SARS-CoV-2 in animals: potential for unknown reservoir hosts and public health implications동물의 SARS-CoV-2: 알려지지 않은 저수지 숙주의 가능성 및 공중 보건 영향Review Published on 2021-05-142022-09-10 Journal: The Veterinary Quarterly [Category] SARS, 변종, [키워드] 2019-nCoV acute respiratory syndrome acute respiratory syndrome coronavirus animal animals bats cats China Contact coronavirus COVID-19 cynomolgus macaques determine Evidence evidence of facilitated ferret ferrets globe hamster Host host range Human human-to-human transmission implication initial instances mammalian mink natural infection populations public health raccoon dogs reported reservoirs respiratory Result rhesus macaques SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 transmission SARS-CoV-2 variant severe acute respiratory syndrome coronavirus 2 susceptibility susceptible Transmission transmission of SARS-CoV-2 transmitted Viral white-tailed deer wild animal wildlife reservoir zoos [DOI] 10.1080/01652176.2021.1921311 PMC 바로가기 [Article Type] Review
Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genomeResearch Article Published on 2021-05-132022-10-28 Journal: Science (New York, N.y.) [Category] COVID-19, Fulltext, SARS, [키워드] antiviral intervention Compound coronavirus Cryo-electron microscopy downstream Efficiency experiment feature form generate inhibit SARS-CoV-2 Interaction mammalian mRNA observation polyprotein promote Proteins reduce Regulatory Replication RNA genome RNA-dependent RNA polymerase shown tension the SARS-CoV-2 translation Viral RNA [DOI] 10.1126/science.abf3546 PMC 바로가기 [Article Type] Research Article
Zebrafish as a Translational Model: An Experimental Alternative to Study the Mechanisms Involved in Anosmia and Possible Neurodegenerative Aspects of COVID-19?번역 모델로서의 Zebrafish: 후각 상실과 COVID-19의 가능한 신경퇴행성 측면과 관련된 메커니즘을 연구하기 위한 실험적 대안?Review Published on 2021-05-052022-09-10 Journal: eNeuro [Category] MERS, SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome coronavirus Anosmia aspect Asymptomatic Brain classical Clinical symptoms Cohort cohort of patients conditions coronavirus coronavirus disease coronavirus disease-2019 COVID-19 Danio Effect embryonic embryonic development Encephalitis feature functions Genetic genetic manipulation high availability induce investigated Logistic long-lasting mammalian mechanism neurodegeneration neurologic neurologic disorders neuroscience olfactory Olfactory system organism pandemic pathway Preclinical replications respiratory respiratory manifestations SARS-CoV-2 severe acute respiratory syndrome Coronavirus similarity suggested Symptom Treatment Variability Visual with COVID-19 zebrafish [DOI] 10.1523/ENEURO.0027-21.2021 PMC 바로가기 [Article Type] Review
The Course of SARS-CoV-2 in a Patient After a Recent Kidney Transplant: A Literature Review on COVID-19 Therapy최근 신장 이식 후 환자의 SARS-CoV-2 경과: COVID-19 치료에 대한 문헌 검토Review Published on 2021-05-012022-09-11 Journal: Transplantation proceedings [Category] SARS, 진단, 치료제, [키워드] abstracts Acute kidney injury acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach article calcineurin China Complete coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 therapy data extraction death died drug effective therapy effort European followed by following France group high risk inhibitor Intensive Italy Kidney injury kidney transplant kidney transplant recipients literature mammalian monoclonal antibody Mortality mortality rates Most patients mycophenolate mycophenolate mofetil Organ transplant outbreak outcome pandemic Part Patient patients populations PROTECT Rapamycin recent recipient reduce Replication researcher resource respiratory review SARS-CoV-2 screened severe acute respiratory syndrome Coronavirus severe complication severe complications solid organ solid organ transplant Spain steroid Steroids the disease The United States therapy Transplant Treatment United Kingdom United States Vaccine Withdrawal [DOI] 10.1016/j.transproceed.2021.03.008 PMC 바로가기 [Article Type] Review
Coronavirus Disease 2019 in Kidney Transplant Recipients: Single-Center Experience and Case-Control Study신장 이식 수혜자의 코로나바이러스 질병 2019: 단일 센터 경험 및 사례 통제 연구Article Published on 2021-05-012022-09-11 Journal: Transplantation proceedings [Category] SARS, 치료제, [키워드] age and sex Bacterial infections calcineurin Case fatality rate Case series Clinical course Clinical outcome clinical outcomes comparable Control controls coronavirus disease Coronavirus disease 2019 COVID-19 diagnosed with COVID-19 died drug level exclusion experience fatality Hemodialysis Hospitalized Immunosuppression Infection inhibitor kidney transplant recipients mammalian morbidity morbidity and mortality mTOR no significant difference no significant differences non-transplant patient non-transplant patients outcome pandemic Rapamycin recipient Secondary infection secondary infections single-center Sirolimus tacrolimus Transplant with COVID-19 [DOI] 10.1016/j.transproceed.2021.01.002 PMC 바로가기 [Article Type] Article
