Synergy of melanin and vitamin-D may play a fundamental role in preventing SARS-CoV-2 infections and halt COVID-19 by inactivating furin proteaseReview Published on 2020-11-052022-10-29 Journal: Translational Medicine Communications [Category] COVID-19, [키워드] Analysis approved binding Care cellular Control COVID-19 CYP27B1 drug ENhance enzyme expression furin FURIN expression furin protease Health host immunity humoral Immunity inactivation Infection management mechanism melanin Microbial melanin synthesis mortality rate pathway Prevent reduce regulate regulated SARS-CoV-2 SARS-COV-2 infection survival synergistic viral entry Vitamin D Vitamin-D [DOI] 10.1186/s41231-020-00073-y PMC 바로가기 [Article Type] Review
SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral responseArticle Published on 2020-10-272022-11-01 Journal: Cellular and Molecular Immunology [Category] COVID-19, MERS, SARS, [키워드] aggregation antiviral response cause downstream evade glycoprotein host immunity immune evasion innate immune response Innate immunity Interaction IRF3 M protein MAVS mechanism membrane Membrane glycoprotein M morbidity Mortality pathogen Pathways Protein recruitment SARS-CoV-2 SARS-related coronavirus TBK1 TRAF3 type I interferon [DOI] 10.1038/s41423-020-00571-x PMC 바로가기 [Article Type] Article
Clinical Impact Potential of Supplemental Nutrients as Adjuncts of Therapy in High-Risk COVID-19 for Obese PatientsNutrition Published on 2020-10-222022-10-31 Journal: Frontiers in Nutrition [Category] COVID-19, [키워드] acute respiratory syndrome adjunct boost caused China clinical clinical impact clinical trial Comorbidity coronavirus COVID-19 Cytokines disease effective global pandemic Health host immunity Impact Inflammation Intervention management Micronutrient micronutrients nutrient nutrition obese patients Potential reducing SARS-CoV-2 severity of symptom Standard therapy supportive care therapy Treatment viral infections [DOI] 10.3389/fnut.2020.580504 PMC 바로가기 [Article Type] Nutrition
Unique immunological profile in patients with COVID-19COVID-19 환자의 독특한 면역 프로필Clinical Trial Published on 2020-10-152022-08-13 Journal: Cellular and Molecular Immunology [Category] MERS, SARS, 바이오마커, 임상, 치료제, [키워드] (PD-1 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adaptive Analysis CD56 CD57 CD69 CD8 Cell contraction Coronavirus-2 COVID-19 COVID-19 patient Cytokines Deceased disease distribution driven by effective expansion expression FcεRIγ Frequency healthy subject healthy subjects help host immunity IL-1β IL-6 IL-8 IL6 immature immune response immune responses Immunoglobulin immunological profile Increased Infection Inflammatory cytokine Inflammatory cytokines interferon Interleukins lectin Lymphocytes monocyte Monocytes Monocytes and macrophages mucin natural killer NK cell NK cells NKG2D outcome overexpressed Patient patients with COVID-19 PD-1 performed Peripheral blood peripheral blood lymphocytes positive cell positive cells programmed cell death programmed cell death protein proportion Protein reduced respiratory restoration SARS-CoV-2 SARS-COV-2 infection secrete secreted secretion Serum level Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe COVID-19 severe SARS severe SARS-CoV-2 sialic acid Survivors T cell T cells T-cell TIM-3 Treatment unique viral infection with COVID-19 [DOI] 10.1038/s41423-020-00557-9 PMC 바로가기 [Article Type] Clinical Trial
COVID-19: Targeting Proteases in Viral Invasion and Host Immune ResponseMolecular Biosciences Published on 2020-10-092022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] absence accelerated ACE2 administration antiviral drug approach Cathepsins caused chemokine clinical evidence coronavirus COVID-19 cytokine globe help Host Host immune response host immunity immune reaction immune response immune system in viral Infection infections inflammatory cell information Invasion involved knowledge MERS Perspective plasma Predictive promoted protease protease inhibitors Proteases proteolytic Research respiratory disorder response SARS-CoV-2 SARS-CoV-2 viral severity Spread suggested target protease targeting therapeutic response TMPRSS2 tracing vaccination virus [DOI] 10.3389/fmolb.2020.00215 PMC 바로가기 [Article Type] Molecular Biosciences
