In Vitro Replication Inhibitory Activity of Xanthorrhizol against Severe Acute Respiratory Syndrome Coronavirus 2Article Published on 2021-11-192022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] 3CL activity acute respiratory syndrome Antiviral Antiviral effect antiviral efficacy Cell clade clinical trial coronavirus coronavirus 2 Coronaviruses CoV replication COVID-19 pandemic CoVs Curcuma direct-acting antiviral drug enzymatic activity function had no Helicase hepatitis C virus herbal medicine human coronavirus in vitro Infection inhibit inhibited inhibitory management mechanism noroviruses pan-coronavirus antivirals polymerase predominant protease reduced Replication respiratory RNA SARS-CoV-1 SARS-CoV-2 therapeutic option variants variants of concern Viral RNA while xanthorrhizol [DOI] 10.3390/biomedicines9111725 PMC 바로가기 [Article Type] Article
NK and T Cell Immunological Signatures in Hospitalized Patients with COVID-19COVID-19로 입원한 환자의 NK 및 T 세포 면역학적 특징Article Published on 2021-11-152022-09-11 Journal: Cells [Category] MERS, SARS, 치료기술, 치료제, [키워드] Activation acute respiratory syndrome analysed caused CD16 CD25 CD56 CD69 China Clinical severity Concentration control groups coronavirus coronavirus 2 correlation COVID-19 COVID-19 infection COVID-19 patient cytokine cytokine release Cytokines cytomegalovirus died Direct enrolled flow cytometry Frequency healthy subject hospitalised patient human population IL-6 immune response immunology increase in inhibitory involved lung transplant maintain Mild moderate modulate Multiplex assay NK cell NK cells NKG2A overexpression Patient patients with COVID-19 PD-1 phenotype progression reported respiratory SARS-COV-2 infection serum serum cytokines Severe acute respiratory syndrome severe COVID-19 patients severe disease signature significantly higher Stimulation stratified subset Survivors T cell T cell subset T cells T-cell responses targeted therapy Viral viral infections with COVID-19 Wuhan [DOI] 10.3390/cells10113182 PMC 바로가기 [Article Type] Article
Intrathecal inflammatory responses in the absence of SARS-CoV-2 nucleic acid in the CSF of COVID-19 hospitalized patientsCOVID-19 입원 환자의 뇌척수액에서 SARS-CoV-2 핵산이 없을 때 척수강내 염증 반응Article Published on 2021-11-152022-09-11 Journal: Journal of the neurological sciences [Category] SARS, 변종, 치료기술, [키워드] absence acute COVID-19 albumin associations Atypical Blood Blood brain barrier cell count cerebrospinal fluid chemokine chemokines consecutive patient Control correlated COVID-19 COVID-19 patient COVID-19 patients Cryptococcus neoformans CSF Cytokines detectable evidence of healthy control HIV HIV-1 hospitalized patient IL-15 IL-6 IL-8 Infection Inflammation Inflammatory cytokine Inflammatory cytokines Inflammatory response inhibitory Intrathecal marker MCP-1 metagenomic sequencing MIP-1β monocyte Neurological symptom Neurological symptoms NEUROLOGY neurotropic pathogen Pathogens Patient patients patients with COVID-19 performed pleocytosis profile proinflammatory Proinflammatory cytokine proinflammatory cytokines Protein Quantitative reverse transcription PCR RT-qPCR SARS-CoV-2 nucleic acid SARS-CoV-2 RNA Sequencing subset suppressed two patients was tested were infected West Nile Virus White blood cell with COVID-19 [DOI] 10.1016/j.jns.2021.120023 PMC 바로가기 [Article Type] Article
