Chimeric camel/human heavy-chain antibodies protect against MERS-CoV infection키메라 낙타/인간 중쇄 항체는 MERS-CoV 감염으로부터 보호합니다Research Article Published on 2018-08-082022-09-14 Journal: Science Advances [Category] 비임상, 진단, [키워드] Affinity maturation antibodies antibody Antibody Response binding blocked Bone marrow caused chimeric complementarity-determining region concentrations develop domain Dromedary epitope event expression heavy chain high affinity Human humans Intervention MERS coronavirus MERS-CoV MERS-CoV infection mice Middle East mild infection nanobodies outbreak Pathogens PROTECT Receptor binding domain recognize repeated respiratory syndrome coronavirus responses selected serum unique viral spike protein virus virus entry virus-neutralizing antibody [DOI] 10.1126/sciadv.aas9667 PMC 바로가기 [Article Type] Research Article
The dominance of human coronavirus OC43 and NL63 infections in infantsArticle Published on 2011-12-192022-11-01 Journal: Journal of Clinical Virology [Category] Coronavirus, MERS, [키워드] 229E addition childhood children determine disease elicit Epidemiology explain Frequency HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 healthy children HKU1 hospital Hospitalized human coronavirus human coronavirus OC43 Immunity indication Infant infect infecting Infection infections less majority mild infection natural infection Newborn NL63 objective OC43 occur pathogenic positive PROTECT real time respiratory infection respiratory tract Result RT-PCR sequence Seroconversion seroconverted serology severe disease study group subsequent was determined [DOI] 10.1016/j.jcv.2011.11.011 PMC 바로가기 [Article Type] Article
The SARS-Unique Domain (SUD) of SARS Coronavirus Contains Two Macrodomains That Bind G-QuadruplexesResearch Article Published on 2009-05-152022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] 2003 acute respiratory syndrome ADP-ribose amino-acid Apoptosis Author bats bind binding coding compared component concerning coronavirus crystal structure determine determined different domain Evidence extreme form found function functional G-quadruplex gel electrophoresis Genome genomic RNA help homodimer host cell humans immune response in vitro include Infected involved lysine macrodomain mild infection monomer mRNA Mutation non-structural protein nucleic acid nucleotides nucleus occur oligonucleotide other coronaviruses outbreak pathogenicity Possible Protein protein 3 reduction Region regulate related virus remained Replication residue residues responsible RNA SARS Coronavirus SARS-CoV selected Seven shown Signal transduction Structure structures target three-dimensional structure Transcription viral infection viral replication virus X-ray crystallography [DOI] 10.1371/journal.ppat.1000428 PMC 바로가기 [Article Type] Research Article
Severe Acute Respiratory Syndrome–associated Coronavirus InfectionDispatch Published on 2003-11-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] Adult antibody Asymptomatic coronavirus Course examined Health care worker healthcare worker hospital illnesses Infection Mild mild infection occurred outbreak Prevalence respiratory SARS SARS CoV SARS-CoV severe Severe acute respiratory syndrome [DOI] 10.3201/eid0911.030421 PMC 바로가기 [Article Type] Dispatch