metabolites – Page 9 – Communicable Diseases Research

“Waste Not, Want Not” — Leveraging Sewer Systems and Wastewater-Based Epidemiology for Drug Use Trends and Pharmaceutical Monitoring

Preliminary Research

Published on 2021-08-162022-10-30
Journal: Journal of Medical Toxicology [Category] Coronavirus, MERS, SARS,

Comparison of metabolites and variety authentication of Amomum tsao-ko and Amomum paratsao-ko using GC–MS and NIR spectroscopy

Article

Published on 2021-07-262022-10-04
Journal: Scientific Reports [Category] 바이오마커,

Proteomics and metabonomics analyses of Covid-19 complications in patients with pulmonary fibrosis

폐 섬유증 환자의 COVID-19 합병증의 단백질 학 및 대사제 분석

Article

Published on 2021-07-162022-09-10
Journal: Scientific Reports [Category] 바이오마커, 유전자 메커니즘, 치료기술, 치료제,

[키워드] acquisition Analysis analyzed association Cell Biology Clustering collected Complication differential expression disease enrichment analysis Evidence FcγR feature fibrosis FIVE independent inflammatory pathways lesion lesions lobes lower lobe lower lobes Mechanisms of disease medical record medical records metabolites metabolomics Molecular medicine Pathogenesis pathway Pathways Patient phagocytosis PPAR signaling progression Protein proteomics pulmonary pulmonary fibrosis quantification serum biomarker serum biomarkers signaling pathway signaling pathways targeted therapy urea urea cycle were used
[DOI] 10.1038/s41598-021-94256-8 PMC 바로가기 [Article Type] Article

Prolonged SARS-CoV-2 RNA virus shedding and lymphopenia are hallmarks of COVID-19 in cancer patients with poor prognosis

장기간 SARS-CoV-2 RNA 바이러스 배출 및 림프구감소증은 예후가 불량한 암 환자에서 COVID-19의 특징입니다

Article

Published on 2021-07-062022-09-10
Journal: Cell Death and Differentiation [Category] SARS, 유전자 메커니즘, 임상, 치료기술,

[키워드] accompanied activated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 anti-RBD IgG antibodies association Blood Cancer cancer patient Cancer patients Cancer therapy carriers CD8 cells circulation coronavirus Coronavirus-2 correlated COVID-19 COVID-19 severity cycle threshold death Depletion DNA early phase Elevation Enterobacteriaceae Eomes exacerbate exhibited family members favor follicular granzyme granzyme B Gut hallmark higher risk IFN immature immunopathology Infection Infectious disease lymphocyte Lymphocyte count lymphopenia magnitude malignant disease mechanism Medical research metabolite metabolites Monocytes Nasopharyngeal swab nasopharyngeal swabs Neutrophils pandemic paradoxical pathway Patient PD-1 plasmablasts polyamine poor prognosis Prognostic markers Prolonged RBD IgG reduce respiratory RT-qPCR salt SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 RNA detection serum severe COVID-19 significant changes in T-helper cells Viral Viral RNA Viral RNA shedding virus virus–host interaction virus–host interactions worsened
[DOI] 10.1038/s41418-021-00817-9 PMC 바로가기 [Article Type] Article

Kynurenic acid may underlie sex-specific immune responses to COVID-19

Research Resource

Published on 2021-07-062022-10-28
Journal: Science Signaling [Category] COVID-19, SARS,

[키워드] Activation age Analysis chemokine Clinical outcome clinically Coronavirus disease 2019 correlated COVID-19 COVID-19 patient COVID-19 patients cytokine abundance disease enzyme examined expression female females gene encoding Glutamate Health care worker immune response immune responses individuals Inflammation Inflammatory cytokine inhibit Kynurenic acid male Male sex males metabolism metabolite metabolites metabolome metabolomics Mortality Older outcome Patient patients performed positive positively correlated regulated reveal risk factor SARS-COV-2 infection serum T cell responses the disease underlie uninfected was reduced
[DOI] 10.1126/scisignal.abf8483 PMC 바로가기 [Article Type] Research Resource

