Coronavirus disease 2019 and pityriasis rosea: A review of the immunological connectionReview Published on 2022-10-012023-07-09 Journal: The Journal of dermatology [Category] COVID19(2023년), [키워드] Cytokine storm immune system interferon pandemic respiratory infection pityriasis rosea severe acute respiratory syndrome coronavirus 2 T cells T-helper 17 Telemedicine viral reactivation [DOI] 10.1111/1346-8138.16482 PMC 바로가기 [Article Type] Review
Pernio and early SARS-CoV-2 variants: natural history of a prospective cohort and the role of interferonArticle Published on 2022-10-012022-11-15 Journal: The British journal of dermatology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] Cohort COVID-19 interferon Madison mean temperature pernio prospective cohort SARS-CoV-2 [DOI] 10.1111/bjd.21693 PMC 바로가기
Innate Immune Response and Inflammasome Activation During SARS-CoV-2 InfectionArticle Published on 2022-10-012022-11-15 Journal: Inflammation [Category] COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] Activation Antiviral characterized Clinical outcome COVID-19 COVID-19 outbreak Defense develop drug Effect evade flexibility Genome human pathogen IL-18 IL-1β IL-6 immune immune response immunopathology implicated IMPROVE Infection infective Inflammasome inflammasome pathway inflammatory disease inhibiting Innate innate immune response innate immune system interferon Intervention mutant strain NLRP3 novel coronavirus SARS-CoV-2 pandemic pathology Predictive preventive measure pro-inflammatory cytokine promote protective role public health receptor Replication response responsible RNA virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 shown the interferon treating COVID-19 Trigger urgent investigation Vaccine vaccine candidate vaccine candidates vaccine for COVID-19 viral disease viral evolution virus viruses [DOI] 10.1007/s10753-022-01651-y PMC 바로가기
SARS-CoV-2 variants Alpha, Beta, Delta and Omicron show a slower host cell interferon response compared to an early pandemic variantArticle Published on 2022-09-302022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 치료제, [키워드] Activation analyzed antiviral response arising Beta Calu-3 cell calu-3 cells cellular circumvent comparable replication correlated COVID-19 infection Delta Effect epithelial Evolution genomic host cell human lung Immunity induce innate immune innate immune activation Innate immunity interferon interferon response ISG ISGs mRNA expression Mutation mutations omicron pandemic produced Replication replication efficiency SARS-CoV-2 SARS-CoV-2 variant signaling pathways STAT2 stimulated Transmission Treatment vaccination Vaccine variant variants variants of concern variations Viral RNA virus virus replication while [DOI] 10.3389/fimmu.2022.1016108 PMC 바로가기
Vitamin D Supplementation Does Not Influence SARS-CoV-2 Vaccine Efficacy or Immunogenicity: Sub-Studies Nested within the CORONAVIT Randomised Controlled TrialArticle Published on 2022-09-162022-11-15 Journal: Nutrients [Category] SARS, 진단, [키워드] 25-hydroxyvitamin D 95% CI Acute respiratory infection adjusted hazard ratio antibody baseline blood sample BNT162b2 BNT162b2 Pfizer boost Breakthrough SARS-CoV-2 infection cellular response ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 Oxford–AstraZeneca circulating collected Concentration concentrations Controlled deficiency determine dose dried blood spot Effect Efficacy elevated Follow-up IFN-γ IgA IgG IgM influence interferon interferon gamma investigated mean difference neutralising antibody neutralising antibody titre of BNT162b2 offer participant Pfizer Protective randomised controlled randomised controlled trial reported response risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination SARS-CoV-2 vaccine significantly supernatant titre titres vaccination venous Vitamin Vitamin D Vitamin D status vitamin D supplement Vitamin D supplementation Whole blood [DOI] 10.3390/nu14183821 PMC 바로가기