Molecular docking and pharmacokinetic studies of phytocompounds from Nigerian Medicinal Plants as promising inhibitory agents against SARS-CoV-2 methyltransferase (nsp16)Research Published on 2021-11-092022-10-30 Journal: Journal of Genetic Engineering & Biotechnology [Category] COVID-19, [키워드] Anacardium Analysis binding affinity Cell cells China circulation COVID-19 Crinum death docking docking score dose drug design drug-likeness Efficacy identify in silico in vitro in vivo index case inhibit SARS-CoV-2 inhibitory inhibitory activity Innate immunity Ligand mechanisms methyltransferase Molecular docking study molecular target more difficult nsp16 performed pharmacokinetic pharmacokinetics Phytocompounds plant Prevent quercetin Replication reported Result Salvia officinalis SARS-CoV-2 SARS-CoV-2 viral RNA stability supplementary material survival therapeutic agent unique Vaccine variants of SARS-CoV-2 virulent virus detection [DOI] 10.1186/s43141-021-00273-5 PMC 바로가기 [Article Type] Research
Assessing sensitivity and reproducibility of RT-ddPCR and RT-qPCR for the quantification of SARS-CoV-2 in wastewater폐수 내 SARS-CoV-2 정량을 위한 RT-ddPCR 및 RT-qPCR의 감도 및 재현성 평가Article Published on 2021-11-012022-09-11 Journal: Journal of virological methods [Category] SARS, 치료기술, 치료법, [키워드] Analysis analytical sensitivity analyzed Assessing Beach calculated Chapel city common Community comparison component Concentration conducted controls Correlation analysis COVID-19 demonstrated detection Dilution District global pandemic greater group Hill implementation IMS indicated Infection influent inhibitory Investment limit limits molecular methods nine North nucleic acid nucleocapsid protein PCR plant positive positive correlation primer probe quantification reagents reproducibility road RT-qPCR Sample Sanitation SARS-CoV-2 Science sensitivity significantly standardized protocol standardized protocols Surveillance Template Treatment Viral load viral loads viral pathogen Virginia wastewater [DOI] 10.1016/j.jviromet.2021.114230 PMC 바로가기 [Article Type] Article
Cross-neutralization of RBD mutant strains of SARS-CoV-2 by convalescent patient derived antibodies회복기 환자 유래 항체에 의한 SARS-CoV-2의 RBD 돌연변이 균주의 교차 중화Article Published on 2021-11-012022-09-11 Journal: Biotechnology Journal [Category] MERS, SARS, 변종, 진단, [키워드] 293T cells ACE2 angiotensin angiotensin converting enzyme antibody Bin2 binding binding affinity Cell clone clones convalescent patient COVID-19 pandemic COVID-19 recovered patient enzyme epitope global pandemic group hACE2 high affinity IgG inhibitory Interaction live SARS-CoV-2 MOST mutant mutant strain mutants mutations N501Y neutralized Neutralizing Neutralizing antibodies neutralizing antibody overexpressed patient-derived antibody libraries. positive preventing infection pseudovirus entry RBD RBDs receptor Receptor binding domain SARS-CoV-2 SARS-CoV-2 strain screened spike Spike protein the antibody therapeutic interventions V367F Vero-E6 cells Viral viral infection wildtype [DOI] 10.1002/biot.202100207 PMC 바로가기 [Article Type] Article
Identification of nut protein-derived peptides against SARS-CoV-2 spike protein and main proteaseSARS-CoV-2 스파이크 단백질 및 메인 프로테아제에 대한 견과류 단백질 유래 펩타이드 동정Article Published on 2021-11-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 치료제, [키워드] addition Amino acid amino acid residue amino acid residues assist binding affinities binding affinity binding site coronavirus coronavirus disease COVID-19 COVID-19 patients develop domain effective Entry inhibitor entry inhibitors evaluated exhibited identification in silico inhibitor inhibitor N3 inhibitory M pro molecular docking molecular dynamics Molecular dynamics simulation Novel coronavirus novel coronavirus disease Nut proteins outbreak pandemic peanuts peptide peptides proportions protease Protein RBD reached SARS-CoV-2 SARS-COV-2 M(pro) SARS-CoV-2 main protease SARS-CoV-2 spike protein SARS-CoV-2 Spike RBD SARS-CoV-2 spike RBD. screened Spike protein target the SARS-CoV-2 the spike protein Treatment [DOI] 10.1016/j.compbiomed.2021.104937 PMC 바로가기 [Article Type] Article