Multi-omic profiling of plasma reveals molecular alterations in children with COVID-19

혈장의 다중 생물 프로파일 링

Research Paper

Published on 2021-07-062022-09-10
Journal: Theranostics [Category] MERS, SARS, 유전자 메커니즘,

[키워드] Adults alteration Analysis Anti-inflammatory antioxidant AUC blood sample Blood samples children children with COVID-19 Cohort Combination conducted Coronaviral coronavirus disease Coronavirus disease 2019 Coronavirus infection COVID-19 demonstrated develop enrolled exhibiting experiment expression finding healthy children Hospital admission Hospital admissions identify immune Inference inhibited less machine learning mannitol mechanism metabolite metabolites metabolomic profiling methylmalonic acid Mild symptom mild symptoms molecular molecules outpatients Pathogenesis pathogenesis of COVID-19 performed plasma potential therapeutic agent potential therapeutic agents pro-inflammatory factors Protective protective effect Protective effects protective role Protein proteomic provided Replication reveal severe symptom statistical analyses suppressed therapeutic agents up-regulated
[DOI] 10.7150/thno.61832 PMC 바로가기 [Article Type] Research Paper

Antiviral effects of probiotic metabolites on COVID-19

COVID-19에 대한 프로바이오틱 대사물의 항바이러스 효과

Article

Published on 2021-07-012022-09-11
Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료제,

Combined Metabolic Activators Accelerates Recovery in Mild‐to‐Moderate COVID‐19

결합 된 대사 활성화 제는 온화한 중등도의 CovID -19에서 회복을 가속화합니다

Clinical Trial

Published on 2021-06-282022-08-13
Journal: Advanced Science [Category] MERS, 임상,

[키워드] accelerate activator adenine administration ambulatory patient ambulatory patients Amino acid antioxidant antioxidant metabolism changes Clinical data clinical trial CMAs Combined combined metabolic activator combined metabolic activators complete recovery comprehensive analysis conducted COVID‐19 COVID‐19 patients deficiencies deficiency double‐blinded phase effective glutathione glutathione metabolism immune response IMPROVE include Infection Inflammation inflammatory proteomics investigated l ‐carnitine l ‐carnitine tartrate lead lipid metabolism metabolic metabolic abnormalities metabolic function metabolism metabolite metabolites metabolomics mitochondrial mitochondrial dysfunction mixture NAD+ nicotinamide nicotinamide adenine dinucleotide nicotinamide riboside omics data Open‐label phase Patient patients treated Phase 2 phase 3 trial Phase 3 trials phase‐2 phase‐3 Placebo placebo group Placebo‐controlled Plasma level Plasma levels plasma metabolome plasma metabolomics precursor Protein proteome proteomics regulate respiratory respiratory problems reveal Safe salt shown significantly significantly shorter therapeutic regime therapeutic strategy Treatment
[DOI] 10.1002/advs.202101222 PMC 바로가기 [Article Type] Clinical Trial

Recent Progress in Metabolic Syndrome Research and Therapeutics

Review

Published on 2021-06-252022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS,

[키워드] acute respiratory syndrome affected approach cellular Characteristics Comprehensive consequence contributed coronavirus differentially expressed disease entity dysregulation energy metabolism facilitate gut microbiota heterogeneity homeostasis Host Impact incidence Infection inflammatory status inquiry mandatory measure mechanism metabolic metabolic parameters metabolic syndrome metabolites metabolomics microbiota molecular pathogenic mechanisms phenotype physical activity Population Precision precision medicine Progress Protein proteomics recent risk SARS-CoV-2 signaling pathway therapeutic Therapeutics Therapies Variation
[DOI] 10.3390/ijms22136862 PMC 바로가기 [Article Type] Review

Targeting 3CLpro and SARS-CoV-2 RdRp by Amphimedon sp. Metabolites: A Computational Study

Article

Published on 2021-06-212022-10-30
Journal: Molecules [Category] COVID-19, SARS,