Footprint of the COVID-19 Pandemic in India: A Study of Immune Landscape and Other Factors Shielding MortalityReview Article Published on 2020-12-242022-10-28 Journal: Analytical Cellular Pathology (Amsterdam) [Category] COVID-19, Fulltext, MERS, SARS, [키워드] affected age BCG vaccination CD4 CD8 Cell contribute COVID-19 Cytotoxic T cell Ethnic groups expressed Factor favor Footprint genetic architecture Health HLA HLA ligand human leukocyte antigen immune response gene Immunity India infected cell infected cells Infection infection rates KIR KIR-HLA landscape Mortality motif natural killer NK cell function Other outbreak overexpressed pandemic polymorphism preventive measure receptor SARS-CoV-2 shown significantly significantly lower survival T cell T cells target the SARS-CoV-2 therapeutic intervention triggering Vaccination strategies virus-infected cell [DOI] 10.1155/2020/6692739 PMC 바로가기 [Article Type] Review Article
Class I HLA Allele Predicted Restricted Antigenic Coverages for Spike and Nucleocapsid Proteins Are Associated With Deaths Related to COVID-19클래스 I HLA 대립유전자 예측 스파이크 및 뉴클레오캡시드 단백질에 대한 제한된 항원 범위는 COVID-19와 관련된 사망과 관련되어 있습니다Immunology Published on 2020-12-162022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 치료법, [키워드] addition allele frequency Amino acid analyzed Antigen antigens approach association best Betacoronavirus class Clustering contribute coronavirus coronavirus strains correlated country Coverage COVID-19 death distribution elevated epidemiological data etiological agent frequencies herd immunity HLA HLA allele HLA alleles HLA-A HLA-B Immunity in silico insertion knowledge landscape ligandome lowest mortality rate mortality rates not affect number of deaths outcome Pandemics peptide peptides population coverage analysis potential risk predicted respond Restricted SARS-CoV-2 severity spike Spread spread to the disease These data Vaccine with COVID-19 [DOI] 10.3389/fimmu.2020.565730 PMC 바로가기 [Article Type] Immunology
Drug Repurposing for Prevention and Treatment of COVID-19: A Clinical LandscapeReview Article Published on 2020-12-162022-11-01 Journal: Discoveries [Category] COVID-19, [키워드] accelerate accumulate addition affected approval approved candidate caused clinical clinical trial clinically coronavirus COVID-19 COVID-19 patient COVID-19 vaccine distribution drug drug repositioning Effect effective expected FDA help Infection information lack landscape Mutation Novel coronavirus outbreak pandemic pandemic of COVID-19 phases Potential treatment prevention Remdesivir repurposing Research resource respond responsible SARS-CoV-2 suggested Therapeutics therapy treat Treatment USA Vaccine Vaccines viral infection virus [DOI] 10.15190/d.2020.18 PMC 바로가기 [Article Type] Review Article
CO1 Mapping The Landscape Of Covid-19 Clinical Trials In The US: Assessing The Opportunities And Gaps In Trial Designs, Interventions And EndpointsConference abstract Published on 2020-12-012022-10-05 Journal: Value in health : the journal of the International [Category] 임상, [키워드] Assessing clinical Gap landscape mapping opportunity [DOI] 10.1016/j.jval.2020.08.016 [Article Type] Conference abstract
Pervasive generation of non-canonical subgenomic RNAs by SARS-CoV-2SARS-CoV-2에 의한 비정규 서브게놈 RNA의 광범위한 생성Research Published on 2020-12-012022-08-13 Journal: Genome Medicine [Category] MERS, SARS, 유전자 메커니즘, [키워드] 3′ end 5′ UTR abundance accessory protein addition Analysis approaches canonical canonical sgRNA canonical sgRNAs caused Cell culture condition Consistency Coordinate coronavirus disease Coronavirus disease 2019 Coverage COVID-19 determine Direct RNA sequencing eight Evidence family Coronaviridae FIVE generate Genome highlight homology Host identify in viral increase in independent Infection information Integrative analysis junction landscape leader sequence make up nc-sgRNA nc-sgRNAs non-canonical sgRNA non-canonical sgRNAs non-canonical subgenomic RNA offer open reading frames ORF ORF1a ORFs positive-sense RNA virus Region reported Result RNA RNA virus SARS-CoV-2 SARS-CoV-2 biology SARS-CoV-2 genome SARS-CoV-2 pathogenesis SARS-CoV-2 RNA SARS-CoV-2 sgRNA SARS-CoV-2 sgRNAs SARS-CoV-2 transcriptome SARS-CoV-2 transcriptomes sequence sequences Sequencing Seven sgRNA sgRNAs subgenomic RNA subgenomic RNAs supplementary material the SARS-CoV-2 genome Transcription transcriptional activity transcriptional regulatory sequence transcriptional regulatory sequences transcriptomes TRS TRS-B TRS-L Viral viral isolate viral isolates viral RNAs was used worldwide pandemic [DOI] 10.1186/s13073-020-00802-w PMC 바로가기 [Article Type] Research
