Efficacy eight element Elizabeth EudraCT European excluded experimental arm Factor Favipiravir female females first positive greater haemofiltration Health hereditary xanthinuria history hospital hospitalisation hypersensitivity hypertension Hypothesis impairment in-patient Infection Infirmary information Inpatient ISARIC4C ISRCTN Loading dose maintenance dose male measure mechanism medication men metabolite negative number obesity objective offered open label Other outcome Outpatient Oxygen therapy parallel group participant Patient patients patients with COVID-19 pharmacokinetic pharmacokinetics Point positive pregnancy test pregnant Primary outcome principal investigator protocol random randomisation randomised randomised controlled trial Randomised trial receive recruit recruited recruitment reducing reference Registered Regulating reported risk risk of death Safety Sample size SARS-CoV-2 sequence severe hepatic impairment severity Severity of disease Sex Standard Standard of care standard treatment standard treatment alone status Study protocol Symptom the primary endpoint the WHO Tolerability Total treated Treatment treatment allocation treatment for COVID-19 Trial ULN undergo union university website WHO with COVID-19 women [DOI] 10.1186/s13063-020-04891-1 PMC 바로가기 [Article Type] Letter
Silent disease and loss of taste and smell are common manifestations of SARS-COV-2 infection in a quarantine facility: Saudi ArabiaResearch Article Published on 2020-10-302022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] 95% CI Asymptomatic Asymptomatic carrier Clinical presentations Contact Contact tracing COVID-19 cross-sectional study determine disease disease spread effective false-positive result first positive implication individual individuals Infection laboratory-confirmed Loss Loss of Smell loss of taste manifestation measure median median time Mild mild symptoms objective occurred participant PCR positive positive PCR Prevalence quarantine Result Saudi Arabia setting significantly subjects Symptom symptomatic symptomatic and asymptomatic Symptoms Travel two groups viral clearance virus virus clearance [DOI] 10.1371/journal.pone.0241258 PMC 바로가기 [Article Type] Research Article
Convalescent plasma for the treatment of patients with severe coronavirus disease 2019: A preliminary reportResearch Article Published on 2020-10-052022-11-01 Journal: Journal of medical virology [Category] COVID-19, MERS, SARS, [키워드] 95% confidence interval acute respiratory syndrome addition adjusted hazard ratio Administered Admission Adverse age clinical benefits Cohort convalescent plasma Convalescent plasma therapy coronavirus coronavirus disease COVID‐19 COVID‐19 patient COVID‐19 Critical Donor event first positive group Influenza intensive care interquartile range invasive ventilation IQR majority median Mortality not significantly different onset of symptom outcome Passive immunotherapy Patient PCR plasma polymerase chain preliminary report primary endpoint reduced required Respiratory Support Result retrospective SARS‐CoV‐2 SARS‐CoV‐2 severe coronavirus disease significantly standard care study groups the primary endpoint Treatment Trial two groups viral clearance [DOI] 10.1002/jmv.26537 PMC 바로가기 [Article Type] Research Article