SARS-CoV-2 variants of concern dominate in Lahore, Pakistan in April 20212021년 4월 파키스탄 라호르에서 우려되는 SARS-CoV-2 변종 우세Research Articles Published on 2021-11-302022-09-10 Journal: Microbial Genomics [Category] MERS, SARS, 변종, [키워드] Alpha Alpha variant ARTIC Beta Beta variant caused circulating circulation collected continent country cutoff value depth analysis diagnostic effective Europe Evidence expand Genome Genome sequencing genomes genomic Genomic epidemiology highlight hospital indicated Infection less Lineage lineages low-density NGS nine PCR populations Randomly rising SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 pandemic SARS-CoV-2 variant sequenced Sequencing Seven South Africa subsequent Surveillance sustained Switzerland Transmission Travel Vaccine variant variants [DOI] 10.1099/mgen.0.000693 PMC 바로가기 [Article Type] Research Articles
Template switching and duplications in SARS-CoV-2 genomes give rise to insertion variants that merit monitoringArticle Published on 2021-11-302022-10-31 Journal: Communications Biology [Category] COVID-19, SARS, [키워드] Affect Analysis antigenic B.1.1.7 B.1.351 B.1.617.2 consensus genome Course COVID-19 pandemic Deletion duplication Effect escaped Evidence furin site Genome informatics genomes higher infectivity identify insertion mechanism N-terminal domain Neutralizing antibodies new SARS-CoV-2 nucleotide substitution pandemic pathogenicity polymerase predicted Protein researcher SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variants Sequencing subgenomic RNAs switching T-cell immunity Template the S protein the SARS-CoV-2 the Spike thought unique variant variants virulence virus [DOI] 10.1038/s42003-021-02858-9 PMC 바로가기 [Article Type] Article
Structure–function analysis of the nsp14 N7–guanine methyltransferase reveals an essential role in Betacoronavirus replication423 Published on 2021-11-292022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, [키워드] acute respiratory syndrome affecting Analysis approach Betacoronavirus betacoronaviruses biochemical C-terminal catalytic cellular characterized conserved coronavirus CoV CoVs Critical defined Degradation develop domain drugs enzymatic activity enzyme Exoribonuclease feature genomes highlight host cell cytoplasm identify in silico in viral inhibitor innate immune involved MERS-CoV Messenger RNA methyltransferase Middle East MOST mRNA mRNA capping mRNAs Mutation N-terminal nonstructural protein 14 nsp14 nsp14-ExoN pandemic phenotype PROTECT replicate Replication replicative residue reveal RNA synthesis SARS-CoV SARS-CoV-2 selected Significance site-directed mutagenesis Substitution subunit syndrome targets tested translation unique viability Virological virus was used yielding [DOI] 10.1073/pnas.2108709118 PMC 바로가기 [Article Type] 423
Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structuresResearch Article Published on 2021-11-262022-11-01 Journal: Science Advances [Category] COVID-19, [키워드] Amiloride Antiviral antivirals conserved coronavirus CoV description docking element genomes in vitro inhibit inhibit SARS-CoV-2 Interaction likelihood OC43 offer Pandemics predicted probe proximal Region Replication retrospective reveal RNA RNA structure SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 replication small molecule Structure target therapeutic virus replication [DOI] 10.1126/sciadv.abl6096 PMC 바로가기 [Article Type] Research Article
Re-emergence of Gamma-like-II and emergence of Gamma-S:E661D SARS-CoV-2 lineages in the south of Brazil after the 2021 outbreak2021 년 발발 후 브라질 남쪽의 감마와 같은 II 및 감마 SARS-COV-2 계통의 재발Research Published on 2021-11-172022-09-10 Journal: Virology Journal [Category] MERS, SARS, 변종, 치료기술, [키워드] added addition age Analysis analyzed B.1.1.28 B.1.1.33 Brazil carried characterized circulating clade Clinical data correlation COVID-19 described dominance effort Evolution Frequency Gamma Gamma-like-II and new mutations Genome genomes genomic genomic sequence Genomic surveillance GISAID Lineage Mutation Older outbreak P.1 P.2 pandemic performed phylogenetic analyses Phylogenetic analyses of SARS-CoV-2 Phylogenetic tree predominant Protein provided ramification random Region responsible Result SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 lineage SARS-CoV-2 pandemic SARS-CoV-2 sequencing second wave sequence sequences supplementary material Surveillance the SARS-CoV-2 the SARS-CoV-2 genome thought variant variants VoC VOC Gamma was performed [DOI] 10.1186/s12985-021-01690-1 PMC 바로가기 [Article Type] Research