The Landscape of Coronavirus Disease 2019 (COVID-19) and Integrated Analysis SARS-CoV-2 Receptors and Potential Inhibitors in Lung Adenocarcinoma PatientsCell and Developmental Biology Published on 2020-10-232022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] AAK1 ACE2 addition adenocarcinoma anti-inflammatory effect B cell bioinformatic analysis Cancer patients CD4 T cells Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 patient death differentially expressed gene Effect endocytic explain expression Factor Health immune Immune cell immune infiltration infiltration Inflammation involved landscape lung adenocarcinoma lung adenocarcinoma (LUAD) malignant tumors novel coronavirus disease outbreak Patient positive Potential Prognosis Regulation SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) signaling pathways significantly significantly increased susceptibility susceptible the patient TMPRSS2 Treatment [DOI] 10.3389/fcell.2020.577032 PMC 바로가기 [Article Type] Cell and Developmental Biology
A new domestic cat genome assembly based on long sequence reads empowers feline genomic medicine and identifies a novel gene for dwarfism긴 서열 판독을 기반으로 한 새로운 국내 고양이 게놈 어셈블리는 고양이 게놈 의학에 힘을 실어주고 왜소증에 대한 새로운 유전자를 식별합니다Research Article Published on 2020-10-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] aligned allele analyses Analysis Author Biology Biosynthesis Cancer candidate cats chromosome complex correlated Deleterious disease distribution duplication dwarfism expansion facilitate FBXW7 Felis framework Genome genome assembly genomic genomic variation Glucose Health help Households human gene Human genetics humans identify Impact IMPROVE information involved landscape lead Lineage lymphoma Mutation mutations nucleotide patients phenotype Phenotypes predicted rare diseases reference genome resource screened sequence sequence variation significantly Single nucleotide variant single nucleotide variants SNV SNVs Structural variant structural variants susceptibility SVs Tumor tumor suppressor UGDH USA utility variant Variation whole genome sequence [DOI] 10.1371/journal.pgen.1008926 PMC 바로가기 [Article Type] Research Article
Single-Cell RNA Sequencing Reveals the Diversity of the Immunological Landscape following Central Nervous System Infection by a Murine CoronavirusPathogenesis and Immunity Published on 2020-09-302022-10-30 Journal: Journal of Virology [Category] Coronavirus, [키워드] Adaptive immune response addition Analysis Antiviral approach Brain C57BL/6 CD45 Cell cellular pathway Central nervous system Central nervous system infections CNS contributing to coronavirus Critical Defense defined Demyelination disease Diversity effective evaluate expressed expressing heterogeneity Host host defense identify Immune cell immune response Immune-mediated immunological immunological mechanism immunology infecting Infection Intracranial involved landscape macrophages mice microglia molecular molecular network mouse hepatitis virus mRNA expression profile murine nervous nervous system Neuroimmunology neurologic neurotropic pathway RNA scRNAseq Single-cell RNA sequencing Stage subset susceptible System the Coronaviridae understanding unique viral infection viral persistence viral replication virus [DOI] 10.1128/JVI.01295-20 PMC 바로가기 [Article Type] Pathogenesis and Immunity
ACE2 Protein Landscape in the Head and Neck Region: The Conundrum of SARS-CoV-2 InfectionArticle Published on 2020-08-182022-10-28 Journal: Biology [Category] COVID-19, [키워드] absence ACE2 ACE2 expression acute respiratory syndrome angiotensin-converting enzyme 2 antibody caused coronavirus cytoplasmic domain epithelial cells expression Extracellular head head and neck highlight histological human cell immunohistochemistry Infection Interpretation labeling landscape monoclonal antibody Neck organs pandemic paraffin-embedded polyclonal Protein protein expression provide quantified raised receptor reported salivary gland SARS-CoV-2 specimen the SARS-CoV-2 [DOI] 10.3390/biology9080235 PMC 바로가기 [Article Type] Article
Protein Coding and Long Noncoding RNA (lncRNA) Transcriptional Landscape in SARS-CoV-2 Infected Bronchial Epithelial Cells Highlight a Role for Interferon and Inflammatory ResponseArticle Published on 2020-07-072022-10-31 Journal: Genes [Category] COVID-19, SARS, [키워드] activated Activation acute inflammatory response acute respiratory syndrome Analysis Antiviral antiviral response bioinformatics Biomarkers bronchial bronchial epithelial bronchial epithelial cell category caused Cell cell death cells Community coronavirus Course COVID-19 differentially expressed disease expressed gene expression functional functional annotation gene expressions gene target hallmark highlight host cells host response Ifi44 IFI44L IFIT1 IFIT2 IFIT3 IFITM1 IFN IFN response IgG immune response Immunoglobulin in vitro induction Infection innate response interferon Interferon lambda investigated involved IPA IRF9 landscape lncRNA lncRNAs Long long noncoding RNA lung tissue MAPK MX1 Necrosis network analysis NHBE OAS2 OAS3 Ontology pathogenesis of COVID-19 pathogenic Pathway analysis Patient Replication Research response RNA role SARS-CoV-2 SARS-COV-2 infection spread of COVID-19 suppressed tissue TNF Transcriptome upregulated upstream viral infection Viral protein with COVID-19 [DOI] 10.3390/genes11070760 PMC 바로가기 [Article Type] Article