Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants
Research Article
[키워드] Antiviral
Antiviral agents
antiviral drug
antiviral strategy
applied
approach
binding
blocked
catalytic
catalytic activity
cellular
cleaving
complicate
component
Critical
develop
domain
DUB
Ebola
effective
enzyme
Enzymes
expression
Health
Hemorrhagic fever virus
high affinity
Host
humans
identify
infect
infected patient
Infection prevention
inhibit
inhibited
inhibitor
inhibitors
innate immune responses
interferon
ISG15
magnitude
MERS-CoV
MERS-CoV infection
Middle East
molecular interaction
mRNA
outbreak
Outbreaks
Papain-like protease
pathogenic virus
pathogenicity
plants
polyprotein
potent
progeny
PROTECT
Protein
Protein design
provide
reduced
Replication
replicative
respiratory syndrome coronavirus
responsible
selective
similarity
specificity
stimulated
suppress
targets
therapeutic
therapy
transgenic
Treatment
variant
variety
viral pathogen
viral replicase polyprotein
viral replication
virus
viruses
while
Zika virus
[DOI] 10.1371/journal.ppat.1006372 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1006372 PMC 바로가기 [Article Type] Research Article