Characterizing SARS-CoV-2 Viral Clearance Kinetics to Improve the Design of Antiviral Pharmacometric StudiesSARS-CoV-2 바이러스 제거 동역학 특성화를 통해 항바이러스 약리학적 연구 설계 개선Article Published on 2022-07-192022-09-11 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID19(2023년), SARS, 임상, 치료기술, 치료제, [키워드] analyzed Antiviral antiviral drug antiviral drugs antiviral effects antiviral treatments assessment clearance clearance rate clinical trials conducted Consensus COVID-19 illness Effect estimate exponential decay model individuals Infection Kinetics methodology Metrics molnupiravir Nasopharyngeal swab Nasopharyngeal swab samples Nirmatrelvir Patient Pharmacodynamics Phase 2 profile provide qPCR randomized trial randomized trials reduced reported robust Sample size sample sizes SARS-CoV-2 splines Statistical power time to clearance. Trial viral clearance Viral load virological response [DOI] 10.1128/aac.00192-22 PMC 바로가기 [Article Type] Article
Molnupiravir inhibits SARS-CoV-2 variants including Omicron in the hamster modelMolnupiravir는 햄스터 모델에서 Omicron을 포함한 SARS-CoV-2 변이체를 억제합니다Article Published on 2022-07-082022-09-11 Journal: JCI Insight [Category] COVID19(2023년), SARS, 변종, [키워드] Administered Adults Alpha Analysis Antiviral approved Beta caused COVID-19 Delta VOC delta VoCs demonstrated drug drug therapy effective Efficacy examined hamster hamsters Histopathologic analysis identify infectious titer infectious titers inhibit inhibited inhibitory effect Lower respiratory tract lung Lung disease Lungs Measures mechanism molnupiravir mouse Mouse models mutagenic mutated nucleoside omicron Preexisting immunity reduction in Replication SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 lineage SARS-CoV-2 variant SARS-CoV-2 variants Spike protein the SARS-CoV-2 Treatment upper and lower respiratory tract variant Viral antigen viral RNA genome Virology virus replication VoC VOCs was reduced [DOI] 10.1172/jci.insight.160108 PMC 바로가기 [Article Type] Article
Paxlovid: Mechanism of Action, Synthesis, and In Silico StudyPaxlovid: 작용 메커니즘, 종합 및 인 실리코 연구Review Published on 2022-07-072022-09-11 Journal: BioMed Research International [Category] COVID19(2023년), SARS, 치료제, [키워드] Action antiviral activity antiviral drug antiviral efficacy antivirus antiviruses Biochemistry candidate cleave clinical trial Combination coronavirus COVID COVID-19 COVID-19 pandemic described description drug flexible Glutamine human coronavirus Immune profile in vitro in vivo inhibiting inhibitor mechanism mechanism of action molnupiravir Nirmatrelvir Organic chemistry pandemic Paxlovid PF-07321332 Pfizer Pharmacology polyprotein protease Protease inhibitor Proteases replaced REPLACED BY reported Ritonavir SARS-CoV-2 protease synthesis Treatment treatment of COVID-19 Vaccine viral replication [DOI] 10.1155/2022/7341493 PMC 바로가기 [Article Type] Review
Recapitulating infection, thermal sensitivity and antiviral treatment of seasonal coronaviruses in human airway organoids인간 기도 오르가노이드에서 계절성 코로나바이러스의 감염, 열 민감도 및 항바이러스 치료 요약Article Published on 2022-07-012022-09-11 Journal: EBioMedicine [Category] 치료제, [키워드] 229E Airway organoids Analysis antiviral activity antiviral therapy Antiviral treatment approved conditions Coronavirus infection Coronavirus infections COVID COVID19 development experimental model facilitate favor funding help host response Human human airway Infection infections Infectious virus inhibited interactions Kinetics medication medications Mild molnupiravir Netherland NL63 OC43 occur organization Organoid Pathogenesis phenotype populations Remdesivir replicate Replication Research research and development resulting RNA sequencing robust seasonal seasonal coronavirus seasonal coronaviruses severe complication severe complications Society Support supported temperature tested therapeutic thermal Thermal sensitivity Transcriptome transcriptomic Transmissibility upper respiratory tract viral replication virus replication Virus-host interaction Virus-host interactions was performed was tested [DOI] 10.1016/j.ebiom.2022.104132 PMC 바로가기 [Article Type] Article
