The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsinLetter Published on 2020-06-122022-10-29 Journal: Signal Transduction and Targeted Therapy [Category] COVID-19, Fulltext, SARS, [키워드] absence furin cleavage site Infection membrane fusion Pathogenesis SARS-CoV-2 spike trypsin [DOI] 10.1038/s41392-020-0184-0 PMC 바로가기 [Article Type] Letter
Identification of SARS-CoV-2 Vaccine Epitopes Predicted to Induce Long-Term Population-Scale ImmunityReport Published on 2020-06-082022-10-31 Journal: Cell Reports Medicine [Category] COVID-19, [키워드] ACE2 receptor activate Adaptive immune response B cell epitopes binding can be used CD4 CD8 conserved coronavirus coronavirus Coronaviruses COVID-19 DNA DNA vaccine domain Efficacy engage epitope expected furin cleavage site generate genomic region histocompatibility complex HLA identification Immunity immunogenicity implementation include majority membrane fusion MHC mRNA peptide predicted proteome Region reported RNA RNA vaccine robust SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 vaccine SARS2 subset tested the spike protein thought Vaccine Vaccines validation viral genome [DOI] 10.1016/j.xcrm.2020.100036 PMC 바로가기 [Article Type] Report
The S2 Subunit of QX-type Infectious Bronchitis Coronavirus Spike Protein Is an Essential Determinant of NeurotropismArticle Published on 2019-10-222022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] Adsorption condition coronavirus coronavirus CoVs determinant effective Encephalitis Essential Evidence experiment furin cleavage site furin-S2′ site fusion peptide Genotype IBV in vitro in vivo induce Infectious Bronchitis Virus Mortality mutant neurotropism neutralization pathogenicity QX type S2′ site serum spike Spike protein Symptom the spike protein upstream Vaccine virion virus wild-type [DOI] 10.3390/v11100972 PMC 바로가기 [Article Type] Article
Coronavirus Cell Entry Occurs through the Endo-/Lysosomal Pathway in a Proteolysis-Dependent MannerResearch Article Published on 2014-11-062022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] Cell cell entry Clathrin-mediated endocytosis cleavage conformational change coronavirus coronavirus CoV CoVs demonstrated endocytosed endosomal maturation endosomal pH entry pathway expressing furin furin cleavage site fusion fusion peptide fusion protein gene silencing Genome Host host cell host cell membrane induce Infection influenza A virus inhibited introduced investigated late endosomes less lysosomal protease lysosomal proteases lysosome membrane fusion MERS MERS-CoV MHV microenvironment mouse hepatitis murine hepatitis virus negatively affected occur pathogen plasma membrane predicted previous study promote protease Protease inhibitor Protein proteolytic cleavage Proteolytic processing reporter required S protein shown siRNA Specific the S protein upstream vesicular stomatitis virus virus virus while zoonotic [DOI] 10.1371/journal.ppat.1004502 PMC 바로가기 [Article Type] Research Article
Mutation in Spike Protein Cleavage Site and Pathogenesis of Feline CoronavirusResearch Published on 2013-07-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] arise assay cause cleavage compared conserved conserved furin cleavage motif coronavirus coronavirus Coronaviruses correlation develop diagnostic domain examined fatal disease FECV Feline coronavirus feline enteric coronavirus Feline infectious peritonitis Feline infectious peritonitis virus FIP FIPV furin furin cleavage motif furin cleavage site Infection infectious Macrophage macrophages measure modulate molecular basis motif Mutation Pathogenesis pathology peptide protease protein processing S1/S2 sequence serotype Site spike Substitution the disease thought Treatment virus viruses [DOI] 10.3201/eid1907.121094 PMC 바로가기 [Article Type] Research