mendelian randomization – Page 9 – Communicable Diseases Research

Leveraging Genetic Data to Elucidate the Relationship Between COVID‐19 and Ischemic Stroke

유전 데이터를 활용하여 COVID-19와 허혈성 뇌졸중 사이의 관계 설명

Original Research

Published on 2021-11-102022-09-10
Journal: Journal of the American Heart Association [Category] MERS, 변종,

Smoking is significantly associated with increased risk of COVID-19 and other respiratory infections

Article

Published on 2021-10-282022-10-04
Journal: Communications Biology [Category] MERS, 유전자 메커니즘,

[키워드] 95% CI Addiction alcohol Analysis association Bacterial cardiometabolic diseases Cardiometabolic risk factors Coronavirus 2019 COVID-19 COVID-19 infection COVID-19 pandemic COVID-2019 demonstrated epidemiological European evaluate Evidence Genetic Hospitalization increase increased risk infection risk Influenza virus mendelian randomization multivariable observational study Odds ratio other respiratory infection other respiratory infections Participants performed Pneumonia public health reducing remained Respiratory disease respiratory infections risk Risk factors robust significantly smoking Substance use Substance use disorder with COVID-19
[DOI] 10.1038/s42003-021-02685-y PMC 바로가기 [Article Type] Article

Education Attainment, Intelligence and COVID-19: A Mendelian Randomization Study

Article

Published on 2021-10-222022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

Genetic Predisposition Between COVID-19 and Four Mental Illnesses: A Bidirectional, Two-Sample Mendelian Randomization Study

Psychiatry

Published on 2021-10-202022-10-31
Journal: Frontiers in Psychiatry [Category] COVID-19,

[키워드] 2019 coronavirus disease 95% CI 95% confidence interval addition analyses Analysis approach association Characteristics complementary conducted contribute COVID-19 COVID-19 infection datasets Depression disorder Evidence Genetic Genome-wide association study global pandemic GWAS higher risk horizontal pleiotropy Hospitalization illnesses increased risk increased the risk indicated individual inverse-variance weighted mendelian randomization Mental mental illness MR sensitivity analysis MR-Egger multiple sensitivity analysis neurological offer outbreak outcome outlier Population predicted preventative measure random-effect reported risk Schizophrenia severity of COVID-19 significantly Support was obtained weighted median
[DOI] 10.3389/fpsyt.2021.746276 PMC 바로가기 [Article Type] Psychiatry

A Chinese host genetic study discovered IFNs and causality of laboratory traits on COVID-19 severity

Research article

Published on 2021-10-012022-10-05
Journal: iScience [Category] 변종, 유전자 메커니즘,

Herpesvirus infections and Alzheimer’s disease: a Mendelian randomization study

Research

Published on 2021-09-242024-09-02
Journal: Alzheimers Res Ther [Category] 대상포진,

[키워드] Alzheimer’s disease herpesvirus Infection mendelian randomization
[DOI] 10.1186/s13195-021-00905-5 PMC 바로가기 [Article Type] Research

Unraveling Risk Genes of COVID-19 by Multi-Omics Integrative Analyses

Medicine

Published on 2021-09-072022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevance

프로테옴 전반에 걸친 유전자 조사는 임상 관련성이 있는 여러 SARS-CoV-2 악용 숙주 표적을 식별합니다.

Research Article

Published on 2021-08-172022-09-10
Journal: eLife [Category] MERS, SARS, 유전자 메커니즘,

[키워드] ABO Accepted Affect affecting age Alpha Analysis Antiviral Apoptosis applied approach arising association Author cause CD209 clinical trial contribute COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patient COVID-19 phenotypes datasets DC-SIGN death Demographic factors demonstrated disease severity evade explain Factor Factors funding Gender gene expression level gene mutation Genetic genetic colocalization genetic profile healthy individuals help Host host cells host protein host proteins Human identify identifying IL-6R immune immune response individual individuals infect Infection interact Interaction involved Karim MAK mechanism Medical Research Council mendelian randomization minor symptom minor symptoms molecular mutate natural experiment new strain no symptom no symptoms OAS1 open Open Access opens Patient patients with COVID-19 pleiotropic Potential treatment precursor predict predicted Probability PROTECT Protein Proteins proteome provide randomisation reaction receptor receptor protein reduce Research response responsible risk SARS-CoV-2 severe COVID-19 severity of COVID-19 SIGN Spike protein Strains submission susceptibility susceptible susceptible hosts Symptoms target targets the spike protein the strongest Therapeutics treat Treatment Trigger unique unit variety virus virus strains viruses Wellcome Trust with COVID-19
[DOI] 10.7554/eLife.69719 PMC 바로가기 [Article Type] Research Article

The genetic architecture of plasma kynurenine includes cardiometabolic disease mechanisms associated with the SH2B3 gene

Article

Published on 2021-08-022022-10-04
Journal: Scientific Reports [Category] 바이오마커,

[키워드] approach association Biomarker C-reactive protein cardiometabolic disease cardiovascular diseases chronic inflammation clinical phenotype conducted contributing to CRP diagnose Disease genetics examined FDR Gene regulation Genetic genetic architecture humans identify include increase increased risk independent Inflammation Inflammatory inflammatory pathway involved marker mechanism mendelian randomization metabolism metabolite mice missense variant obesity Pathways plasma Plasma level polymorphism Prognostic markers Record regulate Regulation risk Sh2b3 single-nucleotide SNP SNPs SNPs mapping upstream Variability variant
[DOI] 10.1038/s41598-021-95154-9 PMC 바로가기 [Article Type] Article

Using genetic variants to evaluate the causal effect of serum vitamin D concentration on COVID-19 susceptibility, severity and hospitalization traits: a Mendelian randomization study

유전적 변이를 사용하여 COVID-19 감수성, 중증도 및 입원 특성에 대한 혈청 비타민 D 농도의 인과적 영향 평가: Mendelian randomization study

Research

Published on 2021-07-102022-09-10
Journal: Journal of Translational Medicine [Category] SARS, 변종,

[키워드] 25-hydroxyvitamin D 95% CI 95% confidence interval Analysis applied association Bonferroni-corrected Concentration coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 susceptibility Effect evaluate Evidence fixed Genetic variant GWAS horizontal pleiotropy Hospitalization Hospitalized humans IVW mendelian randomization MR-Egger MR-PRESSO nucleotide Odds ratio outlier pandemic performed PhenoScanner tool pleiotropic profile provided random effect Randomized controlled trial Result risk of COVID-19 score Sensitivity analyses serum serum vitamin D severity Single nucleotide polymorphism single nucleotide polymorphisms SNPs supplementary material Support susceptibility threshold traits Treatment treatment of COVID-19 Vitamin D Vitamin D supplementation widespread with COVID-19
[DOI] 10.1186/s12967-021-02973-5 PMC 바로가기 [Article Type] Research