Early Adoption of Longitudinal Surveillance for SARS-CoV-2 among Staff in Long-Term Care Facilities: Prevalence, Virologic and Sequence Analysis장기 요양 시설 직원의 SARS-CoV-2 종단 감시 조기 채택: 유병률, 바이러스 및 염기서열 분석Research Article Published on 2021-11-102022-09-12 Journal: Microbiology Spectrum [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adoption advanced age Analysis Asymptomatic asymptomatic infections Care Characteristics Cohort collected Comorbidities Complete contributed coronavirus COVID-19 death declining epidemiological Epidemiology event Genetic Genetic epidemiology genomes genomic Impact incidence individuals Infection infections Infectious disease Infectious virus less Long-term care longitudinal nasal swab Nasopharyngeal swab nasopharyngeal swabs notable outcome pandemic pathogen performed persistence presence of comorbidities Prevalence risk factor SARS-CoV-2 SARS-CoV-2 dynamics SARS-COV-2 infection SARS-CoV-2 pandemic SARS-CoV-2 PCR sequenced severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spread staff subset Support Surveillance surveillance testing symptomatic the SARS-CoV-2 The United States Transmission Transmission dynamics transmission of SARS-CoV-2 unique United States Viral RNA virus vRNA Workplace [DOI] 10.1128/Spectrum.01003-21 PMC 바로가기 [Article Type] Research Article
External Quality Assessment of SARS-CoV-2 Sequencing: an ESGMD-SSM Pilot Trial across 15 European LaboratoriesSARS-CoV-2 염기서열 분석의 외부 품질 평가: 15개 유럽 연구소에 걸친 ESGMD-SSM 파일럿 시험Virology Published on 2021-11-102022-09-10 Journal: Journal of Clinical Microbiology [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyses Analysis assessment build clinical clinical laboratories Cluster Consensus Contamination coronavirus criteria discrepancies discrepancy European External external quality assessment Follow-up format framework generate genomes group IMPROVE indels Infectious disease Infectious diseases initiated Interpretation Laboratory Lineage lineages majority Microbiology MOST NGS nucleotide occurred pathogen problem problems Quality report respiratory ring trial SARS-CoV-2 sequenced Sequencing sequencing method severe acute respiratory syndrome Coronavirus Single nucleotide polymorphism single nucleotide polymorphisms SNPs Society study group Surveillance Trial variable variant Viral Viral load whole genome whole genomes whole-genome sequencing [DOI] 10.1128/JCM.01698-21 PMC 바로가기 [Article Type] Virology
Explosive nosocomial outbreak of SARS-CoV-2 in a rehabilitation clinic: the limits of genomics for outbreak reconstruction재활 클리닉에서 SARS-CoV-2의 폭발적인 병원 발병: 발병 재구성을 위한 게놈의 한계Article Published on 2021-11-012022-09-11 Journal: The Journal of hospital infection [Category] SARS, 유전자 메커니즘, [키워드] 95% CI 95% confidence interval acquisition acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adjusted odds ratio Analysis Bayesian framework case-control study clinical Cluster Coronavirus-2 Coverage COVID-19 epidemiological data events excess expected Explosive fraction genetic diversity Genome genomes genomic greater HCW HCWs healthcare healthcare worker Healthcare workers Healthcare-associated infection highlight implementation index case Infection infection control Infection prevention Infection prevention and control investigated involved isolate likelihood limit Limited Limited genetic diversity Long-term care long-term care facilities Measures nosocomial nosocomial COVID-19 Nosocomial outbreaks outbreak Outbreak investigation pathogen Patient patients peak Phylogenetic tree Phylogeny Prevention and control reconstructed reconstruction rehabilitation Reproduction number resulting risk risk factor Risk factors SARS-CoV-2 SARS-CoV-2 transmission scale Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 significantly statistical Transmission transmission pattern was performed was used WGS Whole-genome sequence [DOI] 10.1016/j.jhin.2021.07.013 PMC 바로가기 [Article Type] Article
Causes and Consequences of Purifying Selection on SARS-CoV-2SARS-CoV-2에 대한 정제 선택의 원인과 결과Research Article Published on 2021-10-242022-09-10 Journal: Genome Biology and Evolution [Category] MERS, SARS, 변종, [키워드] Amino acid amino acids Analysis appearance cause classical codon usage complex consequence degenerate Deleterious disparate disrupt Evidence Evolution genomes humans implication Ka/K less lineages majority Missense Mutation mutation rate mutations nonsense mutation Nonsense mutations offspring parameters parent parents predicted Protein purging Purifying purifying selection SARS-CoV-2 Selection selective SNP synonymous Vaccine variant variants [DOI] 10.1093/gbe/evab196 PMC 바로가기 [Article Type] Research Article
Capsid integrity RT-qPCR for the selective detection of intact SARS-CoV-2 in wastewater폐수에서 온전한 SARS-CoV-2의 선택적 검출을 위한 캡시드 무결성 RT-qPCRArticle Published on 2021-10-152022-09-11 Journal: The Science of the total environment [Category] SARS, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus applicability Area biosafety level Biosafety Level 3 capsid Capsid integrity RT-qPCR collected Concentration Concentration method coronavirus determine determined by Effect EMA evaluated form Genome genomes glycol heat-inactivated IMPROVE intact virus Interpretation investigated level 3 MHV murine hepatitis virus PMA Polyethylene glycol positive positive result positive sample qPCR reagents RT-qPCR SARS-CoV-2 selective severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 surrogate tested Tokyo Ultrafiltration virus was used wastewater [DOI] 10.1016/j.scitotenv.2021.148342 PMC 바로가기 [Article Type] Article