From musk to body odor: Decoding olfaction through genetic variation사향에서 신체 냄새로 : 유전자 변이를 통해 후각을 해독하는Research Article Published on 2022-02-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation Amino acid amino acid substitutions androstenone Anosmia association Body odor change cis-3-hexen-1-ol coding contribute derived allele ENCODE example explicit functional Galaxolide Genetic genetic diversity Genetic variation Han Chinese human body Hypothesis implication IMPROVE individual information input intensity ionone mechanism musk novel association olfactory olfactory receptor OR4D6 OR51B2 OR5A1 OR7D4 Perception performed phenotype populations Previous studies provide receptor receptors reduced replicated reported robust second shown SNP SNPs trans Variation [DOI] 10.1371/journal.pgen.1009564 PMC 바로가기 [Article Type] Research Article
Tracking cryptic SARS-CoV-2 lineages detected in NYC wastewaterArticle Published on 2022-02-032022-10-04 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] ACE2 receptor affecting Amino acid antibodies Cell clinical samples coding sequence COVID-19 infection database expand expressing Frequency genetic diversity hypothese indicated Infection Lineage lineages MONITOR Mutation neutralization neutralizing monoclonal antibodies New York City offer omicron pseudovirus Q498Y Receptor binding domain S protein SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 variant sequence the S protein tropism of SARS-CoV-2 Vaccine-induced immunity variant variants Water microbiology [DOI] 10.1038/s41467-022-28246-3 PMC 바로가기 [Article Type] Article
Ongoing Recombination in SARS-CoV-2 Revealed through Genealogical Reconstruction족보 재구성을 통해 밝혀진 SARS-CoV-2의 진행 중인 재조합Discoveries Published on 2022-02-022022-09-10 Journal: Molecular Biology and Evolution [Category] COVID19(2023년), MERS, SARS, 변종, 치료기술, [키워드] Affect collected Effect England Evidence evidence of genealogy Genetic genetic diversity genetic recombination Inference parsimony phylogenetic analyses Phylogenetic analysis Probability Recombination recombination event reconstruction recurrent mutation resolved Revealed SARS-CoV-2 SARS-CoV-2 sequences sequencing data significantly South Africa statistical framework Treatment Vaccines Viral viral pathogen [DOI] 10.1093/molbev/msac028 PMC 바로가기 [Article Type] Discoveries
High genetic diversity in Plasmodium falciparum isolates among Chinese migrant workers returnee from Africaarticle Published on 2022-01-312024-09-01 Journal: Parasitology Research [Category] 말라리아, [키워드] Africa China genetic diversity genotyping Plasmodium falciparum [Article Type] article
Plasmodium falciparum msp1 and msp2 genetic diversity in parasites isolated from symptomatic and asymptomatic malaria subjects in the South of Beninarticle Published on 2022-01-312024-09-01 Journal: Parasitology Research [Category] 말라리아, [키워드] Asymptomatic genetic diversity malaria South of Benin symptomatic [Article Type] article
Nosocomial transmission clusters and lineage diversity characterized by SARS-CoV-2 genomes from two large hospitals in Paris, France, in 20202020 년 프랑스 파리의 두 대형 병원의 SARS-COV-2 게놈을 특징으로하는 병원 전달 클러스터 및 계통 다양성Clinical Trial Published on 2022-01-202022-09-10 Journal: Scientific Reports [Category] 변종, 임상, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 change characterized clade clades Cluster Clustering Clusters connection Contamination coronavirus Course COVID-19 epidemic wave epidemic waves epidemiological data Epidemiology France genetic diversity Genome sequencing HCW HCWs Health care Health care worker health care workers healthcare help highest hospital hospitals identify incidence involved joint Lineage Next-generation sequencing nosocomial Nosocomial transmission pandemic Paris participant Patient performed Phylogenetic Phylogenetic analysis Phylogeny potential transmission prevalent proportion public health Region respiratory SARS-CoV-2 SARS-CoV-2 genome Sequencing severe acute respiratory syndrome Coronavirus summer the SARS-CoV-2 transmission clusters two groups Viral viral epidemiology viral evolution viral infection were used [DOI] 10.1038/s41598-022-05085-2 PMC 바로가기 [Article Type] Clinical Trial
