genetic variants – Page 9 – Communicable Diseases Research

Gene variants of coagulation related proteins that interact with SARS-CoV-2

SARS-CoV-2와 상호작용하는 응고 관련 단백질의 유전자 변이체

Research Article

Published on 2021-03-172022-09-10
Journal: PLoS Computational Biology [Category] SARS, 변종, 유전자 메커니즘,

Genomic monitoring of SARS-CoV-2 uncovers an Nsp1 deletion variant that modulates type I interferon response

SARS-CoV-2의 게놈 모니터링은 I형 인터페론 반응을 조절하는 Nsp1 결실 변이체를 밝혀냅니다

Article

Published on 2021-03-102022-09-11
Journal: Cell Host & Microbe [Category] Fulltext, SARS, 변종, 유전자 메커니즘, 진단,

[키워드] approach association calu-3 cells causative agent clinical phenotype clinical phenotypes clinical sample clinical samples country COVID-19 cycle threshold Deletion deletion variant Deletion variants diagnostics drug design Epidemiology experimental validation Genetic genetic diversity genetic variants genetics genomic Genomic epidemiology IFN-β induce infected patients interferon locus modulate molecular molecular diagnostics Mutation nsp1 response reverse genetics RT-PCR SARS-CoV-2 SARS-CoV-2 virus sequenced sample Sequencing serum severity Surveillance type I interferon variant variants virus virus genome viruses
[DOI] 10.1016/j.chom.2021.01.015 PMC 바로가기 [Article Type] Article

The Role of Immunogenetics in COVID-19

COVID-19에서 면역유전학의 역할

Review

Published on 2021-03-052022-09-10
Journal: International Journal of Molecular Sciences [Category] 변종, 신약개발, 유전자 메커니즘,

[키워드] AB0 Asymptomatic available data clinical manifestations coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients cytokine Cytokine storm disease Drug repurposing Evolution experimental evidence genetic variability Genetic variant genetic variants help HLA Host immune response immune system Immunogenetics immunosenescence Impact IMPROVE KIR knowledge life-threatening maintenance molecular mechanism Multiorgan outcome reactivity Research Respiratory failure role SARS-CoV-2 SARS-COV-2 infection susceptibility the disease Therapeutic strategies Treatment Variability variety Viral viral infection viral infections
[DOI] 10.3390/ijms22052636 PMC 바로가기 [Article Type] Review

Public health actions to control new SARS-CoV-2 variants

새로운 SARS-CoV-2 변종을 통제하기 위한 공중 보건 조치

Article

Published on 2021-03-042022-09-11
Journal: Cell [Category] SARS, 변종,

[키워드] B.1.1.7 community transmission exacerbate genetic variants Guidance Health health guidance measure new SARS-CoV-2 pandemic Public public health recent reduce SARS-CoV-2 Surveillance transmissible variant variant
[DOI] 10.1016/j.cell.2021.01.044 PMC 바로가기 [Article Type] Article

Cardiometabolic risk factors for COVID-19 susceptibility and severity: A Mendelian randomization analysis

COVID-19 감수성 및 중증도에 대한 심혈관 대사 위험 요소: 멘델식 무작위 분석

Research Article

Published on 2021-03-042022-08-13
Journal: PLoS Medicine [Category] meta-analysis, SARS, 변종, 유전자 메커니즘, 진단, 치료제,

[키워드] Aaron amplified amplify analyses Analysis association associations average BMI body mass body mass index calculated cardiometabolic cardiometabolic condition cardiometabolic conditions cardiometabolic consequence cardiometabolic disease cardiometabolic diseases cardiometabolic exposure cardiometabolic risk factor Cardiometabolic risk factors cardiometabolic trait cardiometabolic traits causal relationship Causality Chronic kidney disease cohorts Conditioning Control controls Coronary artery Coronary artery disease Coronary heart disease correlated COVID-10 COVID-19 COVID-19 disease COVID-19 hospitalization COVID-19 Host Genetics Initiative GWAS meta-analyses COVID-19 illness COVID-19 pandemic COVID-19 severity COVID-19 susceptibility defined described diabetes Effect estimate European evaluate Evidence General population Genetic genetic evidence genetic instrument Genetic variant genetic variants Genome-wide association studies Genome-wide association study GWAS meta-analysis GWASs higher risk hospital Hospitalization hospitalized COVID-19 indirect effect indirect effects individual initiative Intervention Kidney disease mediators mendelian randomization Mendelian randomization analyses Mendelian randomization analysis obesity Obesity-related cardiometabolic diseases Odds ratio on type outcome outcomes p < 0.05/34 tests pairwise multivariable MR performed Pleiotropy population-based cohort population-based cohorts positive raise raising reduce repeated researcher risk risk factor Risk factors risk of COVID-19 selected severe COVID-19 severity statistical significance statistically significant stroke Support susceptibility tested traits type 2 diabetes UK biobank with COVID-19
[DOI] 10.1371/journal.pmed.1003553 PMC 바로가기 [Article Type] Research Article

The effect of angiotensin-converting enzyme levels on COVID-19 susceptibility and severity: a Mendelian randomization study

COVID-19 감수성 및 중증도에 대한 지오텐신 전환 효소 수치의 영향: 멘델식 무작위 배정 연구

Article

Published on 2021-03-032022-09-11
Journal: International Journal of Epidemiology [Category] SARS, 변종,

[키워드] 95% CI 95% confidence interval ACE ACE gene ACE inhibitor ACE inhibitors Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme. benefit Cohort cohorts COVID-19 COVID-19 disease COVID-19 pandemic COVID-19 severity COVID-19 susceptibility decrease European explain genetic determinant genetic determinants Genetic variant genetic variants Genome-wide association study GWAS Hospitalization Icelanders increase in individual inhibitor initiative Latino mendelian randomization observational studies Odds ratio outcome performed reducing SARS-COV-2 infection Sensitivity analyses serum severe disease severity susceptibility therapy These data Trial variance variant were used
[DOI] 10.1093/ije/dyaa229 PMC 바로가기 [Article Type] Article