Longitudinal Analysis of T and B Cell Receptor Repertoire Transcripts Reveal Dynamic Immune Response in COVID-19 PatientsImmunology Published on 2020-09-302022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Analysis applied avoidance B cell B cell receptor BCR Biomarker changes in convalescent stage COVID-19 COVID-19 infection Critical demonstrated Disease progression dynamic elevated event homeostasis host immunity IgA immune immune repertoire immunological implication Infection isotype switching longitudinal lymphocyte lymphopenia monitoring neutrophil Next-generation sequencing occurred polymerase chain predict question raise receptor repertoire response SARS-CoV-2 SARS-CoV-2 viral infection severe disease T cell T cell receptor TCR Therapies vaccination [DOI] 10.3389/fimmu.2020.582010 PMC 바로가기 [Article Type] Immunology
Selenium and selenoproteins in viral infection with potential relevance to COVID-19COVID-19와 잠재적 관련성이 있는 바이러스 감염의 셀레늄 및 셀레노단백질Review Published on 2020-09-102022-09-10 Journal: Redox Biology [Category] SARS, 치료제, [키워드] adaptive Adaptive immunity association benefit Chinese patient Chinese patients contribute Controlled trial COVID-19 COVID-19 patient COVID-19 patients COVID-19-associated inflammation Culture cure rate cytokine Cytokine activation doses Ebselen ENhance ER stress evade example explain expression functions Health Host host immunity host response hosts IL-6 immune response Immunity in viral incidence increased expression Infection inhibit SARS-CoV-2 inhibitor involved linear maturation mechanism mediator metabolite morbidity morbidity and mortality Pathogenesis pathogenic pharmacological play roles positive potential benefit potential benefits Prevent Proteases PROTECT Protective provide randomised rationale Recognition Redox-active selenium species reduced reducing required RNA SARS-CoV-2 SARS-CoV-2 infected cell SARS-CoV-2 infected cells SARS-COV-2 infection SARS-CoV-2 protease Selenium selenoprotein Selenoproteins serum sample serum samples severity significantly significantly higher Trace element Viral viral infections viral pathogenesis virus viruses with COVID-19 [DOI] 10.1016/j.redox.2020.101715 PMC 바로가기 [Article Type] Review
Severe immunosuppression and not a cytokine storm characterizes COVID-19 infectionsResearch Article Published on 2020-09-032022-10-30 Journal: JCI Insight [Category] COVID-19, SARS, [키워드] adaptive Adaptive immunity Administered Blood canonical COVID-19 COVID-19 infection COVID-19 infections COVID-19 patient COVID-19 patients Critically ill cytokine Cytokine storm diagnostic dissemination Elevation ELISPOT evaluate Ex vivo functional healthy control Host host immunity host response Hyperinflammatory hypothese Hypothesis IL-6 level IL-7 immune effector cell immune function immunoassay Immunosuppression immunosuppressive innate immune Innate immunity lack less monocyte mononuclear cell morbidity and mortality organ injury pathologic Patient patients patients with COVID-19 produced proinflammatory cytokines protective immunity reduced restored Sepsis stimulated Support suppresse T cell T cell subset Therapies TNF-α Volunteer [DOI] 10.1172/jci.insight.140329 PMC 바로가기 [Article Type] Research Article
Increased Proinflammatory Cytokine Production by Chronic Hepatitis B Patients with Mutant Hepatitis B Virus: Plausible Mechanisms Underlying Severe Liver Diseases in These PatientsArticle Published on 2020-09-012023-06-13 Journal: Viral immunology [Category] B형 간염, [키워드] Chronic Hepatitis B host immunity viral mutation [DOI] 10.1089/vim.2019.0198
The Virological, Immunological, and Imaging Approaches for COVID-19 Diagnosis and ResearchCOVID-19 진단 및 연구를 위한 바이러스학, 면역학 및 영상 접근 방식Review Published on 2020-08-182022-09-01 Journal: Slas Technology [Category] MERS, SARS, 바이오마커, 진단, 치료기술, [키워드] ACE2 affected angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 approach Biomarkers cellular receptor characterized Clinical characteristics Contact tracing contagious contagious disease Conventional COVID-19 COVID-19 diagnosis COVID-19 research Critical diagnostic diagnostics disease Early detection Extensive global pandemic globe highlight Horizon host immunity imaging immune microenvironment immunofluorescence immunohistochemistry immunological immunology Infection Isolation knowledge Laboratory laboratory-confirmed limitations monoclonal antibodies Novel coronavirus outbreak pathology Patient patients Pneumonia point-of-care Research respiratory respiratory illnesses SARS-CoV-2 SARS-CoV-2 vaccine specific T cells Spread Support tissue sample tissue samples Treatment used to evaluate Virological [DOI] 10.1177/2472630320950248 PMC 바로가기 [Article Type] Review