Immunodominant and Neutralizing Linear B-Cell Epitopes Spanning the Spike and Membrane Proteins of Porcine Epidemic Diarrhea VirusImmunology Published on 2022-01-192022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, [키워드] amino acid sequence B-cell epitope cause Complete consensus sequence contribute demonstrated disease ELISA testing epidemic diarrhea epitope Epitope prediction genetic diversity greater group high mortality rate identify immune stimulation immunodominant epitope immunoinformatics insight linear linear B-cell epitope M protein membrane membrane protein NCBI database neutralization Neutralizing neutralizing epitope nine offer PEDV peptide peptide-based immunoassays Porcine epidemic diarrhea virus predicted profile Protein Proteins provided retrieved S2 subunit sera Seven Spike protein strain Strains the S protein the Spike Vaccine virus Virus neutralization [DOI] 10.3389/fimmu.2021.785293 PMC 바로가기 [Article Type] Immunology
Molecular Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 Isolates From Central Inner SardiniaMicrobiology Published on 2022-01-142022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] Amplicon Analysis approach characterization characterized circulation Cluster conserved coronavirus 2 COVID-19 distribution effort Epidemiology Evolution Frequency Genes genetic diversity Genome sequencing geographical location incidence increasingly Infection Inner involved isolate Italy Lineage mapping Measures Missense molecular characterization MONITOR mutated Mutation mutation rate N gene next generation sequencing Nucleocapsid proteins nucleotide nucleotides pandemic pandemic (COVID-19) Phylogeny Prevalence Public health intervention RdRP respiratory respiratory sample Result S gene Sardinia Sardinia—Italy SARS-CoV-2 SARS-CoV-2 infected patient SARS-CoV-2 pandemic sequence Sequencing stimulated subsequent synonymous synonymous variant the spike protein transmission clusters Variability variant viral genome widespread [DOI] 10.3389/fmicb.2021.827799 PMC 바로가기 [Article Type] Microbiology
A Genomic Snapshot of the SARS-CoV-2 Pandemic in the Balearic IslandsMicrobiology Published on 2022-01-122022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acquisition additional Spike mutations assigned B.1 B.1.1.7 B.1.177 B.1.617.2 Balearic Island Balearic Islands circulating circulating variant complex interplay Consensus Course COVID-19 case distribution distribution analysis driven by epidemic wave Epidemiology genetic diversity Genome genomic Genomic epidemiology genomic evolution key factor Lineage Lineage B.1.1.7 Mutation pandemic positive prevalent Randomly Registered respiratory sample SARS-CoV-2 selected sequence sequenced spike mutation spike mutations Substitution Temporal the epidemic the SARS-CoV-2 the WHO unique variant variants Virus evolution VoC whole genome sequence [DOI] 10.3389/fmicb.2021.803827 PMC 바로가기 [Article Type] Microbiology
Structural insights in cell-type specific evolution of intra-host diversity by SARS-CoV-2Article Published on 2022-01-112022-10-04 Journal: Nature Communications [Category] SARS, 변종, 유전자 메커니즘, [키워드] ACE2 receptor binding addition amino-acid cell type cell types cleavage site Cryoelectron microscopy deletion variant domain eight Evolution functional furin recognition motif genetic diversity Host Intra-host diversity modulate molecular Molecular modelling pathology provide RNA virus S1/S2 cleavage site SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant subpopulation Support trajectory Transmissibility variant viral cell Viral proteins viral variant virus infectivity wild-type [DOI] 10.1038/s41467-021-27881-6 PMC 바로가기 [Article Type] Article