Association of serum HDL-cholesterol and apolipoprotein A1 levels with risk of severe SARS-CoV-2 infection

심각한 SARS-CoV-2 감염 위험과 혈청 HDL-콜레스테롤 및 아포지단백 A1 수치의 연관성

Multicenter Study

Published on 2021-03-022022-09-10
Journal: Journal of Lipid Research [Category] 바이오마커, 변종,

[키워드] 95% CI, 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age allele alleles ApoA1, apolipoprotein A1 APOE4 apolipoprotein A1 association Biomarker CAD, coronary artery disease cholesterol clinical risk factor Clinical risk factors Coronary artery Coronary artery disease coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19, Coronavirus disease 2019 cumulative cumulative effects diabetes Effect elevated evaluated Evidence feature genetic risk score Genetic variant genetic variants GRS, genetic risk scores HDL-cholesterol higher risk homozygous hypertension ICD-10, International Classification of Diseases, Tenth Revision increase in individual Infection investigated Logistic regression analyses Logistic regression analysis mendelian randomization Mendelian randomization analyses Mendelian randomization analysis metabolic syndrome Mortality MR, Mendelian randomization MVMR, multivariate MR negative controls Novel coronavirus obesity OR, odds ratio outcomes PC, principal component reduced risk respiratory Respiratory disease risk SAR-CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 serum serum biomarker serum biomarkers severe acute respiratory syndrome Coronavirus Severe COVID-19 Infection severe respiratory disease severe SARS-CoV-2 severity of COVID-19 Sex susceptible syndrome type 2 diabetes UK biobank were used
[DOI] 10.1016/j.jlr.2021.100061 PMC 바로가기 [Article Type] Multicenter Study

Shared genetic etiology between idiopathic pulmonary fibrosis and COVID-19 severity

특발성 폐섬유증과 COVID-19 중증도 사이의 유전적 병인 공유

Article

Published on 2021-03-012022-09-11
Journal: EBioMedicine [Category] SARS, 변종, 유전자 메커니즘, 진단, 치료기술,

[키워드] airway airways Analysis association carriers causal variant characterized combined effect complex controls correlation COVID-19 COVID-19 hospitalization COVID-19 Host Genetics Initiative COVID-19 severity determine Effect estimate Evidence excluded explanation fibrosis foundation Genetic genetic association genetic determinant genetic etiology genetic risk factors genetic variants Genome-wide association study GWAS GWAS meta-analysis idiopathic Idiopathic pulmonary fibrosis increased risk initiative instrumental variable instrumental variables IPF Linkage disequilibrium lung Lung disease mendelian randomization MUC5B mucin Oak Older Older adults other variants outlier Patient performed Pneumonitis positive protective effect Protective effects provided pulmonary fibrosis risk allele risk factor risk loci risk of COVID-19 SARS-COV-2 infection scarring selection bia Selection bias Self-isolation severe COVID-19 severity survival susceptibility the strongest variance variant were used with COVID-19
[DOI] 10.1016/j.ebiom.2021.103277 PMC 바로가기 [Article Type] Article

Genetic variants are identified to increase risk of COVID-19 related mortality from UK Biobank data

UK Biobank 데이터에서 유전적 변이가 COVID-19 관련 사망 위험을 증가시키는 것으로 확인되었습니다.

Primary Research

Published on 2021-02-032022-09-10
Journal: Human Genomics [Category] MERS, 변종, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 associations bronchial epithelial cell cardiovascular disease cardiovascular diseases caused chromosome chromosomes CLUAP1 coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 mortality dataset death deaths DES DNAH7 downregulated gene dysfunction ENhance epithelial cells ethnic group Ethnic groups Factors Genetic genetic factors Genetic variant genetic variants Genome-wide association study genome-wide significant GWAS heterogeneous Host Host genetic factors human bronchial epithelial cells identify increased risk infected case infecting innate immune system interactions male mitochondrial mitochondrial dysfunction molecular Mortality pathogenesis of COVID-19 power Replication reported respiratory Result risk factor risk of COVID-19 risk of death SARS-CoV-2 severe acute respiratory syndrome Coronavirus severity significantly SPEG STXBP5 supplementary material susceptibility susceptibility loci the patient therapeutic options thromboembolic thromboembolic disease TOMM7 Traditional UK biobank UK Biobank data variant WSB1
[DOI] 10.1186/s40246-021-00306-7 PMC 바로가기 [Article Type] Primary Research

Modifiable lifestyle factors and severe COVID-19 risk: a Mendelian randomisation study

수정 가능한 생활 방식 요인과 심각한 COVID-19 위험: 멘델식 무작위 배정 연구

Research Article

Published on 2021-02-032022-09-10
Journal: BMC Medical Genomics [Category] MERS, 변종,

[키워드] 95% CI 95% confidence interval alcohol alcohol consumption Analysis association BMI body mass body mass index Causation assessment conducted controls correlated COVID-19 COVID-19 hospitalization COVID-19 pandemic death decrease deviation evidence of Factor Factors Genetic variant genetic variants Genome-wide association study GWAS healthy highlight Hospitalization increase in increased risk individual instrumental variables large-scale genome-wide association studies Lifestyle factors Mendelian randomisation no evidence of obesity Odds ratio physical activity predicted public health randomisation respiratory Result risk risk of COVID-19 robust selected severe COVID-19 smoking suggested with COVID-19
[DOI] 10.1186/s12920-021-00887-1 PMC 바로가기 [Article Type] Research Article