Safety, reactogenicity, and immunogenicity of homologous and heterologous prime-boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort studyChAdOx1 nCoV-19 및 BNT162b2를 사용한 동종 및 이종 프라임-부스트 면역의 안전성, 반응성 및 면역원성: 전향적 코호트 연구Observational Study Published on 2021-11-012022-09-11 Journal: The Lancet. Respiratory Medicine [Category] MERS, SARS, 변종, 임상, 진단, [키워드] 95% CI Alpha anti-RBD Anti-RBD IgG Anti-S1 AstraZeneca B.1.1.7 B.1.351 Berlin Beta Beta variant beta variants binding BNT162b2 boost booster Cambridge ChAdOx1 ChAdOx1 nCoV-19 Concentration COVID-19 COVID-19 vaccines Cutoff dose education enrolled geometric mean Germany health-care Heterologous heterologous prime-boost highest homologous IFN-γ IgG levels immunisation immunogenicity IMPROVE inhibitory interim analysis IQR Mainz median mitigate neutralisation test participant Pfizer-BioNTech prospective cohort study prospective observational cohort pseudovirus neutralisation assay questionnaire RBD IgG RBD-ACE2 reactivity reactogenicity receiving recipient recipients regimen reported Safety SARS-CoV-2 S1 SARS-CoV-2 virus SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody second vaccination specific antibodies supply shortage Symptom systemic systemic symptoms T-cell vaccination Vaccine variants of concern was measured [DOI] 10.1016/S2213-2600(21)00357-X PMC 바로가기 [Article Type] Observational Study
Single domain shark VNAR antibodies neutralize SARS-CoV-2 infection in vitro단일 도메인 상어 VNAR 항체는 시험관 내에서 SARS-CoV-2 감염을 중화합니다Article Published on 2021-11-012022-09-11 Journal: FASEB journal : official publication of the Federa [Category] MERS, SARS, 변종, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus addition angiotensin angiotensin-converting enzyme 2 antibodies antibody Antigen antigen receptor approach binding blocking activity Cell clone coronavirus COVID-19 COVID-19 disease disease domain E484K epitope exhibited expressing flexibility high affinity in vitro infectivity assays inhibitory monoclonal antibodies monoclonal antibody mutant N501Y neutralize Neutralizing neutralizing antibody offer pandemic receptor Receptor binding domain respiratory retained SARS-CoV-2 SARS-COV-2 infection selected severe acute respiratory syndrome Coronavirus single domain antibody. specificity Spike protein Spike protein receptor binding domain tested the spike protein treat treating COVID-19 unique variant Viral virus VNAR was used Wuhan [DOI] 10.1096/fj.202100986RR PMC 바로가기 [Article Type] Article
Whey-Derived Peptides at the Heart of the COVID-19 PandemicCOVID-19 팬데믹의 중심에 있는 유청 유래 펩타이드Article Published on 2021-10-282022-09-10 Journal: International Journal of Molecular Sciences [Category] 치료제, [키워드] ACE ACE inhibitor ACE inhibitors ACE inhibitory activity ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 approach association blood pressure blood pressure homeostasis Captopril cells component coronavirus COVID-19 COVID-19 pandemic drugs dual enzyme exhibiting heart human ACE2 hypertension inhibit inhibitory inhibitory action inhibitory activity IPP Lisinopril molecular docking molecular interaction peptide peptide sequences peptides Previous studies produced RAS RAS inhibitor RAS inhibitors receptor reduced risk renin–angiotensin system renin–angiotensin system reported respiratory SARS-CoV-2 sequence severe acute respiratory syndrome Coronavirus shown synthetic drugs therapeutic Treatment treatment of COVID-19 were assessed whey peptides [DOI] 10.3390/ijms222111662 PMC 바로가기 [Article Type] Article