geometric – Page 9 – Communicable Diseases Research

BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans

Research

Published on 2021-05-272022-10-05
Journal: Nature [Category] SARS, 변종, 유전자 메커니즘, 임상, 치료제,

Deep learning the structural determinants of protein biochemical properties by comparing structural ensembles with DiffNets

Article

Published on 2021-05-212022-10-04
Journal: Nature Communications [Category] 변종,

Development and Validation of a Multiplex Microsphere Immunoassay Using Dried Blood Spots for SARS-CoV-2 Seroprevalence: Application in First Responders in Colorado, USA

SARS-CoV-2 혈청 유병률에 대한 건조혈액 반점을 사용한 다중 미소구체 면역분석법의 개발 및 검증: 미국 콜로라도주 응급구조대에 적용

Article

Published on 2021-05-192022-09-11
Journal: Journal of Clinical Microbiology [Category] SARS, 진단, 치료법,

[키워드] anti-N antibodies anti-N antibody anti-N IgG anti-RBD Anti-RBD IgG antibody Antibody Response Antibody responses Antibody testing application applied Blood correlated COVID-19 antibody COVID-19 antibody testing development dried blood spot testing ELISA enzyme enzyme immunoassay enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluated first responders fluorescence intensity geometric immunoassay Immunological Surveillance immunological surveillance. less median microsphere multiplex natural infection Neutralizing antibodies nucleocapsid Population predicted RBD RBD IgG Receptor binding domain Responder SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection serological testing SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody serological Serological testing seropositive Seroprevalence serum spot the United State Transmission dynamics United States USA vaccination validation
[DOI] 10.1128/JCM.00290-21 PMC 바로가기 [Article Type] Article

Increasing efficacy of contact-tracing applications by user referrals and stricter quarantining

Research Article

Published on 2021-05-192022-10-28
Journal: PLoS ONE [Category] Coronavirus, MERS, SARS,

[키워드] absence addition Contact COVID-19 epidemic CTA CTAs Effect effective Efficacy epidemiological geometric hospital IMPROVE Increasing individual initial measure Measures mechanism Mild quarantine random Randomly reduce reduced reducing severity significantly Spread Super-spreader the epidemic Travel turn
[DOI] 10.1371/journal.pone.0250435 PMC 바로가기 [Article Type] Research Article

Safety and immunogenicity of the SARS-CoV-2 BNT162b1 mRNA vaccine in younger and older Chinese adults: a randomized, placebo-controlled, double-blind phase 1 study

Research

Published on 2021-04-222022-10-05
Journal: Nature Medicine [Category] SARS, 임상, 진단,

[키워드] acute respiratory syndrome Adults adverse event Asian BNT162b1 China Chinese clinical investigation convalescent coronavirus COVID-19 domain dose double-blind effective ENCODE event geometric healthy human sera humoral immunogenicity data interferon-γ Jiangsu local reaction Mild moderate mRNA vaccine Neutralizing titer Older pandemic parallel-group participant Participants peptide pool phase 1 study phase 1 trial Placebo placebo-controlled polymerase chain positive prime and boost Randomized RBD reached receive response robust Safety safety profile SARS-CoV-2 single-center spike glycoprotein the RBD the SARS-CoV-2 the vaccine Tolerability treatment group vaccination Vaccine vaccine candidate
[DOI] 10.1038/s41591-021-01330-9 [Article Type] Research

Electrochemically active materials and wearable biosensors for the in situ analysis of body fluids for human healthcare

Reviews

Published on 2021-04-012022-10-05
Journal: NPG Asia Materials [Category] 바이오마커,

[키워드] Analysis biochemical body fluid body fluids Care Chronic diseases clinical implications diabetes displaying eye feature geometric Gout healthcare interstitial fluid management mechanisms noninvasive Parkinson’s disease Sweat
[DOI] 10.1038/s41427-020-00280-x [Article Type] Reviews