Multiomics approach reveals the ubiquitination-specific processes hijacked by SARS-CoV-2Article Published on 2022-09-072022-11-15 Journal: Signal Transduction and Targeted Therapy [Category] SARS, 유전자 메커니즘, 치료제, [키워드] activated addition Analysis Anti-inflammation Antiviral antiviral drug approach caused conducted coronavirus 2 COVID-19 disrupting E3 ligase E3 ubiquitin ligase effective ENhance enzyme global pandemic Health highlighting Host Infection Inflammatory responses innate immune response Innate immunity interferon lung epithelial cell Lung epithelial cells mechanism modulate multiomics pathogenesis of SARS-CoV-2 promote Protein proteomic respiratory reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein significantly Spread targets the epidemic the Spike therapeutic targets transcriptomic Vaccine viral infection [DOI] 10.1038/s41392-022-01156-y PMC 바로가기
mRNA-LNP vaccines tuned for systemic immunization induce strong antitumor immunity by engaging splenic immune cellsArticle Published on 2022-09-072022-11-16 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] antibody antigen-presenting cells appear B cell biodistribution Cancer Cancer vaccine CD8 T cell changes in Clinical studies design-of-experiments methodology effective extrahepatic delivery histopathological Immune cell immune cell populations Immunity immunization Immunotherapy induce interferon liver LNP mechanism methodology mRNA mRNA expression non-human primate phagocyte provide response responses SARS-CoV-2 spleen stimulatory systemic T cell T cell response the vaccine Type vaccination Vaccine [DOI] 10.1016/j.ymthe.2022.07.007 PMC 바로가기
Autoantibodies elicited with SARS-CoV-2 infection are linked to alterations in double negative B cellsArticle Published on 2022-09-052022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] Activation alteration antibodies autoantibodies autoantibody Autoimmune disease autoreactive autoreactive antibody B cell B cells BCR Cell changes in characterized CRP described DN1 DN2 DN3 DN3 cells DN4 double negative elevated elicited Frequency functional heterogenous IFNγ IL-1β IL-6 Immunoglobulin increase increase in Infection Inflammation interferon negative precursor pro-inflammatory cytokine reduction in reported SARS-COV-2 infection SARS–CoV–2 secreting cell serum Severe infection severe SARS-CoV-2 Signaling significantly subset systemic inflammation systemic level TNFα viral infection [DOI] 10.3389/fimmu.2022.988125 PMC 바로가기
Impaired activation of transposable elements in SARS-CoV-2 infectionArticle Published on 2022-09-052022-11-15 Journal: EMBO Reports [Category] SARS, 유전자 메커니즘, 치료제, [키워드] activate activated Activation Cell cellular changes in Chromatin structure correlation COVID-19 Defense drug target element elements Epigenetic epigenetics Evidence explain expression expression level functional Genes Host host immune system identify immune Impaired Infection interferon interferon response mechanism primary cells Proteins provide regulate robust SARS-CoV-2 SARS-COV-2 infection suggested the SARS-CoV-2 Transcription transposable elements. upregulation variable viral infections Viral load viruses [DOI] 10.15252/embr.202255101 PMC 바로가기
In vitro and in vivo differences in neurovirulence between D614G, Delta And Omicron BA.1 SARS-CoV-2 variantsArticle Published on 2022-09-052022-11-16 Journal: Acta Neuropathologica Communications [Category] SARS, 변종, [키워드] acute phase acute respiratory syndrome astrocytes B.1.1.529 B.1.617.2 Brain olfactory bulb Cell CNS co-cultured coronavirus cortical COVID-19 Culture D614G days post infection Delta hamster hamsters in vitro in vivo in vivo models Infection inoculated interferon isolate mechanism microglia activation mucosa Neuroinflammation neuroinvasion Neuroinvasive Neurological complications Neuron neurotropic neurotropism neurovirulence neurovirulent occur olfactory omicron performed reduced SARS-CoV-2 SARS-CoV-2 variant shown the SARS-CoV-2 variant [DOI] 10.1186/s40478-022-01426-4 PMC 바로가기