Immunogenicity of BNT162b2 Vaccine in Patients with Inflammatory Bowel Disease on Infliximab Combination Therapy: A Multicenter Prospective StudyArticle Published on 2021-11-182022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] age antibody azathioprine BNT162b2 clinical trial Combination combination therapy Concentration control group COVID-19 COVID-19 vaccination COVID-19 vaccine dose evaluate excluded group healthy IBD IgA IgA level IgA levels IgG immunogenicity Inflammatory bowel disease infliximab IQR median mRNA vaccine multicenter neutralizing antibody of BNT162b2 outcomes participant Participants Patient patients treated percentage positive Primary outcome Prospective Prospective Study PROTECT receiving recruited SARS-CoV-2 antibody SARS-CoV2 seroconverted Serologic response Sex significantly lower study group the study group the vaccine vaccination Vaccine [DOI] 10.3390/jcm10225362 PMC 바로가기 [Article Type] Article
Vaccination against SARS-CoV-2 in Patients with Inflammatory Bowel Diseases: Where Do We Stand?Review Published on 2021-11-112022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] acute respiratory distress acute respiratory syndrome approach ARDS circulation Complication coronavirus disease Coronavirus-2 Course COVID-19 Crohn’s disease Crohn’s disease effective Effectiveness expected gastrointestinal tract greater IBD Immunocompromised immunological immunosuppressive therapies immunosuppressive therapy Infection Inflammation Inflammatory bowel disease knowledge management medication pandemic pathogen Pathogens Patient patients provide reducing risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination severe disease course shown subject syndrome Therapeutic approach ulcerative colitis underlying condition vaccination Vaccine vaccine response [DOI] 10.3390/life11111220 PMC 바로가기 [Article Type] Review
The Impact of Vedolizumab on COVID-19 Outcomes Among Adult IBD Patients in the SECURE-IBD RegistrySECURE-IBD 레지스트리에서 성인 IBD 환자의 COVID-19 결과에 대한 베돌리주맙의 영향Article Published on 2021-11-082022-09-12 Journal: Journal of Crohn's & colitis [Category] MERS, SARS, 진단, [키워드] 95% CI 95% confidence interval adjusted odds ratio anti-TNF appear bowel Care comparable coronavirus disease Coronavirus disease 2019 covariates COVID-19 COVID-19 hospitalization Crohn’s disease determine Exploratory analysis Gastrointestinal symptom Hospitalization IBD Impact Inflammatory bowel disease International mechanical ventilation medication monotherapy multivariable analysis Necrosis outcome outcomes Patient patients patients with COVID-19 registry Safe severe COVID-19 Therapies therapy ulcerative ulcerative colitis vedolizumab [DOI] 10.1093/ecco-jcc/jjab071 PMC 바로가기 [Article Type] Article
Lower incidence of COVID-19 in patients with inflammatory bowel disease treated with non-gut selective biologic therapyObservational Study Published on 2021-11-012022-10-05 Journal: Journal of gastroenterology and hepatology [Category] SARS, 임상, [키워드] biologic biologic agent Biologic therapy bowel Clinical outcome Cohort collected data COVID-19 COVID-19 symptom cumulative determine General population higher risk Hospitalization IBD incidence incidence of COVID-19 Inflammatory bowel disease Italy large cohort lombardy Lower outbreak outcome Patient patients raised Retrospective multicenter study risk factor SARS-CoV-2 selective susceptible symptomatic disease Symptoms the disease Therapies therapy treated Treatment [DOI] 10.1111/jgh.15591 PMC 바로가기 [Article Type] Observational Study
Intestinal Protein Characterisation of SARS-CoV-2 Entry Molecules ACE2 and TMPRSS2 in Inflammatory Bowel Disease (IBD) and Fatal COVID-19 InfectionOriginal Article Published on 2021-10-252022-10-30 Journal: Inflammation [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] ACE2 age analysed characterisation Colon colonic contribute controls coronavirus SARS-CoV-2 COVID-19 COVID-19 cohort Crohn’s disease Crohn’s disease cytoplasmic dataset enterocytes Evidence expressed expression fatal COVID-19 Frequency Gut gut biology histologic histology IBD ileal Immune cell immune response Inflammation Inflammatory bowel disease intestinal lamina propria Lungs membrane molecule morbidity and mortality mucosa Multiple myeloma no difference Patient Plasma cell Plasma cells Protein provide recent Regulatory SARS-CoV-2 SARS-COV-2 infection shown significantly higher staining staining intensity supplementary material tissue expression TMPRSS2 TMPRSS2 expression UC ulcerative colitis viral tropism widespread [DOI] 10.1007/s10753-021-01567-z PMC 바로가기 [Article Type] Original Article