A novel one-step quick assay for detection of SARS-COV2 antibodies across mammalian speciesBiotechnology Published on 2021-04-272022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] acute respiratory syndrome aggregation antibodies antibody Bank can be used caused Community coronavirus Culture death detect Diego Escherichia coli Fluorescence human infection human serum immunoassay lateral flow immunoassay LFIA mammalian negative controls nucleocapsid protein Patient patients positive Protein rapid antibody test SARS-CoV2 secondary antibody sensitivity serological test serum sample serum samples specificity universal test virus virus infection were used [DOI] 10.7717/peerj.11381 PMC 바로가기 [Article Type] Biotechnology
Single-Cell RNA-seq Reveals Angiotensin-Converting Enzyme 2 and Transmembrane Serine Protease 2 Expression in TROP2 + Liver Progenitor Cells: Implications in Coronavirus Disease 2019-Associated Liver DysfunctionMedicine Published on 2021-04-222022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome analyzed angiotensin-converting enzyme 2 binding caused cell death cell population China cirrhotic liver co-expression Comorbidities coronavirus coronavirus disease COVID-19 COVID-19 patient Cytokine storms Deleterious develop disease fetal FIVE globe healthy host cell human liver impair implicated indicated liver Liver cirrhosis liver dysfunction liver tissue mammalian mammalian cell pandemic pathophysiology Patient prevalent progenitor Protein receptor reported respiratory symptom Respiratory virus infection RNA-Seq SARS-CoV-2 scRNA-seq serine protease significantly Single Cell single-cell RNA-seq spike the S protein tissue TMPRSS2 transmembrane serine protease Trop2 viral infection [DOI] 10.3389/fmed.2021.603374 PMC 바로가기 [Article Type] Medicine
Role of Structural and Non-Structural Proteins and Therapeutic Targets of SARS-CoV-2 for COVID-19COVID-19에 대한 SARS-CoV-2의 구조적 및 비구조적 단백질과 치료 표적의 역할Review Published on 2021-04-062022-09-11 Journal: Cells [Category] MERS, SARS, 신약개발, 진단, 치료법, [키워드] 2019-nCoV accessory protein accessory proteins ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Amino acid angiotensin angiotensin converting enzyme 2 Angiotensin-converting enzyme angiotensin-converting enzyme 2 bats cats causative agent cellular entry cleavage components consequence convalescent plasm Coronaviridae coronavirus coronavirus disease Coronavirus disease-19 Coronavirus-2 COVID-19 death downstream drugs encapsulate event family focus functional Genome genomic genomic RNA greater gRNA host cell host cell receptor hosts humans Infection lead mammalian MERS MERS-CoV molecular molecular function molecular target myriad non-structural protein Novel coronavirus polymerase polyproteins positive-sense pp1a pp1ab protease proteolytic cleavage RBD Receptor binding domain referred to replicase respiratory resulting RNA genome role S protein SARS-CoV SARS-CoV-2 SARS-COV-2 infection sequence identity Serine serine 2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus sgRNAs similarity single-stranded Spike protein spike protein of SARS-CoV-2 Spread ssRNA structural protein structural proteins subgenomic mRNA subgenomic mRNAs synthesis target therapeutic therapy TMPRSS2 translated translation transmembrane transmembrane protease serine 2 undergo Vaccine Variability Viral Viral RNA virus [DOI] 10.3390/cells10040821 PMC 바로가기 [Article Type] Review
A systematic review of experimental evidence for antiviral effects of ivermectin and an in silico analysis of ivermectin’s possible mode of action against SARS-CoV-2이버멕틴의 항바이러스 효과에 대한 실험적 증거의 체계적인 검토 및 SARS-CoV-2에 대한 이버멕틴의 가능한 작용 방식에 대한 실리코 분석Review Published on 2021-04-012022-09-11 Journal: Fundamental & clinical pharmacology [Category] SARS, 신약개발, 치료제, [키워드] 95% confidence interval Antiviral antiviral agent Antiviral effect applicability applied Circoviridae Clinical efficacy Control Coronaviridae Coronaviridae family determine Developing dose economic loss Efficacy Evidence experimental evidence facilitated Flaviviridae Host in silico analysis in vitro In vitro studies in vitro study in vivo infected cell infected cells Infection infections inhibited Ivermectin mammalian mechanism meta-analyses Meta-analysis mice multiple organs nuclear nuclear location signals. nuclear translocation pharmacokinetic Propagation Replication SARS-CoV-2 SARS-CoV-2 genome selective shown standardized mean difference systematic review therapeutic agents toxic Toxicity Trial unmet need viral infection viral infections Viral proteins viral replication virus while [DOI] 10.1111/fcp.12644 PMC 바로가기 [Article Type] Review
Amino acid sensing pathway: A major check point in the pathogenesis of obesity and COVID-19아미노산 감지 경로: 비만과 코로나19 발병의 주요 체크포인트Review Published on 2021-04-012022-09-11 Journal: Obesity Reviews [Category] SARS, 유전자 메커니즘, [키워드] Activation aggravate Amino acid amino acid sensor GCN2 amino acids antiviral response Comorbidities Comorbidity correlation COVID-19 COVID-19 susceptibility deficiency effective GCN2 Host host cell host cells Hyperactivation IL-1β increase Infection Inflammation inhibiting interleukin interleukin-1 beta intestinal inflammation mammalian mechanism mitigate Mortality mTOR obesity obesogenic opposite overnutrition oxygen Pathogenesis Pathologies pathway pro-inflammatory cytokine Rapamycin reactive oxygen species reactive oxygen specy Replication reprogramming ROS SARS-CoV-2 serum shown suppresse susceptibility translation translational viral infections Viremia while with COVID-19 [DOI] 10.1111/obr.13221 PMC 바로가기 [Article Type] Review