Itraconazole for COVID-19: preclinical studies and a proof-of-concept randomized clinical trial

COVID-19에 대한 이트라코나졸: 전임상 연구 및 개념 증명 무작위 임상 시험

Randomized Controlled Trial

Published on 2021-03-192022-08-13
Journal: EBioMedicine [Category] MERS, SARS, 비임상, 신약개발, 임상, 진단, 치료제,

[키워드] 7-point ordinal scale 95% CI absence acute infection acute SARS-CoV-2 infection adequate plasma antifungal drug itraconazole antivirals assigned breath Caco-2 clinical status Clinical studies clinical study clinical trial COVID-19 cumulative score did not reduce drug concentrations Drug repurposing effective evaluated finding foundation funding geometric Geometric means Health Organization Horizon hospitalized COVID-19 patient hospitalized COVID-19 patients human Caco-2 cells ileum in vitro activity initial interim analysis itraconazole Leuven lung Lungs Melinda Gate Melinda Gates not effective Open-label Ordinal Scale outcome Preclinical preclinical studies preclinical study premature termination Prevent prevention of COVID-19 Primary outcome proof-of-concept clinical study randomized clinical trial Randomly required SARS-CoV-2 SARS-COV-2 infection showed no signal single-center study Standard of care Stool stools Transmission Transmission model Treatment Vero Viral Viral load viral load in lungs Viral transmission World Health Organization
[DOI] 10.1016/j.ebiom.2021.103288 PMC 바로가기 [Article Type] Randomized Controlled Trial

Human Safety, Tolerability, and Pharmacokinetics of Molnupiravir, a Novel Broad-Spectrum Oral Antiviral Agent with Activity against SARS-CoV-2

Antiviral Agents

Published on 2021-03-012022-10-27
Journal: Antimicrobial Agents and Chemotherapy [Category] COVID-19,

[키워드] activity acute respiratory syndrome Administered administration adverse event agent Antiviral AUC C max clinically Concentration coronavirus COVID-19 declined decrease dose Dose escalation double-blind EIDD-1931 EIDD-2801 Electrocardiography evaluated exceeded expected first in human geometric healthy volunteers highest dose Human incidence influenza viruses Laboratory median time MERS-CoV Middle East Mild molnupiravir multiple dose multiple doses no decrease novel oral pandemic pharmacokinetics Phase 1 Placebo placebo-controlled study plasma plasma concentration Randomized Rash reached Registered reported respiratory syndrome coronavirus Ribonucleoside analog ribonucleoside analogue RNA viruses Safety SARS-CoV SARS-CoV-2 Serious Adverse Events single dose subject tested Tolerability vital signs
[DOI] 10.1128/AAC.02428-20 PMC 바로가기 [Article Type] Antiviral Agents

Newcastle Disease Virus-Like Particles Displaying Prefusion-Stabilized SARS-CoV-2 Spikes Elicit Potent Neutralizing Responses

Article

Published on 2021-01-212022-10-28
Journal: Vaccines [Category] COVID-19,

[키워드] antigenicity appear approach boost COVID-19 pandemic COVID-19 vaccine disease displaying dose ectodomain effective elicited ELISA geometric highlight immunization immunized mimicking morphology negative-stain electron microscopy neutralization neutralization titer Neutralizing activity neutralizing antibody newcastle disease virus Particle potent prefusion conformation prefusion-stabilized spike prime immunization response S-2P stabilization SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2-neutralizing antibody significantly higher spike Vaccine virus Virus-like particle virus-like particles VLP Week
[DOI] 10.3390/vaccines9020073 PMC 바로가기 [Article Type] Article

Analyzing the Impact of Vaccine Availability on Alternative Supplier Selection Amid the COVID-19 Pandemic: A cFGM-FTOPSIS-FWI Approach

Article

Published on 2021-01-132022-10-31
Journal: International journal for equity in health [Category] COVID-19,