Impairment of CD4+ T and Memory B Cell Responses but Normal Memory CD8+T-Cell Activation on Crohn’s Disease after COVID-19 Vaccination: A Twin CaseCommunication Published on 2021-10-242022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] Activation Antibody detection antibody production Autoimmune disease Autoimmune diseases CD4+ CD4+ T cell CD8+ T-cell cellular cellular response central memory comparison Consensus COVID-19 COVID-19 vaccination COVID-19 vaccines Crohn’s disease Crohn’s disease evaluated had no humoral humoral immune responses IBD IFNγ immunization Inflammatory bowel disease infliximab information lack monozygotic twin normal observation Patient Prevent receive reduced response responses SARS-CoV-2 second dose Support T-cell immunity treated Treatment twin vaccination Vaccine [DOI] 10.3390/v13112143 PMC 바로가기 [Article Type] Communication
Seroconversion Following SARS-CoV-2 Infection or Vaccination in Pediatric IBD Patients소아 IBD 환자에서 SARS-CoV-2 감염 또는 백신 접종 후 혈청전환Article Published on 2021-10-202022-09-12 Journal: Inflammatory bowel diseases [Category] MERS, SARS, 진단, [키워드] Abstract antibody bowel COVID-19 Crohn’s disease IBD IBD-unspecified Inflammatory Inflammatory bowel disease pediatric SARS-CoV-2 SARS-CoV2 ulcerative ulcerative colitis vaccination [DOI] 10.1093/ibd/izab194 PMC 바로가기 [Article Type] Article
A Patient-Prioritized Agenda for Information Needs During the COVID-19 Pandemic: A Qualitative Study of Patients With Inflammatory Bowel DiseaseObservations and Research Published on 2021-10-192022-11-01 Journal: Crohn's & Colitis 360 [Category] COVID-19, [키워드] Analysis analyzed coded Complication conducted COVID-19 COVID-19 complications COVID-19 pandemic COVID-19 vaccination Crohn’s disease finding Focus groups group groups healthcare IBD Identified identify Inflammatory bowel disease information initial medication medications pandemic participant Participants Patient patients performed preferences Qualitative question Research Research question Result risk ulcerative colitis worsening [DOI] 10.1093/crocol/otab066 PMC 바로가기 [Article Type] Observations and Research
The COVID-19 Vaccination Hesitancy Among the People With Inflammatory Bowel Disease in China: A Questionnaire StudyPublic Health Published on 2021-10-112022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] Adverse reactions China Complete concerning COVID-19 COVID-19 vaccination COVID-19 vaccine Efficacy Efficacy and safety evaluate facilitate Health Health Education Hesitancy IBD immunocompromised population immunosuppressants independent individuals Inflammatory bowel disease participant Participants Patient Perspective questionnaire reliability Safety SARS-CoV-2 vaccination significantly Therapies vaccination Willingness women [DOI] 10.3389/fpubh.2021.731578 PMC 바로가기 [Article Type] Public Health
Severe COVID-19 in inflammatory bowel disease patients in a population-based settingResearch Article Published on 2021-10-052022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] 95% CI Admission affected age BMI Clinical course comparable confidence Course COVID-19 COVID-19 patient Crohn’s disease death determine Follow-up General population hospital Hospitalization Hospitalized hospitalized patient IBD ICU admission impacted incidence rate increased risk Infection Inflammatory bowel disease IQR mechanical ventilation Netherlands objective Patient populations reflect Research Result severe COVID-19 statistically significant systemic medication ulcerative colitis [DOI] 10.1371/journal.pone.0258271 PMC 바로가기 [Article Type] Research Article