Cost-Effectiveness Analysis of Molnupiravir Versus Best Supportive Care for the Treatment of Outpatient COVID-19 in Adults in the US미국 성인의 코로나19 외래환자 치료를 위한 몰누피라비르 대 최상의 지지 요법의 비용 효율성 분석Article Published on 2022-07-012022-09-11 Journal: PharmacoEconomics [Category] MERS, 바이오마커, 변종, [키워드] acute phase adult outpatient adult outpatients Adult patients affected Analysis Antiviral best Care changes changes in conducted coronavirus disease Coronavirus disease 2019 Cost effectiveness COVID-19 COVID-19 outpatients database de novo Decision tree decrease died dominant effective Electronic health record Electronic health records evaluated healthcare Healthcare system highest Hospitalization Hospitalized Immunity increase in information Intervention less Markov medical costs Mild-to-moderate molnupiravir outcome Outpatient pandemic parameter Patient patient population Perspective Primary outcomes Probability progression proportion real-world data reduction remained reported Research risk sensitivity analysis severe disease Society supportive care Therapies threshold transition transition probabilities treated treating COVID-19 Treatment Trial unavailability utility vaccination Viral Viral variants with COVID-19 [DOI] 10.1007/s40273-022-01168-0 PMC 바로가기 [Article Type] Article
Ethical concern regarding the UK PANORAMIC COVID-19 trialUK PANORAMIC COVID-19 시험에 대한 윤리적 우려Article Published on 2022-07-012022-09-11 Journal: British Journal of Clinical Pharmacology [Category] 임상, [키워드] Abstract COVID-19 Declaration of Helsinki Helsinki Informed consent molnupiravir PANORAMIC trial Trial unvaccinated individuals vaccinated individuals [DOI] 10.1111/bcp.15275 PMC 바로가기 [Article Type] Article
Synergism of interferon-beta with antiviral drugs against SARS-CoV-2 variantsCorrespondence Published on 2022-07-012022-10-05 Journal: The Journal of Infection [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] antiviral drug antiviral therapy Aprotinin combination therapy COVID-19 interferon Interferon-beta molnupiravir Nirmatrelvir Remdesivir SARS-CoV-2 SARS-CoV-2 variant [DOI] 10.1016/j.jinf.2022.07.023 [Article Type] Correspondence
Highly sensitive high-performance thin-layer chromatography method for the simultaneous determination of molnupiravir, favipiravir, and ritonavir in pure forms and pharmaceutical formulationsArticle Published on 2022-07-012023-07-09 Journal: Journal of separation science [Category] COVID19(2023년), [키워드] COVID-19 Favipiravir high-performance thin-layer chromatography molnupiravir Ritonavir [DOI] 10.1002/jssc.202200178
Molnupiravir for the treatment of COVID-19Article Published on 2022-07-012023-07-10 Journal: Drugs of today (Barcelona, Spain : 1998) [Category] COVID19(2023년), [키워드] Anti-SARS-CoV-2 Agents antiviral drugs COVID-19 molnupiravir Nucleoside analogues RNA-dependent RNA polymerase (RdRp) inhibitors Viral replication inhibitors. [DOI] 10.1358/dot.2022.58.7.3419558
A novel property of hexokinase inhibition by Favipiravir and proposed advantages over Molnupiravir and 2 Deoxy D glucose in treating COVID-19Favipiravir에 의한 헥소키나아제 억제의 새로운 특성 및 COVID-19 치료에서 Molnupiravir 및 2 Deoxy D 포도당보다 제안된 이점Article Published on 2022-07-012022-09-11 Journal: Biotechnology letters [Category] COVID19(2023년), SARS, 치료제, [키워드] 2 Deoxy D glucose activity affected antiviral drug Concentration COVID-19 Cyan Ebola exhibited Favipiravir flu Glucose Health Hexokinase Host inhibiting Inhibition assays molecular docking molecular docking studies molnupiravir Remdesivir SARS-CoV-2 shown Spread supported treat treating COVID-19 treatment regimen Trial trials wake [DOI] 10.1007/s10529-022-03259-6 PMC 바로가기 [Article Type] Article